Treatment of Refractory Hypovolaemic Shock by 7.5% Sodium Chloride Injections

Defelippe, J.; Timoner, J; Velasco, I. T.; Lopes, Oswaldo Ubrı́aco; Rocha-e-Silva, Maurício; Chalon, Jack

doi:10.1097/00132586-198110000-00022

Cited by 44 publications

(57 citation statements)

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“…8 These reports stimulated hundreds of studies, including experimental and more than 60 clinical trials with 7.5% NaCl in the treatment of several conditions, such as hemorrhagic, cardiogenic, and septic shock, as well as a volume supporting solution during major surgical procedures. 9 Several groups confirmed our findings that a small volume of 7.5% NaCl, infused to animals which had lost 40 -50% of their blood volumes, rapidly restored arterial pressure, cardiac output and blood flows to vital organs.…”

Section: Review Small Volume Hypertonic Resuscitation Of Circulatory mentioning

confidence: 99%

Small Volume Hypertonic Resuscitation of Circulatory Shock

Rocha-e-Silva

Figueiredo

2005

Clinics

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Small volume hypertonic resuscitation is a relatively new conceptual approach to shock therapy. It was originally based on the idea that a relatively large blood volume expansion could be obtained by administering a relatively small volume of fluid, taking advantage of osmosis. It was soon realized that the physiological vasodilator property of hypertonicity was a useful byproduct of small volume resuscitation in that it induced reperfusion of previously ischemic territories, even though such an effect encroached upon the malefic effects of the ischemia-reperfusion process. Subsequent research disclosed a number of previously unsuspected properties of hypertonic resuscitation, amongst them the correction of endothelial and red cell edema with significant consequences in terms of capillary blood flow. A whole set of actions of hypertonicity upon the immune system are being gradually uncovered, but the full implication of these observations with regard to the clinical scenario are still under study. Small volume resuscitation for shock is in current clinical use in some parts of the world, in spite of objections raised concerning its safety under conditions of uncontrolled bleeding. These objections stem mainly from experimental studies, but there are few signs that they may be of real clinical significance. This review attempts to cover the earlier and the more recent developments in this field.

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Section: Review Small Volume Hypertonic Resuscitation Of Circulatory mentioning

confidence: 99%

Small Volume Hypertonic Resuscitation of Circulatory Shock

Rocha-e-Silva

Figueiredo

2005

Clinics

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“…продемонстрировали, что использование ГР при рефрактерном гиповолемическом шоке приводило к стабилизации гемодинамики [9].…”

Section: о б з о р ыunclassified

Use of Hypertonic Sodium Chloride Solution at Surgery under Extracorporeal Circulation

Ломиворотов¹,

Фоминский²,

Непомнящих³

2012

rmt

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“…Hypertonic solutions mobilize an amount of cellular water proportional to their osmotic load and are, therefore, reported to reduce the overall volume need in patients. The first report on the use of hypertonic 7.5% saline in patients was made by De Felippe et al, treating intensive care patients who suffered from terminal hypovolemic shock and had not responded to vigorous volume replacement and corticosteroid and dopamine infusions [7]. Hypertonic sodium chloride promptly reversed the shock in 11 of 12 patients.…”

Section: Hypertonic Crystalloidsmentioning

confidence: 99%

“…The immediate effects were a moderate rise in arterial pressure, the resumption of urine flow and recovery of consciousness tending to persist for a few hours. The volume of iso-osmotic fluid required to maintain stable circulatory condition was reduced by 90% [7].…”

Section: Hypertonic Crystalloidsmentioning

confidence: 99%

Volume replacement and microhemodynamic changes in polytrauma

Vollmar

Menger

2004

Langenbecks Arch Surg

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Though fluid administration is one of the most basic concepts in resuscitation, there is ongoing controversy and continuing research on the definition of the ideal fluid for resuscitation of trauma and hemorrhage and for intraoperative volume support. In general, crystalloids and colloids, as well as blood, blood substitutes and oxygen therapeutics, are available. This report briefly revisits the physiological mechanisms underlying resuscitation with crystalloids and colloids, emphasizing colloid-supplemented resuscitation with hypertonic saline. Finally, potential applications of oxygen therapeutics are briefly considered.

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Treatment of Refractory Hypovolaemic Shock by 7.5% Sodium Chloride Injections

Cited by 44 publications

References 0 publications

Small Volume Hypertonic Resuscitation of Circulatory Shock

Small Volume Hypertonic Resuscitation of Circulatory Shock

Use of Hypertonic Sodium Chloride Solution at Surgery under Extracorporeal Circulation

Volume replacement and microhemodynamic changes in polytrauma

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