Treatment of Recalcitrant Eosinophilic Cellulitis With Adalimumab

Sarin, Kavita Y.; Fiorentino, David

doi:10.1001/archdermatol.2012.114

Cited by 6 publications

(4 citation statements)

References 16 publications

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“…reported on a 45‐year‐old female patient not tolerating oral steroids and failing other therapies such as dapsone, azathioprine, antihistamines and colchicine. Her lesions resolved after 1 month of therapy with 40 mg adalimumab per week . After discontinuation, the lesions recurred and completely resolved again when the therapy was re‐induced.…”

Section: Resultsmentioning

confidence: 99%

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Treatment of eosinophilic cellulitis (Wells syndrome) – a systematic review

Räßler

Lukács

Elsner

2016

Acad Dermatol Venereol

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Eosinophilic cellulitis (Wells syndrome) is a rare inflammatory skin disease defined by erythematous, tender, sometimes urticarial plaques, possibly with vesicles and bullae, and granulomatous eosinophilic infiltrates in the dermis. Usually the disease has a benign course with spontaneous remission within a few weeks. Nevertheless, recurrences are quite frequent and may occur for several years. The objective of this study was to review the so far reported treatment options for Wells syndrome in a systematic manner. This systematic review is based on a search on Medline, Embase and Cochrane Central Register for English and German articles from 1970 to 2015. Advices on the treatment of Wells syndrome are limited predominately to case reports or to small case series. There are no randomized controlled trials, and control groups are missing. A variety of treatment options for Wells syndrome were reported including topical and systemic corticosteroids, antihistamines, cyclosporine, dapsone, azathioprine, griseofulvin, doxycycline, minocycline, antimalarial medications, oral tacrolimus/topical tacrolimus, sulfasalazine, interferon alpha and gamma, TNF alpha inhibitors, colchicine and PUVA therapy. As well-designed, randomized controlled trials are missing, no guidelines for the treatment of this disease can be given. Due to the small number of patients and the frequent misdiagnosis of this clinical entity, the aim of this systematic overview is to call attention to this rare condition and to help clinicians to diagnose and treat Wells syndrome effectively. Due to the good prognosis and tendency to resolve, systemic treatment should be limited to cases resistant to local therapy or with widespread lesions.

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Section: Resultsmentioning

confidence: 99%

“…Her lesions resolved after 1 month of therapy with 40 mg adalimumab per week. 43 After discontinuation, the lesions recurred and completely resolved again when the therapy was re-induced. The pathological background is the assumption that TNF alpha is released by immune cells such as eosinophils.…”

Section: Tnf Alphamentioning

confidence: 98%

Treatment of eosinophilic cellulitis (Wells syndrome) – a systematic review

Räßler

Lukács

Elsner

2016

Acad Dermatol Venereol

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“…Como ahorradores de corticoides, y en casos resistentes, se pueden administrar ciclosporina o dapsona. Otros tratamientos utilizados con anterioridad, pero sin eficacia demostrada por el escaso número de casos descritos, son azatioprina, antipalúdicos, griseofulvina, colquicina, doxiciclina, minociclina, tacrolimus oral o tópico, sulfasalazina, interferones α y γ, anti-TNF 13 , mepolizumab 2 y PUVA.…”

Section: C B Aunclassified

Síndrome de Wells con buena respuesta a la leflunomida: informe de un caso

Moneva-Leniz¹,

Snchez-Martnez²,

Gegundez-Hernndez³

et al. 2021

MCUT

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Se presenta el caso de una paciente de 56 años con celulitis eosinofílica (CE) vesículo-ampollosa que recurre tras un período asintomático de 18 años, sin desencadenante obvio, que responde al tratamiento con leflunomida, luego de la falla del tratamiento con hidroxicloroquina y metotrexato. La CE es una entidad infrecuente que puede relacionarse con neoplasias hematológicas. El tratamiento que ha mostrado ser más efectivo son los corticoides orales, pero son comunes las recaídas al suspenderlos. Se han descrito múltiples fármacos con respuestas variables como ahorradores de corticoides. Éste es el primer caso publicado de CE con respuesta favorable a la leflunomida.

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“…Кроме того, описаны отдельные случаи успешного лечения антигистаминными препаратами, миноциклином, ультрафиолетовыми лучами спектра В, ПУВА-терапией, дапсоном [30]. Имеются сообщения о хорошем эффекте адалимумаба, циклоспорина [31,32]. В качестве наружных препаратов используют наружные и внутриочаговые инъекции кортикостероидов, ингибиторы кальциневрина [30,33].…”

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Eosinophilic cellulitis (Wells syndrome): diagnostic features

Haliulin¹,

Павлов²,

Chan³

et al. 2017

Klin. dermatol. venerol.

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Синдром Уэллса (эозинофильный целлюлит Уэллса) является редким заболеванием неизвестной этиологии. Во всем мире зарегистрировано около 80 случаев. Высыпания при синдроме Уэллса похожи на целлюлит, однако инфекции не обнаруживается. Синдром Уэллса может развиться вследствие приема медикаментов, наличия различных инфекций и, вероятно, при наличии злокачественных новообразований. Несмотря на то что синдром Уэллса является спорадическим заболеванием, имеются сведения о семейных случаях. Диагноз синдрома Уэллса устанавливается на основании данных гистологического исследования. Прогноз благоприятный: кожный процесс регрессирует в течение нескольких недель или месяцев, в большинстве случаев бесследно.

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Treatment of Recalcitrant Eosinophilic Cellulitis With Adalimumab

Cited by 6 publications

References 16 publications

Treatment of eosinophilic cellulitis (Wells syndrome) – a systematic review

Treatment of eosinophilic cellulitis (Wells syndrome) – a systematic review

Síndrome de Wells con buena respuesta a la leflunomida: informe de un caso

Eosinophilic cellulitis (Wells syndrome): diagnostic features

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