Treatment of prostatitis in the rat

Lundgren, Rolf; Holmquist, Björn; Hesselvik, Margareta; Müntzing, Jonas

doi:10.1002/pros.2990050305

Cited by 39 publications

(20 citation statements)

References 19 publications

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“…Rat prostatitis is similar to the human condition and these findings support the hypothesis that corticosteroids should be further evaluated as a treatment option. 12 We were unsuccessful in finding any other references on a search of Medline, the Science Citation Index, Embase, or the Cochrane Library.…”

Section: Discussionmentioning

confidence: 99%

Short course oral prednisolone therapy in chronic abacterial prostatitis and prostatodynia: case reports of three responders and one non-responder

Bates

2000

Sexually Transmitted Infections

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Objective: To report on a small group of patients with chronic abacterial prostatitis/chronic pelvic pain syndrome treated with oral corticosteroids in order to suggest a hypothesis for a future randomised controlled trial. Design: A retrospective, observational report. Results: Three out of the four patients reported improvement in symptoms following steroid treatment. Conclusions: These reports suggest that there is scope for conducting a randomised, placebo controlled study to investigate the role of oral corticosteroids in patients with chronic abacterial prostatitis/chronic pelvic pain syndrome who have failed on conventional therapy. (Sex Transm Inf 2000;76:398-400)

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Section: Discussionmentioning

confidence: 99%

Short course oral prednisolone therapy in chronic abacterial prostatitis and prostatodynia: case reports of three responders and one non-responder

Bates

2000

Sexually Transmitted Infections

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“…Naslund et al5 reported that spontaneously-developed prostatitis and E2-induced prostatitis in Wistar rats had the same histologic findings. Other studies have demonstrated that spontaneous nonbacterial prostatitis in rats was histologically very similar to CP in humans 7,8…”

Section: Introductionmentioning

confidence: 88%

The Anti-Inflammatory Effects of a New Herbal Formula (WSY-1075) in a Nonbacterial Prostatitis Rat Model

Yoon

Bae

Kim

et al. 2013

World J Mens Health

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PurposeThe aim of this study was to investigate the anti-inflammatory effects of a new herbal formula (WSY-1075) in a nonbacterial prostatitis rat model.Materials and MethodsProstatitis was induced in male Wistar rats (n=32) by treatment with 17 beta-estradiol and dihydrotestosterone for 4 weeks. After the induction of prostatitis, the rats were randomly divided into one of four treatment groups: control (n=8), ciprofloxacin (n=8), WSY-1075 (100 mg/kg) (n=8), and WSY-1075 (400 mg/kg) (n=8). After 4 weeks of treatment, the prostatic proinflammatory cytokine (tumor necrosis factor-α, interleukin [IL]-6, and IL-8) levels and histological findings were noted.ResultsThe ciprofloxacin and WSY-1075 treatment groups showed significantly decreased proinflammatory cytokine levels compared with the control group. Histologically, treatment with ciprofloxacin and WSY-1075 significantly suppressed the severity of prostatitis lesions compared with those in the control group. No differences in the proinflammatory cytokine levels or histologic findings were observed with the dose dependent treatment of WSY-1075.ConclusionsThe new herbal formula, WSY-1075, showed effective anti-inflammatory activities in the prostate and may be useful for the clinical treatment of nonbacterial prostatitis. Our findings suggest that WSY-1075 has a beneficial effect on the prevention and treatment of nonbacterial prostatitis.

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“…This is an inflammatory process localized primarily in the lateral lobe of the rat prostate, with which steroid hormones may be associated [86, 87]. Rats maintained on a soya-free diet for 11 weeks developed severe inflammation in the lateral prostate, whereas rats maintained on a diet with adequate soya, or commercial rat chow which contains soya, did not develop any signs of prostatitis.…”

Section: Prostatitis and Dietary Factorsmentioning

confidence: 99%