Treatment of Recalcitrant Viral Warts with Combination Therapy of Systemic Acitretin and Diphenylcyclopropenone Immunotherapy

Shin, Doh Chull; Han, Sung Soo; Kim, Tae Lim; Jang, Ju Wang; Seo, Hyun-Min; Kim, Joung Soo

doi:10.5021/ad.2020.32.3.243

Cited by 4 publications

(6 citation statements)

References 12 publications

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“…22 Previous research indicates that DPCP is a successful and well-tolerated therapy for resistant common warts. 7 This is the first report to compare the effect of topical DPCP versus topical podophyllin for treating anogenital warts. We chose DPCP due to its proven efficacy on common warts, but we found no randomized trials in its use in AGWs, despite its previous success in a few case reports.…”

Section: Discussionmentioning

confidence: 98%

“…Previous research indicates that DPCP is a successful and well-tolerated therapy for resistant common warts. 7…”

Section: Discussionmentioning

confidence: 99%

“…It is often used in the treatment of recalcitrant warts. 7 Giant condyloma acuminatum of Buschke and Löwenstein, 8 melanoma, 9 alopecia areata, 10 and molluscum contagiosum. 11 Only a few case reports have shown that DPCP can successfully cure AGWs.…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness and safety of topical application of diphenylcyclopropenone versus podophyllin in treatment of genital warts

Halim

Ahmed²,

Eyada

2023

Int J STD AIDS

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Background Many therapeutic modalities are available for treating genital warts; however, the effectiveness of both diphenylcyclopropenone and podophyllin is still controversial. Aim To evaluate the effectiveness and safety of diphenylcyclopropenone and podophyllin in treating genital warts. Methods This study included 57 patients, divided randomly into two groups. Group (A): diphenylcyclopropenone ( n = 29). Group (B): podophyllin 25% ( n = 28). In group (A), sensitization was done with 2% diphenylcyclopropenone. Then, after 1 or 2 weeks, treatment started with a weekly application of diphenylcyclopropenone solutions ranging between 0.001 and 1% until clearance, or for a maximum of 10 sessions. In group (B), podophyllin 25% was applied weekly until clearance or for a maximum of 6 weeks. Results Higher clearance was achieved in group A, with 19 of 29 (65.5%) patients, than in group B, with 9 of 28 (32.1%) ( p-value = 0.004). Also, effectiveness increases with young age in group A. Shorter wart duration was associated with better response in both groups ( p-value = 0.005). No serious adverse effects occurred in either group. No recurrence was detected in group A, while seven patients (77.8%) had recurrence in group B after 1 year of follow up. Conclusion Diphenylcyclopropenone shows a higher success rate than podophyllin in treating genital warts and a lower recurrence rate.

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Section: Discussionmentioning

confidence: 98%

“…Previous research indicates that DPCP is a successful and well-tolerated therapy for resistant common warts. 7…”

Section: Discussionmentioning

confidence: 99%

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Effectiveness and safety of topical application of diphenylcyclopropenone versus podophyllin in treatment of genital warts

Halim

Ahmed²,

Eyada

2023

Int J STD AIDS

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“…21 As well, after 6 months of treatment with a conjunction of systemic acitretin and diphenylcyclopropenone (DPCP) immunotherapy, a 19-year-old man with multiple viral warts showed a significant improvement during the 12th week of therapy. 22…”

Section: Oral Retinoidmentioning

confidence: 99%

“…54 Combination of systemic treatment with the topical and intralesional treatment in several studies showed better response than monotherapy. 14,15,22,24 Systemic treatment in wart in pregnancy will be modified and scheduled according to safe tables of dermatologic medications in pregnancy and lactation. 55,56 Studies also showed high curing response in children.…”

Section: Acupuncturementioning

confidence: 99%

Systemic immunotherapy for the treatment of warts: A literature review

Mohammed

Al‐Dhubaibi

Bahaj

et al. 2022

J of Cosmetic Dermatology

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Background: Immunotherapy has emerged as a critical therapeutic tool for the treatment of warts. Immunotherapy for warts is currently restricted to recalcitrant lesions.A small number of regimens appear to be extremely effective. Furthermore, there is a scarcity of evidence-based research.Objective: Furthermore, in the majority of cases, their safety and effectiveness have not been evaluated in double-blind, controlled clinical trials, making the reproducibility of many of the listed treatments difficult to analyze and a possible placebo effect difficult to rule out.Methods: Analyzing and discussing different types of systemic immunotherapy. The different types of immunotherapy for warts are mentioned in this report. Results: Systemic immunotherapeutic modalities commonly used in the treatmentEchinacea, propolis, oral retinoids, glycyrrhizinic acid, levamisole, cimetidine, and zinc sulfate have all been reported as effective treatment modalities for different types of warts. Conclusion:Immunotherapy has emerged as one of the most important therapeutic modalities for warts. Such treatment is required not only for recalcitrant or multiple lesions, but also in the majority of treated cases.

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Principles of Topical Therapy

Buckley

2024

Rook's Textbook of Dermatology

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As well as quantifying the burden of skin disease, epidemiology provides a direct method for assessing the causes of skin diseases. Identification of causes is a necessary step in pursuing the ultimate goal of disease prevention. This chapter covers the importance of thinking in terms of population rather than individuals, and provides a summary of the substantial global morbidity caused by skin disease. Risk factors from genetics to environment are outlined, along with describing the natural history and associations of common skin diseases. Finally, there is a description of how the principles and data from epidemiological studies provide the cornerstone to planning appropriate dermatology services. The chapter closes by providing the reader with a glossary of terms and a checklist to help with reading epidemiological studies.

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Treatment of Recalcitrant Viral Warts with Combination Therapy of Systemic Acitretin and Diphenylcyclopropenone Immunotherapy

Cited by 4 publications

References 12 publications

Effectiveness and safety of topical application of diphenylcyclopropenone versus podophyllin in treatment of genital warts

Effectiveness and safety of topical application of diphenylcyclopropenone versus podophyllin in treatment of genital warts

Systemic immunotherapy for the treatment of warts: A literature review

Principles of Topical Therapy

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