Cleaner production is the key to environmental sustainability. Conversion of crude oil to various beneficial products is responsible for the contamination of air, water, and soil which are harmful to human, plants, animals, public health and the environment. Adequately treating produced water is beneficial for irrigation, wildlife consumption, industrial water and for domestic purposes. Therefore, green technology for treatment of crude oil processed water would provide the environmental friendliness needed for prolong utilization of our natural resources. Hence, the aim of this book chapter is to investigate the potentials of constructed wetland as a promising, effective and environmentally friendly alternative for secondary petroleum refinery wastewater treatment. Planted and unplanted mesocosm scale experiment with real secondary refinery wastewater was used for the purpose of the study. The parameters investigated were temperature, pH, dissolved oxygen, electrical conductivity, total suspended solids, carbon oxygen demand, total petroleum hydrocarbon and oil and grease. The results revealed that Typha latifolia planted VSSF CWs effectively treated organic contaminants in secondary refinery wastewater with a better performance than the unplanted control VSSF CWs. The chromatographs for wastewater and T. latifolia samples showed a hydrocarbon distribution between n-C9 to n-C24 indicating abundance of lower weight hydrocarbon contamination.