Treatment of plasma cell cheilitis with griseofulvin

Tamaki, Kunihiko; Osada, Atsushi; Tsukamoto, Katsuhiko; Ohtake, Naoto; Furue, Masutaka

doi:10.1016/s0190-9622(08)81515-0

Cited by 31 publications

(22 citation statements)

References 4 publications

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“…Unlike the cases reported by Jones and Kennedy 5 and Tamaki et al ., 6 our patient responded only partially to treatment with a highly potent topical corticosteroid and no additional benefit was obtained with the association of oral griseofulvin. Alternative treatments such as surgical excision, radiotherapy and liquid nitrogen have previously been shown to be effective, however, our patient refused further therapy.…”

Section: Discussioncontrasting

confidence: 88%

Plasma cell cheilitis

Rocha

Mota

Horta

et al. 2003

Acad Dermatol Venereol

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Plasma cell cheilitis is a rare inflammatory disorder of the lip with a characteristic band-like infiltrate of plasma cells in the upper dermis. Differential diagnosis should consider allergic/irritant contact cheilitis, candidiasis, syphilis, Queyrat's erythroplasia, granulomatous cheilitis, plasmoacanthoma, plasmacytoma, squamous cell carcinoma and exfoliative or factitious cheilitis. We observed plasma cell cheilitis in a 60-year-old Caucasian female who had a partial response to topical steroids and oral griseofulvin.

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Section: Discussioncontrasting

confidence: 88%

Plasma cell cheilitis

Rocha

Mota

Horta

et al. 2003

Acad Dermatol Venereol

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“…Although there are various possible treatments for plasma cell cheilitis, phototherapy has never been reported as a treatment option. We present here the first case of plasma cell cheilitis treated with 308‐nm MEL.…”

Section: Discussionmentioning

confidence: 99%

Successful treatment with 308‐nm monochromatic excimer light and subsequent tacrolimus 0.03% ointment in refractory plasma cell cheilitis

Yoshimura

Nakano²,

Tsuruta

et al. 2013

The Journal of Dermatology

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Plasma cell cheilitis is a chronic inflammatory disease that presents with erythema, erosions, ulcers and occasional nodules within the mucosa, including the lips. It is histopathologically characterized by dense plasma cell infiltration in the lamina propria of the mucous membranes. Several treatments for plasma cell cheilitis have been reported, including topical steroids, topical antibiotics or topical tacrolimus. However, 308-nm monochromatic excimer light (MEL) has never been reported as a treatment option, while it was reported to be very effective in treating erosive oral lichen planus. We report a 62-year-old man who had chronic plasma cell cheilitis on the lower lip, which was refractory to topical and systemic corticosteroid. The lesion and severe pain were significantly improved by the treatment with nine sessions of 308-nm MEL twice per week with a total dose of 1120 mJ/cm(2). However, the lesion gradually worsened after treatment frequency was reduced to once per month. Subsequent tacrolimus 0.03% ointment cleared the lesion completely in a month and no recurrence was observed a year later. Refractory plasma cell cheilitis and concomitant severe pain quickly responded to 308-nm MEL when administrated twice per week. Because the long interval between each MEL treatment seemed ineffective to improve the lesion, appropriate frequency and adequate total dose of MEL treatment may be necessary for a successful treatment.

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“…Besides the lips, lesions can also occur in other organs, such as the penis, vulva, buccal mucosa, palate, gingiva, tongue, epiglottis and larynx. 2,5 White et al 2 proposed 'plasma-cell orificial mucositis' to encompass the various names given to the shared condition at different body sites.…”

Section: Reportmentioning

confidence: 99%

“…2,6,8 Various other treatments have been recommended, including surgical excision, radiation treatment, electrocauterization, cryotreatment, topical fusidic acid and systemic administration of griseofulvin. 5,6 The degree of acanthosis seems to be an important factor influencing treatment outcomes in those who respond to topical corticosteroids. Different results with topical corticosteroids have been reported for atrophic, mildly acanthotic and markedly acanthotic variants.…”

Section: Reportmentioning

confidence: 99%

Plasma-cell cheilitis: successful treatment with intralesional injections of corticosteroids

Tseng

Cheng

Lee

et al. 2009

Clinical and Experimental Dermatology

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Plasma-cell cheilitis is a rare inflammatory disorder of the lip characterized histologically by a band-like infiltrate of plasma cells in the upper dermis. It is considered an oral counterpart of plasma-cell balanitis. Clinically, it presents as a circumscribed, flat to slightly raised, eroded area of the lip. The cause of plasma-cell cheilitis is unknown, and the treatment is often disappointing. We describe a 55-year-old woman who had a long-lasting painful, swollen, and eroded area on her lips, which responded poorly to various topical treatments. Biopsy showed a band-like infiltrate composed mainly of mature plasma cells in the dermis. A diagnosis of plasma-cell cheilitis was made after excluding contact dermatitis, lichen planus, bacterial, fungal and spirochaete infections, and an extramedullary plasmacytoma. Dramatic improvements were observed after intralesional injections of corticosteroids. The lesion cleared up after two treatments, and there has been no recurrence in 1 year of follow-up.

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Treatment of plasma cell cheilitis with griseofulvin

Cited by 31 publications

References 4 publications

Plasma cell cheilitis

Plasma cell cheilitis

Successful treatment with 308‐nm monochromatic excimer light and subsequent tacrolimus 0.03% ointment in refractory plasma cell cheilitis

Plasma-cell cheilitis: successful treatment with intralesional injections of corticosteroids

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