Treatment of Refractory BK Virus-Associated Nephropathy With Cidofovir

Abstract

BK virus-associated nephropathy (BKVN) has become recognized as an important cause of allograft dysfunction in renal transplant recipients and despite reduction in immunosuppression, 30-40% of recipients ultimately progress to allograft loss. Cidofovir is an antiviral agent that demonstrates in vitro activity against murine polyomavirus and has been proposed for treatment of BKVN in renal allograft recipients. We describe the clinical course, renal function, serial renal histology and urine and blood viral load measurements in two consecutive patients with refractory BKVN who were treated with low-dose cidofovir (0.25 mg/kg IV). In each case, renal dysfunction and BK viral load progressed despite reduced immunosuppression, and persistent BK virus infection was documented in serial renal allograft biopsy specimens. Administration of lowdose cidofovir was associated with clearance of BK virus DNA from blood and allograft, and stabilization of renal function in both patients, without significant toxicity. These preliminary data suggest that low-dose cidofovir may be tolerated, even among renal transplant recipients with significant renal dysfunction due to BKVN. Prospective, controlled trials are warranted to further define the optimal dose, toxicity and potential role of cidofovir in renal transplant recipients with BK virus nephropathy.

BK Virus Nephropathy in Pediatric Renal Transplant Recipients

“…Biopsy-proven rejection after immunosuppression reduction is reported in up to 25% of patients (29), which compares to 32% seen in the NAPRTCS cohort. Although there have been no controlled trials, antiviral therapy with cidofovir has been reported in cases in which immunosuppression reduction is not sufficient (13,14,30). In our study, cidofovir was used in six (24%) of 25 cases.…”

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“…Favorable outcomes have been reported in several cases. [62][63][64] Brincidofovir (CMX001) Brincidofovir (CMX001), an experimental prodrug of cidofovir, has shown antiviral efficacy and a better …”

BK Nephropathy in Renal Transplant Patients: Review

“…), hastalar yakından izlenmelidir. [58][59][60][61] Kinolonlar, DNA giraz inhibisyonu yaparak, T hücreler için BKV'ye karşı in vivo ve in vitro aktivite sağlarlar. [62][63][64] İki ay gatifloksasin kullanımı sonrası BKVN gözlenen nakilli hastalarda, viremide ve decoy hücrelerinde azalma olduğu izlenmiştir.…”