Treatment of Psoriatic Nails with Topical Cyclosporin: A Prospective, Randomized Placebo-Controlled Study

Cannavò, Salvatore; Guarneri, Fabrizio; Vaccaro, Mario; Borgia, Francesco; Guarneri, Biagio

doi:10.1159/000068469

Cited by 83 publications

(70 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Encouraging results have been reported with topical and intralesional steroids when the matrix is affected [6], while cyclosporine solution is more effective in cases of nail bed psoriasis [7]. Topical tazarotene has been reported to be effective in ameliorating both matrix and nail bed signs [8].…”

Section: Discussionmentioning

confidence: 99%

Treatment of Nail Psoriasis with a Two-Compound Formulation of Calcipotriol plus Betamethasone Dipropionate Ointment

Rigopoulos¹,

Gregoriou²,

Daniel

et al. 2009

Dermatology

View full text Add to dashboard Cite

Background: Treatment of nail psoriasis remains a challenge. Objective: To evaluate the efficacy of a two-compound product of calcipotriol plus betamethasone dipropionate ointment on nail psoriasis in an open-label study. Methods: Twenty-five psoriatic patients with nail involvement and mild cutaneous psoriasis were instructed to apply a calcipotriol-betamethasone valerate ointment formulation once daily for 12 weeks on affected nails. Outcome measures were assessed at baseline and at weeks 4, 8 and 12 using the nail psoriasis severity index (NAPSI). Results: Twenty-two patients having 114 nails involved at baseline with a mean NAPSI of 5.8 ± 1.7 were followed up for 12 weeks. The mean NAPSI at the end of the treatment period was reduced to 1.6 ± 0.6 presenting a 72% improvement. Significant improvement was observed for hyperkeratosis and onycholysis (reduction of mean hyperkeratosis NAPSI from 2.2 ± 0.5 to 0.5 ± 0.1 and mean onycholysis NAPSI from 2.0 ± 0.6 to 0.4 ± 0.2), moderate improvement for oil drops (reduction of mean oil drop NAPSI from 1.2 ± 0.4 to 0.8 ± 0.3) and slight improvement for pitting (reduction of mean pitting NAPSI from 0.8 ± 0.2 to 0.6 ± 0.2). Conclusions: The calcipotriol plus betamethasone dipropionate two-compound ointment, applied once daily for 12 weeks, was shown to improve nail psoriasis.

show abstract

Section: Discussionmentioning

confidence: 99%

Treatment of Nail Psoriasis with a Two-Compound Formulation of Calcipotriol plus Betamethasone Dipropionate Ointment

Rigopoulos¹,

Gregoriou²,

Daniel

et al. 2009

Dermatology

View full text Add to dashboard Cite

show abstract

“…Psoriasiste tırnak tutulumu şiddetini ölçmek için geliştirilmiş birçok indeks bulunmaktadır (Tırnak Psoriasisi Şiddet İndeksi (NAPSI), modifiye NAPSI, hedef NAPSI, Tırnak Alan Şiddeti, Psoriasis Tırnak Şiddet Skoru, Baran'ın sistemi, Cannavo'nun sistemi ve Nijmegen-Tırnak Psoriasis Aktivite İndeksi) [107][108][109][110][111][112][113] .…”

Section: Tırnak Psoriasisiunclassified

Disease severity scoring systems in dermatology

Bilaç¹,

Şahin²,

Öztürkcan³

2016

TURKDERM

View full text Add to dashboard Cite

Scoring systems have been developed to interpret the disease severity objectively by evaluating the parameters of the disease. Body surface area, visual analogue scale, and physician global assessment are the most frequently used scoring systems for evaluating the clinical severity of the dermatological diseases. Apart from these scoring systems, many specific scoring systems for many dermatological diseases, including acne (acne vulgaris, acne scars), alopecia (androgenetic alopecia, tractional alopecia), bullous diseases (autoimmune bullous diseases, toxic epidermal necrolysis), dermatitis (atopic dermatitis, contact dermatitis, dyshidrotic eczema), hidradenitis suppurativa, hirsutismus, connective tissue diseases (dermatomyositis, skin involvement of systemic lupus erythematosus (LE), discoid LE, scleroderma), lichen planoplaris, mastocytosis, melanocytic lesions, melasma, onychomycosis, oral lichen planus, pityriasis rosea, psoriasis (psoriasis vulgaris, psoriatic arthritis, nail psoriasis), sarcoidosis, urticaria, and vitiligo, have also been developed. Disease severity scoring methods are ever more extensively used in the field of dermatology for clinical practice to form an opinion about the prognosis by determining the disease severity; to decide on the most suitable treatment modality for the patient; to evaluate the efficacy of the applied medication; and to compare the efficiency of different treatment methods in clinical studies. Keywords: Disease severity, scoring system, dermatology Skorlama sistemleri, hastalığa ait parametrelerin değerlendirilerek hastanın klinik şiddetini objektif olarak saptama amacıyla geliştirilmiş olan ölçeklerdir. Vücut yüzey alanı, görsel analog skala ve doktor global değerlendirme skoru dermatolojik hastalıkların klinik şiddetinin değerlendirilmesi amacıyla en sık kullanılan genel skorlama sistemleridir. Bu skorlama sistemleri dışında akne (akne vulgaris, akne skarları), alopesi (androgenetik alopesi, traksiyonel alopesi), Behçet hastalığı, büllöz hastalıklar (otoimmün büllöz hastalıklar, toksik epidermal nekroliz, epidermolizis bülloza), dermatit (atopik dermatit, kontakt dermatit, dishidrotik egzama), hidradenitis suppurativa, hirsutismus, konnektif doku hastalıkları (dermatomyozit, sistemik lupus eritematozusun (LE) deri tutulumu, diskoid LE, skleroderma), liken planopilaris, mastositoz, melanositik lezyonlar-melanom, melazma, mikozis fungoides/Sezary sendromu, onikomikoz, oral liken planus, pitiriyazis rozea, psoriasis (psoriasis vulgaris, psoriatik artrit, tırnak psoriasisi), sarkoidoz, ürtiker ve anjiyoödem ve vitiligo gibi çok sayıda dermatolojik hastalık için spesifik skorlama sistemleri de geliştirilmiştir. Hastalık şiddet skorlama yöntemleri, dermatoloji alanında klinik pratikte hastalığın şiddetinin belirlenerek prognoz hakkında fikir sahibi olunabilmesi, hasta için uygun tedavinin belirlenmesi, uygulanan tedavinin etkinliğinin değerlendirilmesi, klinik araştırmalarda ise farklı tedavi yöntemlerinin etkinliklerinin karşılaştırılabilmesi gibi amaçlarla giderek d...

show abstract

“…A variety of systems have been established to evaluate nail psoriasis, including Baran’s nail psoriasis severity index [15], Cannavò’s scoring system [16] and the nail psoriasis quality of life scale (NPQ10) [17]. The Nail Psoriasis Severity Index (NAPSI) is a reproducible, objective and simple tool for the clinical assessment of psoriatic nail disease and is the only clinical scale that has been validated [18].…”

Section: Introductionmentioning

confidence: 99%

Methods of Outcomes Measurement in Nail Psoriasis

Augustin¹,

Ogilvie²

2010

Dermatology

View full text Add to dashboard Cite

Background: Nail involvement is a common feature of psoriasis, predicting higher disease severity and greater impairment in quality of life. Valid assessment of nail psoriasis is relevant for research and routine clinical use. However, no measurement standards have currently been developed. Objective: To identify state-of-the-art outcomes measurements in nail psoriasis by literature analysis. Methods: Systematic Web-based literature search, followed by structured critical appraisal and consecutive descriptive report. The search focused on methodological and epidemiological publications and papers describing outcomes of clinical trials on nail psoriasis. Results: Initially, 646 publications met the primary criteria. After non-relevant or replicate publications were excluded, 66 papers were analysed, including clinical trials or case reports (n = 41), reviews (n = 11) and methodological or epidemiological studies (n = 14). In total, 23 clinical outcomes measures and 15 patient-reported outcomes (PRO) tools were used. None had been validated according to recent standards. In the studies with clinical interventions (n = 41), NAPSI (Nail Psoriasis Severity Index; n = 4) or target NAPSI (n = 2) were the most often used single tools, followed by Physician’s Global Assessment (n = 3). However, in 16 studies, no specifically described outcomes measures were used. Conclusion: Valid clinical outcomes measures in nail psoriasis are rare. Existing tools lack validation and standardisation. A need exists for accurate and scientifically sound evaluation of nail psoriasis severity in trials and clinical practice. To cover all elements of nail psoriasis, the optimal nail psoriasis assessment tool would include both PRO and physician-assessed outcomes measures.

show abstract

Treatment of Psoriatic Nails with Topical Cyclosporin: A Prospective, Randomized Placebo-Controlled Study

Cited by 83 publications

References 3 publications

Treatment of Nail Psoriasis with a Two-Compound Formulation of Calcipotriol plus Betamethasone Dipropionate Ointment

Treatment of Nail Psoriasis with a Two-Compound Formulation of Calcipotriol plus Betamethasone Dipropionate Ointment

Disease severity scoring systems in dermatology

Methods of Outcomes Measurement in Nail Psoriasis

Contact Info

Product

Resources

About