Treatment of Recurrent Eczematous External Otitis with Honey Eardrops: A Proof‐of‐Concept Study

Henatsch, Darius; Nabuurs, Cindy H.; Goor, Rens M. van de; Wolffs, Petra; Stokroos, Robert J.

doi:10.1177/0194599817718782

Cited by 11 publications

(6 citation statements)

References 18 publications

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“…In the trial carried out by Kwakman and coworkers, the medical-grade honey did not affect colonization of the skin at central venous catheter insertion sites in intensive care units patients when applied in addition to standard disinfection with 0.5% chlorhexidine in 70% alcohol [ 49 ]. The outcomes of investigation carried out by the mentioned above group of Henatsch revealed that honey eardrops showed a strong in vitro inhibitory activity against all tested strains but did not eradicate S. aureus infection in vivo [ 50 ]. It also should be emphasized that in vivo infections are often caused by bacteria growing in the form of biofilms.…”

Section: Discussionmentioning

confidence: 99%

Study of the Anti-Staphylococcal Potential of Honeys Produced in Northern Poland

et al. 2018

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The antimicrobial activity of 144 samples of honeys including 95 products from apiaries located in Northern Poland was evaluated. The antibacterial activity of those natural products, their thermal stability, and activity in the presence of catalase was investigated by microdilution assays in titration plates. The MTT assay was performed for the determination of anti-biofilm activity. Spectrophotometric assays were used for the determination of antioxidant potential, total phenolic content, and ability to generate hydrogen peroxide. Some of the investigated honeys exhibited surprisingly high antimicrobial, especially anti-staphylococcal, potential, with Minimal Inhibitory Concentration (MIC) values of only 1.56% (v/v). Much higher resistance was observed in the case of staphylococci growing as biofilms. Lower concentrations of the product, up to 12.5% (v/v) stimulated its growth and effective eradication of biofilm required concentration of at least 25% (v/v). Hydrogen peroxide has been identified as a crucial contributor to the antimicrobial activity of honeys supplied by Polish beekeepers. However, some of the results suggest that phytochemicals, especially polyphenols, play an important role depending on botanical source (both positive, e.g., in the case of buckwheat honeys as well as negative, e.g., in the case of some rapeseed honeys) in their antimicrobial potential.

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Section: Discussionmentioning

confidence: 99%

Study of the Anti-Staphylococcal Potential of Honeys Produced in Northern Poland

et al. 2018

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“…Honey has been long appreciated for its exceptional ability to de-escalate phlogosis, hence the traditional use as a medicament on chronic inflammatory skin conditions and in the management of persistent symptoms such as unremitting discomfort, itchiness often associated with skin abrasion, and laceration due to scratching, all severely affecting the quality of patients' everyday life. Along with the conventional treatments prescribed to soothe the affected skin (predominantly topical corticosteroids), growing interest has been expressed for natural remedies in the management of disorders with a main inflammatory component such as eczematous lesions and psoriasis [103,104]. Alangari et al researched the performance of Manuka honey on atopic dermatitis (AD) patients and tried to elucidate the responsible biochemical mechanisms by AD-related in vitro models.…”

Section: Anti-inflammatory Properties Of Honeymentioning

confidence: 99%

The Rediscovery of Honey for Skin Repair: Recent Advances in Mechanisms for Honey-Mediated Wound Healing and Scaffolded Application Techniques

2021

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Honey is a honey-bee product obtained mainly by the enzymatic processing of nectar from a variety of plants, which leads to the wide range of colours and flavours available on the market. These organoleptic and nutritional features are influenced by the chemical composition, which in turn depends on the botanical origin. Bioactive compounds account for honey beneficial activity in medical applications, which explains the extensive use of honey in ethno-pharmacology since antiquity, from cough remedies to dermatological treatments. Wound healing is one of the main therapeutic uses of honey, and various design options in pharmaceutical technology such as smart delivery systems and advanced dressings are currently being developed to potentiate honey’s valuable properties for better performance and improved final outcome. In this review, we will focus on the latest research that discloses crucial factors in determining what properties are most beneficial when considering honey as a medicinal product. We will present the most recent updates on the possible mechanisms responsible for the exceptional effects of this ageless therapeutical remedy on skin repair. Furthermore, the state-of-the-art in application techniques (incorporation into scaffolds as an alternative to direct administration) used to enhance honey-mediated wound-healing properties are explored.

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“…Eczematous otitis externa is the sequel of hypersensitivity to certain organisms that are infectious or, some eardrops. It is marked by intense vexation, forming of vesicles, oozes and, crusts in the ear passage [11].…”

Section: Clinical Featuresmentioning

confidence: 99%

A Review on Otitis externa: An Approach to a Etiopathogenesis, Epidemiology, Clinical Features and Management Protocol

Gupta

Gaurkar

Gupta

2021

JPRI

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Introduction: The external ear is the part of our ears which is seen from outside. It is made up of the auricles (pinna) and external auditory canal; and, includes the outer wall of the middle ear, i.e. the eardrum. Otitis externa is a regular presentation when on call for ENT or at the emergency ENT health clinic or centre. Infective and reaction groups of otitis externa are classified. Methodology: The articles reviewed in this narrative review article have been traced from a variety of links and sources over the internet like PubMed, NCBI, ScienceDirect, NHSINFORM, Uptodate, WebmedCentral, American family physician, ClevelandClinic, StatPearls, and many more. References from high yielding sources were taken and the articles were properly assessed. Results: Paying attention to the scientific elements while performing an operative procedure can give a physician extended results. Which operative modality to be chosen depends on the patient. The patient’s choices are also important in the decision making of the operation. Discussion: External otitis is possibly spotted in almost every peer category. Approximately ten percent (10%) of humans may face this condition during their lifetime. Most of the time, the infection is mixed. Medical intervention of the ear can prove painful for most cases, therefore, post-surgery analgesics must be utilized for a time period which the treating physician prescribes. The aim of curing the patient is to free him/her from the symptoms and getting rid-off any pathogen causing a specific infection. Conclusion: The efficacy of operative modalities of extremes of otitis externa will rely on complete patient examination, history and lab results. Selection of the correct intervention, proper knowlege of the regional anatomy, paying attention to scientific elements and good post-operative care is necessary. It is never easy to avoid otitis externa, but we can make an effort to decrease the risk of developing this problem.

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Treatment of Recurrent Eczematous External Otitis with Honey Eardrops: A Proof‐of‐Concept Study

Cited by 11 publications

References 18 publications

Study of the Anti-Staphylococcal Potential of Honeys Produced in Northern Poland

Study of the Anti-Staphylococcal Potential of Honeys Produced in Northern Poland

The Rediscovery of Honey for Skin Repair: Recent Advances in Mechanisms for Honey-Mediated Wound Healing and Scaffolded Application Techniques

A Review on Otitis externa: An Approach to a Etiopathogenesis, Epidemiology, Clinical Features and Management Protocol

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