Treatment of primary cardiac angiosarcoma in a 35 weeks pregnant woman

Abstract

Background Cardiac angiosarcoma is a rare but highly malignant cardiac tumor. It is characterized by poor prognosis, and current treatment approaches are not effective. Case presentation A 37‐year‐old female with 35 weeks pregnancy experienced chest tightness and shortness of breath for 1 month. She was diagnosed with primary cardiac angiosarcoma. Delivery of fetus was performed early to treat the mother. The patient underwent resection of the tumor then she was treated with chemotherapy. However, the tumor recurred 11 months after surgery. Conclusion Angiosarcoma is a highly malignant tumor explaining recurrence of the tumor recurred after surgery. Cardiac angiosarcoma should be treated through a comprehensive treatment plan, comprising surgery, radiotherapy, and chemotherapy approaches.

Multi‐disciplinary frameworks for the treatment of primary cardiac sarcoma

“…However, The Journal of Cardiac Surgery continues to experience a surge in case submissions and case complexity as represented by this case report. The authors note that it is challenging to “cure the mother or keep the baby during surgery.” 1 This report underscores the importance of a multidisciplinary approach to complex cases, in particular in the case of a patient presenting with a cardiac tumor, especially a potentially malignant one. The authors are to be congratulated with successfully integrating multiple specialties, allowing survival of both the patient and off‐spring.…”

Case Report: Assessment of primary myxofibrosarcoma in the left atrium using multimodal ultrasonography

“…Moreover, it also inhibits RTKs involved in other proangiogenic and tumorigenic pathways, including fibroblast growth factor (FGF), receptors FGFR1, 2, 3, and 4, and platelet-derived growth factor (PDGF) receptors PDGFRa, KIT, and RET. According to case reports and guidelines, the most widely adopted treatment strategies are surgery combined with chemotherapy and targeted anti-tumor drugs (3,7,8,10). However the outcomes are not satisfactory, the median survival for patients that had complete surgical resection was 17 months compared to 6 months with incomplete resection.…”

“…Primary cardiac myxofibrosarcoma is very aggressive. Although only a few cases have been reported, studies have shed light on clinical presentation, pathological features, and treatment strategies (4)(5)(6)(7). Moreover, the diagnostic value of ultrasonography, particularly cardiac contrast echocardiography, has not been widely discussed.…”