1975
DOI: 10.1111/1523-1747.ep12610346
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Treatment Of Psoriasis With Oral Mycophenolic Acid

Abstract: Mycophenolic acid (MPA), an inhibitor of purine synthesis, was evaluated for its therapeutic and adverse effects in 29 patients with psoriasis. MPA was administered orally for at least 12 weeks, during which time the daily dose was increased from 1600 to 4800 mg depending on occurrence of adverse reactions. Complete clearing occurred in 1 of the patients, almost complete clearing in 14, definite improvement in 13, slight or doubtful improvement in 1. The full effect of MPA required a median time of 8 weeks (ra… Show more

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Cited by 105 publications
(37 citation statements)
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“…The toxicity of mycophenolic acid for humans has been variously reported. Several studies showed only mild gastrointestinal distress and none-tomild hematological disturbances (6,8,11,13,17), but one study showed significant hematological toxicity (15). The further implication of these experiments is that inhibitors of guanosine nucleotide synthesis may be attractive candidates for antileishmanial agents.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…The toxicity of mycophenolic acid for humans has been variously reported. Several studies showed only mild gastrointestinal distress and none-tomild hematological disturbances (6,8,11,13,17), but one study showed significant hematological toxicity (15). The further implication of these experiments is that inhibitors of guanosine nucleotide synthesis may be attractive candidates for antileishmanial agents.…”
Section: Resultsmentioning
confidence: 99%
“…Marr and colleagues have shown that allopurinol or its derivatives may be effective antileishmanial agents due to parasite-specific incorporation of such compounds into adenosine metabolites (3,18). Mycophenolic acid prevents the conversion of IMP to GMP in Landschutz ascites cells, calf thymus, and LS cells (7) and has been used experimentally for the oral treatment for psoriasis (8,11,15,17). Here we demonstrate that mycophenolic acid and allopurinol are both partially effective antileishmanial agents in the human macrophage model of leishmaniasis.…”
mentioning
confidence: 99%
“…Safety (hematology and biochemistry, including serum protein electrophoresis, immunophenotyping, and urine studies), immunogenicity, pharmacokinetic, and biologic activity assessments (antibody titers; Physician's Global Assessment) were performed at each of these scheduled visits. The Physician's Global Assessment, an evaluation of the extent/worsening of the patient's condition relative to pretreatment, was performed in the traditional manner employing a 7-point scale, with the degree of improvement compared with baseline evaluation denoted in the following manner: 0 = 100%, completely clear; 1 = 90%; 2 = 75%; 3 = 50%; 4 = 25%; 5 = 0%; 6 = deterioration (24).…”
Section: Figurementioning
confidence: 99%
“…These findings have been supported by several studies including open-label, longterm studies and a multicenter, double-blind, placebocontrolled trial. [3][4][5][6][7][8] The questionable increased incidence of carcinogenicity and latent viral infections associated with the use of mycophenolic acid discouraged the continuation of studies of this drug for psoriasis. Careful review of these data demonstrated that all patients with psoriasis who developed herpes zoster infection and other viral and bacterial infections during therapy with mycophenolic acid had uncomplicated infectious disease and had been receiving dosages of mycophenolic acid higher than 3 g/d.…”
Section: Commentmentioning
confidence: 99%