Treatment of recurrent unipolar major depression with captopril

Germain, L.; Chouinard, Guy

doi:10.1016/0006-3223(88)90010-8

Cited by 61 publications

(24 citation statements)

References 14 publications

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“…Previously, we demonstrated that long-term AT 1 receptor blockade is able to prevent the KA-induced depression during the light phase [15] suggesting AT 1 receptor-mediated depression-like behavior in Ang II-infused rats. The present results are in line with experimental and clinical data suggesting that angiotensin-converting enzyme inhibitors have potential antidepressant activity [36][37][38].…”

Section: Discussionsupporting

confidence: 94%

Long-term intracerebroventricular infusion of angiotensin II after kainate-induced status epilepticus: Effects on epileptogenesis, brain damage, and diurnal behavioral changes

Ivanova

Atanasova

Pechlivanova

et al. 2015

Epilepsy & Behavior

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Section: Discussionsupporting

confidence: 94%

Long-term intracerebroventricular infusion of angiotensin II after kainate-induced status epilepticus: Effects on epileptogenesis, brain damage, and diurnal behavioral changes

Ivanova

Atanasova

Pechlivanova

et al. 2015

Epilepsy & Behavior

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“…A small body of literature regarding hypertensive patients with major depression suggests that the angiotensin converting enzyme inhibitor captopril may have mood enhancing properties [182][183][184][185]. ANG II has multiple pressor actions, and blockade of its formation can reduce blood pressure.…”

Section: Hedonic and Mood-related Effects Of Sodium Deficiencymentioning

confidence: 99%

Salt craving: The psychobiology of pathogenic sodium intake

Morris

Johnson

2008

Physiology & Behavior

115

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Ionic sodium, obtained from dietary sources usually in the form of sodium chloride (NaCl, common table salt) is essential to physiological function, and in humans salt is generally regarded as highly palatable. This marriage of pleasant taste and physiological utility might appear fortunate -an appealing taste helps to ensure that such a vital substance is ingested. However, the powerful mechanisms governing sodium retention and sodium balance are unfortunately best adapted for an environment in which few humans still exist. Our physiological and behavioral means for maintaining body sodium and fluid homeostasis evolved in hot climates where sources of dietary sodium were scarce. For many reasons, contemporary diets are high in salt and daily sodium intakes are excessive. High sodium consumption can have pathological consequences. Although there are a number of obstacles to limiting salt ingestion, high sodium intake, like smoking, is a modifiable behavioral risk factor for many cardiovascular diseases. This review discusses the psychobiological mechanisms that promote and maintain excessive dietary sodium intake. Of particular importance are experiencedependent processes including the sensitization of the neural systems underlying sodium appetite and the effects of sodium balance on hedonic state and mood. Accumulating evidence suggests that plasticity within the central nervous system as a result of experience with high salt intake, sodium depletion, or a chronic unresolved sodium appetite fosters enduring changes in sodium related appetitive and consummatory behaviors.

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“…Captopril and lisinopril have been suggested as potential treatments for major depression [45,46], although only in case reports and a small, open trial. Our analysis indicated a slightly decreased frequency of symptoms of depression in people receiving these medications, but the statistical support for this was weak.…”

Section: Associations Between Specific Drug Classes and Depression Anmentioning

confidence: 99%

Anxiety and depression symptoms in arterial hypertension: the influence of antihypertensive treatment. The HUNT study, Norway

et al. 2011

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Antihypertensive drugs have been suggested to modulate symptoms of depression and anxiety. It is disputed whether this is due to the hypertension per se, its treatment, or both. The aim of this study was to investigate these associations in a large population sample. 55,472 participants in the Nord-Trøndelag Health Study (HUNT 2, 1995-1997), Norway, who completed the Hospital Anxiety and Depression rating Scale, were divided into 3 groups according to their diastolic blood pressure and antihypertensive treatment status. A cut-off of ≥90 mmHg diastolic blood pressure was used to identify hypertensive status. Differences in anxiety and depression symptom levels in untreated and treated hypertensives (all treatments) versus the normotensive reference group were explained by differences in age and gender distribution in the three groups in this study. However, the receipt of two or more antihypertensive drugs was associated with depressive symptoms alone (OR = 1.40, 95% CI = 1.03-1.90), but not with symptoms of anxiety (OR = 1.14, 95% CI = 0.83-1.57) or mixed anxiety and depression (OR = 1.19, 95% CI = 0.82-1.72) in the fully adjusted model, compared to untreated hypertension. Antihypertensive monotherapy (all agents) nor any single antihypertensive drug class were associated with symptoms of depression, anxiety, or mixed anxiety and depression. There may be a positive association between multi antihypertensive drug use and symptoms of depression, whereas this was not found in persons with symptoms of anxiety or mixed anxiety and depression. This might reflect poor antihypertensive treatment adherence leading to polypharmacy, or other unfavorable health behaviors in people with symptoms of pure depression.

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Treatment of recurrent unipolar major depression with captopril

Cited by 61 publications

References 14 publications

Long-term intracerebroventricular infusion of angiotensin II after kainate-induced status epilepticus: Effects on epileptogenesis, brain damage, and diurnal behavioral changes

Long-term intracerebroventricular infusion of angiotensin II after kainate-induced status epilepticus: Effects on epileptogenesis, brain damage, and diurnal behavioral changes

Salt craving: The psychobiology of pathogenic sodium intake

Anxiety and depression symptoms in arterial hypertension: the influence of antihypertensive treatment. The HUNT study, Norway

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