Treatment of recurrent hepatocellular carcinoma confined to the liver with repeated resection and radiofrequency ablation: A single center experience

Radiofrequency Ablation Versus Reresection in Treating Recurrent Hepatocellular Carcinoma

“…Six retrospective comparative studies 16 – 21 published from 2008 to 2014 were included in our analysis, which were all nonrandomized controlled trials (NRCTs) with low Jadad scores. Chan et al 22 conducted similar studies in 2012 and 2013.…”

“…All 6 studies 16 – 21 reported long-term OS. No statistical difference existed between the 2 comparative groups in 1-year OS (OR 0.86; 95% CI, 0.50–1.49; P = 0.587), 3-year OS (OR 0.91; 95% CI, 0.64–1.28; P = 0.581), and 5-year OS (OR 0.97; 95% CI, 0.69–1.36; P = 0.846).…”

“…Three studies 16 , 19 , 21 reported 1-, 3-, and 5-year DFS. SR is superior to RFA for 3-year DFS (OR 2.25; 95% CI, 1.37–3.68; P = 0.001) and 5-year DFS (OR 3.70; 95% CI, 1.98–6.93; P = 0.000).…”

Transarterial chemoembolization versus surgery/radiofrequency ablation for recurrent hepatocellular carcinoma with or without microvascular invasion

“…Therefore, surgery, RFA, or TACE have been considered commonly used for treatment of these patients. 13,14 Furthermore, the two treatment modalities (surgery and RFA) showed similar survival outcomes in the management of recurred HCC after hepatectomy. 26 However, patients with vascular invasion, extrahepatic metastasis, or poor liver function reserved are not eligible for surgery/RFA.…”

“…Recently, it was reported that repeated surgery for recurrent HCC can be an effective, or safe, treatment option. 13,14 However, the outcomes of different treatment modalities, such as surgery versus transarterial chemoembolization (TACE), were not compared. Another study concluded that survival outcome after repeated surgery could be superior to that of TACE in recurrent HCC patients after curative resection, 16 but this conclusion was not based on a comparison of patients with same HCC stages.…”