Treatment of preadipocytes with fish oil, mixed oil, or soybean oil-based lipid emulsions have differential effects on the regulation of lipogenic and lipolytic genes in mature 3T3-L1 adipocytes

Isesele, Peter; Vaidya, Hitesh; Gill, Renu; Cheema, Sukhinder Kaur

doi:10.1016/j.plefa.2022.102396

Cited by 2 publications

(1 citation statement)

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“…However, results from clinical studies can be contradictory with some showing no impact on disease symptoms. in vitro analysis demonstrates that fish oil treatment can reduce expression of genes involved in adipogenesis, lipogenesis and β‐oxidation of fatty acids (Isesele et al., 2022 ). Further, there is evidence that increased maternal n −3 PUFA concentrations in the plasma have impacts on SAT in infants (Jelena Vidakovic et al., 2016 ).…”

Section: Dietary Interventionsmentioning

confidence: 99%

Developmentally programmed obesity: Is there a role for anti‐inflammatory nutritional strategies?

Kearns,

Reynolds

2023

Experimental Physiology

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Pregnancy represents a period of immense maternal physiological adaptation, with progressive increases in lipid storage potential and insulin resistance to support fetal/placental growth. This requires significant change in the adipose tissue. Women living with obesity/overweight are more susceptible to these changes causing complications such as gestational diabetes. This is particularly worrying as up to 60% of European women are living with overweight/obesity at the onset of pregnancy. Furthermore, less than 1% meet all nutrition guidelines. There is now evidence that these deep metabolic changes can result in a predisposition to metabolic disease in both the mother and child in later life. Health and nutrition status during this period therefore represents a window to future health. This period offers a valuable opportunity for intervention to prevent the negative consequences of poor in utero environments and increases the long‐term quality of life for mother and offspring. This review will examine a range of in utero factors which determine adipose tissue development, the impact of these factors on later‐life obesity and metabolic health and the therapeutic value of dietary anti‐inflammatory nutritional interventions during pregnancy and early life. When it comes to early life nutrition, a ‘one size fits all’ approach is not always appropriate. Understanding the mechanisms of adipose tissue development in response to differing nutritional strategies may be important in the context of complicated or adverse in utero environments and represents a substantial step towards a more personalised nutritional approach for the prevention of obesity, metabolic syndrome and related non‐communicable diseases in future generations.

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Section: Dietary Interventionsmentioning

confidence: 99%