2023
DOI: 10.1002/ccr3.6885
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Treatment of primary eosinophilic colitis using immunoglobulin/histamine complex

Abstract: Primary eosinophilic colitis (PEC) is a primary eosinophilic gastrointestinal disorder, and immunoglobulin/histamine complex (IHC) may be an effective therapeutic for PEC. IHC has a nonallergen‐specific antinociceptive effect in the treatment of histamine‐mediated pain.

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“…A phase 2 clinical trial is actively recruiting participants to investigate the efficacy and safety of dupilumab therapy compared with placebo in patients with moderately to severely active ulcerative colitis with an eosinophilic phenotype [152]; in the case of success, dupilumab may also be considered for the treatment of EoC in the future. Recently, a patient with EoC was successfully treated with the immunoglobulin/histamine complex (IHC, Histobulin) subcutaneously once a week for 10 weeks with concomitant tapering and suspension of oral corticosteroids [153].…”
Section: Emerging Therapiesmentioning
confidence: 99%
“…A phase 2 clinical trial is actively recruiting participants to investigate the efficacy and safety of dupilumab therapy compared with placebo in patients with moderately to severely active ulcerative colitis with an eosinophilic phenotype [152]; in the case of success, dupilumab may also be considered for the treatment of EoC in the future. Recently, a patient with EoC was successfully treated with the immunoglobulin/histamine complex (IHC, Histobulin) subcutaneously once a week for 10 weeks with concomitant tapering and suspension of oral corticosteroids [153].…”
Section: Emerging Therapiesmentioning
confidence: 99%