Treatment of periorbital infantile haemangiomas: A systematic literature review on propranolol or steroids

Xu, Shi-Qiong; Jia, Renbing; Ge, Shengfang; Lin, Ming Fong; Fan, Xianqun

doi:10.1111/jpc.12464

Cited by 22 publications

(14 citation statements)

References 67 publications

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“…Studies show that repeat injections of 20 mg of TA are required (one to four injections at monthly intervals) and the response rate is better in patients with recent onset of upper lid retraction or active disease. Xu et al noted an improvement in 83.3% of patients with symptom duration less than 6 months, compared to 36.4% who responded if symptoms were greater than 6 months. Joos et al showed that a superior orbital peri‐levator injection technique improved lid retraction and demonstrated reduction in size of the levator/superior rectus complex on MRI imaging after repeat injections.…”

Section: Uses Of Locally Administered Steroidsmentioning

confidence: 99%

Local delivery of corticosteroids in clinical ophthalmology: A review

Fung

Tran

Lim

et al. 2020

Clinical Exper Ophthalmology

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Locally administered steroids have a long history in ophthalmology for the treatment of inflammatory conditions. Anterior segment conditions tend to be treated with topical steroids whilst posterior segment conditions generally require periocular, intravitreal or systemic administration for penetration. Over recent decades, the clinical applications of periocular steroid delivery have expanded to a wide range of conditions including macular oedema from retino-vascular conditions. Formulations have been developed with the aim to provide practical, targeted, longer-term and more efficacious therapy whilst minimizing side effects. Herein, we provide a comprehensive overview of the

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Section: Uses Of Locally Administered Steroidsmentioning

confidence: 99%

Local delivery of corticosteroids in clinical ophthalmology: A review

Fung

Tran

Lim

et al. 2020

Clinical Exper Ophthalmology

View full text Add to dashboard Cite

show abstract

“…In addition, in meta-analysis of 16 studies (2,629 cases) and 25 studies (795) published in 1965-2012, 69% of the patients responded to 12-month corticosteroid therapy, but the response rate to propranolol was 97% with a significant difference. 191 In periorbital hemangiomas, the response rate to propranolol was found to be significantly higher than that to corticosteroid by meta-analysis of papers published before 2013, 192 and propranolol showed the strongest effect against airway hemangiomas compared with steroid, CO 2 laser, and vincristine on meta-analysis. 193,194 From these observations, we concluded that propranolol was significantly more effective than placebo and to be similarly effective compared with corticosteroid.…”

Section: Cq14: Is Propranolol Safe and Effective For Infantile Hemangmentioning

confidence: 99%

Japanese clinical practice guidelines for vascular anomalies 2017

Mimura

Akita

Fujino

et al. 2020

Pediatrics International

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The objective was to prepare guidelines to perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas and vascular malformations, confirming the safety, and systematizing treatment, employing evidence‐based medicine (EBM) techniques and aimed at improvement of the outcomes. Clinical questions (CQs) were decided based on the important clinical issues. For document retrieval, key words for literature searches were set for each CQ and literature published from 1980 to the end of September 2014 was searched in Pubmed, Cochrane Library, and Japana Centra Revuo Medicina (JCRM). The strengths of evidence and recommendations acquired by systematic reviews were determined following the Medical Information Network Distribution System (MINDS) technique. A total of 33 CQs were used to compile recommendations and the subjects included efficacy of resection, sclerotherapy/embolization, drug therapy, laser therapy, radiotherapy, and other conservative treatment, differences in appropriate treatment due to the location of lesions and among symptoms, appropriate timing of treatment and tests, and pathological diagnosis deciding the diagnosis. Thus, the Japanese Clinical Practice Guidelines for Vascular Anomalies 2017 have been prepared as the evidence‐based guidelines for the management of vascular anomalies.

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“…In addition, in a meta-analysis of 16 studies (2629 cases) and 25 studies (795 cases) published in 1965-2012, 69% of the patients responded to 12-month corticosteroid therapy, but the response rate to propranolol was 97% with a significant difference. 191 In periorbital hemangiomas, the response rate to propranolol was found to be significantly higher than that to corticosteroid by meta-analysis of papers published before 2013, 192 and propranolol showed the strongest effect against airway e150…”

Section: E149mentioning

confidence: 99%

Japanese Clinical Practice Guidelines for Vascular Anomalies 2017

Mimura

Akita

Fujino

et al. 2020

The Journal of Dermatology

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The objective was to prepare guidelines to perform the current optimum treatment by organizing effective and efficient treatments of hemangiomas and vascular malformations, confirming the safety and systematizing treatment, employing evidence-based medicine techniques and aimed at improvement of the outcomes. Clinical questions (CQ) were decided based on the important clinical issues. For document retrieval, key words for published work searches were set for each CQ, and work published from 1980 to the end of September 2014 was searched in PubMed, Cochrane Library and Japana Centra Revuo Medicina databases. The strengths of evidence and recommendations acquired by systematic reviews were determined following the Medical Information Network Distribution System technique. A total of 33 CQ were used to compile recommendations and the subjects included efficacy of resection, sclerotherapy/embolization, drug therapy, laser therapy, radiotherapy and other conservative treatment, differences in appropriate treatment due to the location of lesions and among symptoms, appropriate timing of treatment and tests, and pathological diagnosis deciding the diagnosis. Thus, the Japanese Clinical Practice Guidelines for Vascular Anomalies 2017 have been prepared as the evidence-based guidelines for the management of vascular anomalies.

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Treatment of periorbital infantile haemangiomas: A systematic literature review on propranolol or steroids

Abstract: Propranolol may represent an effective therapy for periorbital IHs compared with the use of corticosteroids; however, further randomised control studies are needed to compare adverse events.

Cited by 22 publications

References 67 publications

Local delivery of corticosteroids in clinical ophthalmology: A review

Local delivery of corticosteroids in clinical ophthalmology: A review

Japanese clinical practice guidelines for vascular anomalies 2017

Japanese Clinical Practice Guidelines for Vascular Anomalies 2017

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