Treatment of primary cutaneous anaplastic large cell lymphoma

Abstract

Primary cutaneous anaplastic large cell lymphoma (C-ALCL) is a rare subtype of primary cutaneous lymphoma with a favorable prognosis. Primary cutaneous CD30+ lymphoproliferative disorders, which include C-ALCL and lymphomatoid papulosis, are the second most common group of cutaneous T-cell lymphomas. C-ALCL is comprised of large cells with anaplastic, pleomorphic, or immunoblastic cytomorphology, and indeed, more than 75% of the tumor cells express the CD30 antigen. C-ALCL clinically presents with solitary or localized reddish-brown nodules or tumors, and sometimes indurated papules, and they may be with ulceration covering with dark eschar. Multifocal lesions are seen in 20% of the patients. Extracutaneous dissemination, which mainly involves the regional lymph nodes, occurs in 10% of patients. A 69-year-old man noticed a mild elevated cutaneous lesion containing central ulceration covering with brownish black necrotic tissue on the right lower lip, and the lesion was surgically removed. After the first operation, another skin lesion was developed and the histological examination confirmed the diagnosis, C-ALCL. Eight specimens were excised during the 7-month follow-up period. The patient started the treatment with low-dose oral methotrexate (15 mg/wk) and there was no recurrence for 11 months.

Early diagnosis and surgical treatment of primary cutaneous marginal zone B-cell lymphomas of the face in an Asian patient

“…PCMZL is a subgroup of primary cutaneous B-cell lymphomas, which belong to the larger category of extranodal B-cell non-Hodgkin lymphoma [6,7]. PCMZL accounts for about 2-7% of PCMZL most often occurs in middle-aged adults, and its incidence is higher in men than in women [1,2].…”

“…PCMZL is a subgroup of primary cutaneous B-cell lymphomas, which belong to the larger category of extranodal B-cell non-Hodgkin lymphoma [ 6 , 7 ]. PCMZL accounts for about 2-7% of all primary cutaneous lymphomas [ 1 , 8 ].…”

Cutaneous Anaplastic Large Cell Lymphoma: A Case Report about Masking Effect of Facial Masks in the COVID-19 Pandemic

“…Surgical excision of a solitary PC-ALCL can be definitive treatment, such as in this case, whereas multiple lesions, secondary lesions, or systemic disease may require chemotherapy and/or radiotherapy. 9,10…”

Pruritic Erythroderma and Disseminated Ulcers

“…Methotrexate or systemic retinoid may be considered when only the skin is committed in multifocal segments. After remission, clinical follow-up is warranted as cutaneous recurrences are frequent (Baik et al, 2019;Shehan et al, 2004).…”