Treatment of Periodontitis by Local Administration of Minocycline Microspheres: A Controlled Trial

Williams, Ray C.; Paquette, David W.; Offenbacher, Steven; Adams, Donald F.; Armitage, G. C.; Bray, Kimberly Krust; Caton, Jack G.; Cochran, David L.; Drisko, Connie Hastings; Fiorellini, Joseph P.; Giannobile, William V.; Grossi, Sara G.; Guerrero, D. M.; Johnson, Georgia K.; Lamster, Ira B.; Magnusson, Ingvar; Oringer, Richard J.; Persson, G. Rutger; Dyke, Thomas E. Van; Wolff, Larry F.; Santucci, Edward A.; Rodda, Bruce E.; Lessem, Jan

doi:10.1902/jop.2001.72.11.1535

Cited by 198 publications

(214 citation statements)

References 42 publications

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“…However, research has focused on the development of a new treatment to appropriately deliver the drug into the periodontal pockets. For instance, a method of microencapsulating minocycline hydrochloride in a bioabsorbable polymer (polyglycolide-co-dl-lactide) has been developed, resulting in microspheres that are administered into sites with periodontal disease 22 . The aim of this study was to evaluate the presence of periodontal pathogens and the clinical response to SRP periodontal pocket treatment associated with subgingival minocycline (SM) in chronic periodontitis subjects.…”

Section: Introductionmentioning

confidence: 99%

Clinical and microbial evaluation of dental scaling associated with subgingival minocycline in chronic periodontitis subjects

et al. 2004

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ABSTRACT:The aims of this double-blind randomized clinical trial were to evaluate the presence of periodontal pathogens and the clinical response of periodontal pockets treatment to scaling and root planing (SRP) associated with subgingival minocycline (SM). A total of 36 subjects, 26 to 60 years old (40.7 ± 9.1), who had been previously diagnosed with chronic periodontitis, were included in the present study. Eighteen subjects were selected for the test group (TG), who were treated with SRP plus SM (new treatment), and 18 subjects for the control group (CG) who received SRP plus vehicle (current treatment). Two homologous sites in each subject with a probing depth (PD) ≥ 6 mm were chosen. To evaluate the clinical response after treatment, PD was measured at baseline and at 90 days. Microbiological evaluation was performed to detect 7 periodontal pathogens using polymerase chain reaction at baseline, 30, and 120 days. A mean reduction in PD of 2.8 and 2.1 mm was observed in the TG and CG, respectively. At baseline, P. gingivalis was the most prevalent organism in both test (65.8%) and control (48.6%) groups. After 120 days it fell to 30.8% in TG and to 23.1% in CG. There were no statistically significant differences between the test and control groups concerning PD (p > 0.05 by Wilcoxon test) or presence of periodontal pathogens (p > 0.05 by Wilcoxon and chi-square; p > 0.01 by Signal test). The results observed showed that the new treatment was as effective as the current treatment in reducing periodontal pathogens and PD among chronic periodontitis subjects. DESCRIPTORS: Bacteria; Dental scaling; Minocycline. RESUMO:O objetivo deste estudo randomizado duplo-cego foi avaliar a presença de periodontopatógenos e o comportamento clínico de bolsas periodontais tratadas com raspagem e aplainamento radicular (RAR) associado à minociclina subgengival (MS). Foram incluídos no presente estudo 36 indivíduos de 26 a 60 anos de idade (40,7 ± 9,1), previamente diagnosticados com periodontite crônica. Dezoito indivíduos foram selecionados para o grupo teste (GT), tratado com RAR e MS (novo tratamento), e 18 indivíduos, para o grupo controle (GC), que recebeu RAR e veículo (tratamento convencional). Foram selecionados dois sítios homólogos em cada indivíduo com profundidade de sondagem (PS) ≥ 6 mm para testar a hipótese proposta. Para avaliar o comportamento clí-nico após o tratamento, a mensuração da PS foi realizada inicialmente e após 90 dias. A avaliação microbiana foi realizada para detecção de 7 periodontopatógenos através de reação em cadeia da polimerase, inicialmente e após 30 e 120 dias. Observou-se redução média de 2,8 e 2,1 mm na PS nos grupos teste e controle, respectivamente. Inicialmente, P. gingivalis foi o microrganismo mais prevalente tanto no GT (65,8%) quanto no GC (48,6%). Após 120 dias, houve redução para 30,8% no GT e 23,1% no GC. Não houve diferenças estatisticamente significativas entre os grupos em relação à PS (teste Wilcoxon -p > 0,05) e presença dos periodontopatógenos (teste Wilcoxon e qui-quadra...

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Section: Introductionmentioning

confidence: 99%

Clinical and microbial evaluation of dental scaling associated with subgingival minocycline in chronic periodontitis subjects

et al. 2004

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“…Quiryen et al suggested that CHX treatment should be re-evaluated as an adjunct to SRP periodontal therapy (Quiryen et al, 2000). While the use of antibiotics (e.g., minocycline and tetracycline) represents a possible adjunct to SRP, and local drug delivery systems can improve clinical and microbial outcomes (Williams et al, 2001), their systemic use has undesirable side effects (e.g., antibiotic resistance, pseudomembranous colitis) (Radvar et al, 1996;Kinane and Radvar, 1999). The development of alternative treatments for periodontitis thus remains an important area of current oral health care research.…”

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confidence: 99%

Antibacterial Efficacy of Exogenous Nitric Oxide on Periodontal Pathogens

Backlund¹,

Sergesketter²,

Offenbacher

et al. 2014

J Dent Res

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Current treatments for periodontitis (e.g., scaling/ root planing and chlorhexidine) have limited efficacy since they fail to suppress microbial biofilms satisfactorily over time, and the use of adjunctive antimicrobials can promote the emergence of antibiotic-resistant organisms. Herein, we report the novel application of nitric oxide (NO)-releasing scaffolds (i.e., dendrimers and silica particles) as anti-periodontopathogenic agents. The effectiveness of macromolecular NO release was demonstrated by a 3-log reduction in periodontopathogenic Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis viability. In contrast, Streptococcus mutans and Streptococcus sanguinis, caries-associated organisms, were substantially less sensitive to NO treatment. Both dendrimerand silica-based NO release exhibited substantially less toxicity to human gingival fibroblasts at concentrations necessary to eradicate periodontopathogens than did clinical concentrations of chlorhexidine. These results suggest the potential utility of macromolecular NO-release scaffolds as a novel platform for the development of periodontal disease therapeutics.

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“…However, systemic 452 antibiotics should not be used in treatment of all forms of chronic periodontitis (13) , the development of resistance as well as drug interactions as a side effects are important reasons to limit the usage of systemic chemotherapeutic agents and to begin a new era in usage of topical sub-gingival delivery of therapeutic agents (14) .The main advantage of the topical delivery system therapy is to bring high concentrations and slowly sustained release of chemotherapeutic agents within the periodontal pocket without exposing the whole body to avoid their systemic side effects (15) . For example, the local delivery systems of chlorhexidine in a bio-absorbable chips for sustained release, this added benefits to SRP (16,17) .Another similar improvements were observed with adjunctive use of locally administrated microencapsulated tetracycline as minocycline (18,19) .…”

Section: …………………………………………………………………………………………………… Introduction:-mentioning

confidence: 70%

Evaluation of Topical Subgingival Application of Hyaluronic Acid (Ha) Gel Adjunctive to Scaling and Root Planing (Srp) in the Treatment of Chronic Periodontitis.

Kandil¹,

Khashaba²,

El-Daker³

et al. 2017

IJAR

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Objective: The aim of this study is to assess effect of sub-gingival application of hyaluronic acid (HA) gel .8% adjunctive to non-mechanical debridement in treatment of chronic periodontitis based on clinical scoring and microbiological study. Subjects and Methods: The present study was carried out on 20 patients with chronic periodontitis with at least two quadrants with pocket depth ≥5 mm within the same arch. Split-mouth study design was used where control side received (SRP) only and study side received both (SRP) and subgingival application of high molecular weight 0.8% hyaluronic acid gel in a 3 months follow-up study. After clinical assessment and plaque sample collection all patients received full mouth SRP in both study and control sites at the baseline, 2 nd , 4 th and 6 th weeks. Study sites additionally received 0.8% HMW HA gel sub-gingivally till the depth of pocket, this done once a week starting at the baseline then repeated at weeks 1, 2, 3, 4, 5 and 6 for a total seven applications. Subgingival plaque samples were collected prior to clinical measurements from both study and control sites at the baseline, 6 th and 12 th weeks for PCR examination. Evaluation included clinical and microbiological parameters that recorded at the base line, th 6 th and then in 12 th week. Clinical parameters included: Plaque index (PI), Gingival index(GI), Periodontal probing depths (PPD), Clinical attachment loss (CAL) and clinical attachment regain where, micriobiological assessment included qualitative polymerase chain reaction (PCR) for detection of both provotella intermedia and porphyromonus gingivalis in both sides . Results: In the present study, there were highly significant clinical improvements in all measured clinical

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Treatment of Periodontitis by Local Administration of Minocycline Microspheres: A Controlled Trial

Abstract: Scaling and root planing plus minocycline microspheres is more effective than scaling and root planing alone in reducing probing depths in periodontitis patients.

Cited by 198 publications

References 42 publications

Clinical and microbial evaluation of dental scaling associated with subgingival minocycline in chronic periodontitis subjects

Clinical and microbial evaluation of dental scaling associated with subgingival minocycline in chronic periodontitis subjects

Antibacterial Efficacy of Exogenous Nitric Oxide on Periodontal Pathogens

Evaluation of Topical Subgingival Application of Hyaluronic Acid (Ha) Gel Adjunctive to Scaling and Root Planing (Srp) in the Treatment of Chronic Periodontitis.

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