Treatment of Reflux Oesophagitis Resistant to H&lt;sub&gt;2&lt;/sub&gt;-Receptor Antagonists

Klinkenberg‐Knol, Elly C.

doi:10.1159/000200216

Cited by 25 publications

(14 citation statements)

References 15 publications

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“…Treatment strategies for GORD should aim at improving the patient’s condition at a reasonable expense and on an outpatient basis, the objective being to relieve the symptoms, improve the quality of life, and to prevent the development of GORD-related complications, such as oesophageal cancer [12]. The present medical management of GORD in the main relies on the use of long-term suppression of gastric acid secretion by using PPIs.…”

Section: Need For New Techniquesmentioning

confidence: 99%

“…However, continuous maintenance therapy with PPIs is associated with relapse rates of 33% within 2 years [12] and may require increasing doses to control reflux symptoms. The expense and the long duration of medication and the lifestyle changes which are frequently required make such medical management an unattractive option for many patients.…”

Section: Need For New Techniquesmentioning

confidence: 99%

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EndoCinch® Treatment for Gastro-Oesophageal Reflux Disease

Mahmood

Ang²

2007

Digestion

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Gastro-oesophageal reflux disease (GORD) is a common disorder which significantly impairs the quality of life. Recently an EndoCinch® system has been described, with an approach to the treatment of GORD that would obviate the need for long-term proton pump inhibitors and the cost and potential risk of laparoscopic Nissen fundoplication. We set outto evaluate the status of this new technique for the management of GORD. We review the literatures (publications and abstracts) regarding safety, efficacy, and durability of this new antireflux procedure. On the whole, this new antireflux technique produced significant improvement in GORD symptomatology and quality of life and reduced the use of antireflux medication. However, it failed to normalize acid reflux, long-term durability data are lacking, and some serious side effects have been reported. In conclusion, EndoCinch has the potential to treat patients with this common ailment. However, further studies are necessary to determine what modifications to this antireflux technique are required in order to produce the maximum clinical benefit.

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Section: Need For New Techniquesmentioning

confidence: 99%

Section: Need For New Techniquesmentioning

confidence: 99%

EndoCinch® Treatment for Gastro-Oesophageal Reflux Disease

Mahmood

Ang²

2007

Digestion

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“…However, continuous maintenance therapy with PPIs is associated with a relapse rate of 33% within 2 years [22] and may require increasing doses to control reflux symptoms. The expense and the psychological trauma of a lifetime of medication and the lifestyle changes which are frequently required make such medical management an unattractive option for many patients.…”

Section: Treatment Optionsmentioning

confidence: 99%

“…The objective being to relieve the symptoms, improve the quality of life, and to prevent the development of GORD-related complications, such as oesophageal cancer [22].…”

Section: Need For New Techniquesmentioning

confidence: 99%

Innovations in Gastro-Intestinal Endoscopy: Endoscopic Antireflux Therapies for Gastro-Oesophageal Reflux Disease

Mahmood

McMahon²,

O’Moráin³

et al. 2002

Dig Dis

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Background: Gastro-oesophageal reflux disease (GORD) is a common disorder which significantly impairs the quality of life. Recently a number of endoscopic antireflux procedures have been described, with a view to the management of GORD, thus obviating the need for long-term proton pump inhibitors and the cost and potential risk of laparoscopic Nissen fundoplication. Aim: To evaluate the status of new techniques using gastro-intestinal endoscopy for the management of GORD. Methods: Review of the literature (publications and abstracts) regarding safety, efficacy, and durability of these new antireflux procedures. Results: These antireflux techniques have produced significant improvement in GORD symptomatology and quality of life and have reduced the use of antireflux medication, without causing serious morbidity or mortality. However, the majority of these techniques have failed to adequately control oesophageal acid reflux. Conclusions: Endoscopic antireflux therapies have the potential to treat patients with GORD. However, further studies are necessary to determine what modifications to these techniques are required in order to produce the maximum clinical efficacy and durability.

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“…Continuous treatment with omeprazole results in a relapse rate of of the repositioned LES and helps to hold the lower esophagus in the abdomen. Fundoplication also increases about 30% within 1 year [60,61]. Overall 10-20% of patients will not respond to any form of treatment.…”

Section: Mechanisms For Success Of Surgerymentioning

confidence: 99%

Selection of Patients for Laparoscopic Antireflux Surgery

Glaser¹,

Wetscher²,

Klingler³

et al. 2000

Dig Dis

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Since the first laparoscopic fundoplication was performed, the frequency of antireflux surgery has increased rapidly with some centers now having an experience of about 1,000 procedures. The question arises whether this increase is due to a change in indications for the surgical treatment of gastrointestinal reflux disease (GERD) despite the simultaneous appearance of powerful antisecretory medications. Adequate knowledge of the pathophysiology of GERD is necessary in order to establish selection criteria for patients suitable for laparoscopic antireflux surgery. In this article, we review the epidemiology and pathophysiology, and provide a rationale for medical and surgical treatment. We also offer an approach to patient selection for antireflux surgery.

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Treatment of Reflux Oesophagitis Resistant to H<sub>2</sub>-Receptor Antagonists

Cited by 25 publications

References 15 publications

EndoCinch® Treatment for Gastro-Oesophageal Reflux Disease

EndoCinch® Treatment for Gastro-Oesophageal Reflux Disease

Innovations in Gastro-Intestinal Endoscopy: Endoscopic Antireflux Therapies for Gastro-Oesophageal Reflux Disease

Selection of Patients for Laparoscopic Antireflux Surgery

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