Treatment of Recurrent Corneal Erosions Using Autologous Serum

Castillo, José Manuel Benítez del; Martinez-de-la-Casa, José M.; Sardiña, Ricardo Cuiña; Fernández, Rosalia Méndez; Feijoó, Julián García; Gómez, Alfredo Castillo; Rodero, Maria Matilla; Sánchez, Julián García

doi:10.1097/00003226-200211000-00010

Cited by 110 publications

(66 citation statements)

References 20 publications

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“…49 The treatment is safe with no secondary effects. 50 However, further studies are needed on larger series and with longer follow-up to determine the ideal duration of treatment and the mechanism of action.…”

Section: Autologous Serummentioning

confidence: 99%

Pathogenesis, clinical features and management of recurrent corneal erosions

Ramamurthi

Rahman

Dutton

et al. 2005

Eye

113

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Recurrent corneal erosions (RCE) are common. They are characterised by repeated episodes of pain, difficulty in opening the eyes, watering, and photophobia resulting from poor epithelial adhesion. In the majority of patients with RCE, trauma is the initiating factor. Epithelial, stromal, and endothelial corneal dystrophies have all been described in association with RCE. Other causes that may lead to RCE include chemical and thermal injuries, previous herpetic keratitis, meibomian gland dysfunction, ocular rosacea, diabetes mellitus, Salzmann's nodular degeneration, band keratopathy, previous bacterial ulceration, kerato-conjunctivitis sicca, and epidermolysis bullosa. The conditions that are associated with RCE can be either primary or secondary depending on whether the basement membrane complex abnormality is intrinsic or acquired. Primary types tend to be bilateral, symmetrical and develop in multiple corneal locations. The pathogenetic mechanism of this disorder is related to poor adhesion of the corneal epithelium to the underlying stroma. Excessive matrix metalloproteinase (MMP) activity may play a role in the pathogenesis. Although the majority of patients will respond to simple measures such as padding and antibiotic ointment, RCE resistant to simple measures require approaches that are more elaborate. The common goal of these approaches is to encourage proper formation of adhesion complexes between the epithelium and the stroma. The use of longterm contact lenses, autologous serum eye drops, botulinum toxin, induced ptosis, oral MMP inhibitors, diamond burr polishing of Bowman's membrane have been reported with varying degree of success in treating RCE. Anterior stromal puncture with insulin needles or Neodymium : aluminium-yttriumgarnet may enhance the epithelial adhesion to the basement membrane by scar formation and success rates of up to 80% have been reported in the treatment of recalcitrant RCE. Excimer laser photo-therapeutic keratectomy (PTK) is now a well-established treatment modality for RCE and is being used both safely and effectively. Partial ablation of Bowman's layer with PTK gives a smooth surface for the newly generating epithelium to migrate and form adhesion complexes. The pathogenesis, clinical features, and management options of this common disorder are discussed in this review article.

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Section: Autologous Serummentioning

confidence: 99%

Pathogenesis, clinical features and management of recurrent corneal erosions

Ramamurthi

Rahman

Dutton

et al. 2005

Eye

113

View full text Add to dashboard Cite

show abstract

“…Therefore, it may be used for the treatment of ocular surface diseases including persistent corneal epithelial defect. 8 It has been reported that the concentration of EGF is higher in tears, while that of vitamin A and TGF-β is higher in the serum. 25 Similarly, a higher concentration of substance P, NGF, and IGF-1 has been detected in the serum.…”

mentioning

confidence: 99%

“…1,[3][4][5][6][7][8] However, in regard to autologous serum, its shortcomings are that it requires repeated blood collection from patients, and that it is sometimes accompanied by discomfort or by treatment refusal by some patients. Also, it is difficult to obtain blood from patients with poor general condition or blood dyscrasia.…”

mentioning

confidence: 99%

Therapeutic Effect of Umbilical Cord Serum Eyedrops for Persistent Corneal Epithelial Defect

Yoon

Heo

Jeong

et al. 2005

Korean J Ophthalmol

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“…Del Castillo et al (23) studied the effect of 20% autologous serum in the treatment of recurrent corneal erosions in 11 eyes of 11 patients. Mean follow-up time was 9.4 ± 3.7 months (range, 4 to 16).…”

Section: Recurrent Corneal Erosionmentioning

confidence: 99%