Treatment of polycystic ovary patients undergoing IVF

Barri, P. N.; Coroleu, Buenaventura; Martínez, Francisca; Traver, J. M.; Veiga, Anna; Calderón, Gloria

doi:10.1007/bf02765743

Cited by 5 publications

(1 citation statement)

References 15 publications

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“…Pentoxifylline has anti-angiogenic effects and has been postulated to lead to endometriosis lesion regression [ 65 ]. Some studies have suggested that pentoxifylline may improve oocyte quality, fertilization rates, and embryo development in women with endometriosis [ 66 , 67 ], whereas others have found no beneficial effect on oocyte and embryo quality [ 68 , 69 ]. The effects of pentoxifylline have been evaluated in a recent Cochrane systematic review based on three randomized controlled trials in 285 patients, which showed that overall the evidence for the effect of pentoxifylline versus placebo on clinical pregnancy rates is uncertain, and there are no trials that have reported on the effects of pentoxifylline on live birth rate [ 70 ].…”

Section: Management Optionsmentioning

confidence: 99%

Endometriosis, Oocyte, and Embryo Quality

Latif

Sarıdoğan

2023

JCM

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Endometriosis is a common finding among women with infertility, and women who are diagnosed with endometriosis are almost twice as likely to experience infertility. Mechanisms by which endometriosis causes infertility remain poorly understood. In this review, we evaluate the current literature on the impact of endometriosis on oocyte and embryo quality. The presence of endometriosis evidently reduces ovarian reserve, oocyte quality, and embryo quality; however, this does not appear to translate to a clear clinical impact. Analysis of data from large assisted reproduction technology registries has shown that women with endometriosis have a lower oocyte yield but no reduction in reproductive outcomes. There is a need for future studies in the form of well-designed randomized controlled trials to further evaluate the role of surgical and medical treatment options in women with endometriosis undergoing assisted conception.

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