Treatment of Refractory Immune Thrombocytopenic Purpura with an Anti-Fcγ-Receptor Antibody

Clarkson, Sarah; Bussel, James B.; Kimberly, Robert P.; Valinsky, Jay E.; Nachman, Ralph L.; Unkeless, Jay C.

doi:10.1056/nejm198605083141907

Cited by 352 publications

(140 citation statements)

References 24 publications

Supporting

Mentioning

134

Contrasting

Unclassified

Order By: Relevance

“…In contrast, blocking antibodies for the medium affinity receptor FcγRIV resulted in an impaired platelet clearance. Similar results were obtained in human ITP patients where blocking antibodies to FcγRIIIA, which is the human ortholog of murine FcγRIV [23,42], but not to human FcγRI were very efficient in blocking platelet depletion [43][44][45][46]. Thus, FcγRs are instrumental for IgG-mediated platelet depletion for murine and human ITP and are an attractive target for therapeutic intervention.…”

Section: Effector Pathways Involved In Murine Itpsupporting

confidence: 73%

The role of Fcγ receptors in murine autoimmune thrombocytopenia

et al. 2010

View full text Add to dashboard Cite

International audienceImmune thrombocytopenia (ITP) can become a life-threatening condition that requires immediate medical attention. The loss in platelet numbers during ITP can be induced by a variety of triggers. Anti-platelet antibodies of several isotypes and subclasses are a major cause for ITP and are a hallmark of many complex autoimmune diseases such as systemic lupus erythematosus. Mouse models have been important to understand the effector pathways involved in antibody-mediated platelet depletion. Therapeutic interventions based on these results have been proven successful in treating human ITP, thus validating the use of these model systems. One major problem that remains to be answered is which cell populations are crucial for platelet removal. Targeting these cells directly might be a novel therapeutic strategy and will also be important to understand the underlying biological mechanisms

show abstract

Section: Effector Pathways Involved In Murine Itpsupporting

confidence: 73%

The role of Fcγ receptors in murine autoimmune thrombocytopenia

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Such an effect on macrophage function has been correlated with an increase in platelet count in patients with autoimmune thrombocytopenia. Treatment with either Fc fragments [31], anti-Rh antibody [40] or a MoAb reacting with macrophage Fc receptor [41] produced the same effect. It has therefore been proposed that this rise in platelet count was due to the blockage of Fc receptors by pooled IgG [42].…”

Section: Discussionmentioning

confidence: 94%

The mode of action of treatment by IgG of haemolytic anaemia induced by an anti-erythrocyte monoclonal antibody

Pottier

Pierard

Barclay

et al. 1996

Clinical and Experimental Immunology

View full text Add to dashboard Cite

SUMMARYIn order to gain insight into the mechanisms by which the infusion of IgG can improve some autoimmune diseases, we induced haemolytic anaemia in mice by the injection of anti-erythrocyte MoAbs derived from NZB mice by S. Izui (Geneva). The IgG1 antibody 31-9D induces anaemia by erythrocyte sequestration in the spleen and liver, whereas the IgG2a antibody 34-3C triggers erythrophagocytosis (Shibata et al., Int Immunol 1990; 2:1133). Treatment of mice with pools of either human or mouse IgG clearly attenuated the anaemia induced by 34-3C, but not by 31-9D. Similar protection was obtained with human monoclonal IgGs from myeloma patients. Prior absorption by mouse erythrocytes did not affect the efficacy of the injected IgG. Treatment with Fc fragments also reduced the anaemia. In vitro experiments confirmed that 34-3C, but not 31-9D, triggered erythrocyte phagocytosis by murine macrophages. This process was completely inhibited by addition of polyclonal or myeloma IgG or of human Fc fragments. These results indicate that, in this model of autoimmune pathology, the protective effect of IgG is mediated by its interaction with the macrophage Fc receptors.

show abstract

“…FcγRIIb has been plays a role in nasal eosinophilia in AR (19), and FcγRIIIa gene polymorphisms play a role in the pathogenesis of ITP and atopic disease (20,21). Monoclonal antibodies against FcγRIIIa have been shown to be effective in improving thrombocytopenia in ITP (22,23). Third, elevated Th2 cytokines (IL-4, IL-10) have been observed in patients with ITP (24).…”

Section: Discussionmentioning

confidence: 99%

Association of primary immune thrombocytopenia and common allergic diseases among children

et al. 2015

View full text Add to dashboard Cite

Background:Growing evidence has revealed a link between autoimmune and allergic diseases. However, few studies have assessed the relationship between allergic diseases and primary immune thrombocytopenia (ITP), an autoimmune disease frequently occurring in children. This population-based case-control study investigated the association between common allergic diseases and the subsequent risk of developing ITP during childhood. Methods: This study investigated 1,203 children younger than 18 y of age who were diagnosed with ITP between 1998 and 2008, as well as 4,812 frequency-matched controls. The odds ratios of the association between ITP and preexisting allergic diseases were calculated. results: Children with every type of allergic disease examined in this study (except asthma) exhibited an increased risk of developing ITP; the lowest adjusted odds ratio (aOR) was 1.39 for allergic conjunctivitis (95% confidence interval (CI) = 1.09-1.79), whereas the greatest aOR was 1.84 for allergic rhinitis (95% CI = 1.49-2.27). The aORs increased with the number of concurrent allergic diseases to 2.89 (95% CI = 1.98-4.22) for children with at least three allergic diseases. conclusion: Children with atopic diathesis have a greater risk of subsequently developing ITP. The fundamental determinants of this relationship warrant further study.

show abstract

Treatment of Refractory Immune Thrombocytopenic Purpura with an Anti-Fcγ-Receptor Antibody

Cited by 352 publications

References 24 publications

The role of Fcγ receptors in murine autoimmune thrombocytopenia

The role of Fcγ receptors in murine autoimmune thrombocytopenia

The mode of action of treatment by IgG of haemolytic anaemia induced by an anti-erythrocyte monoclonal antibody

Association of primary immune thrombocytopenia and common allergic diseases among children

Contact Info

Product

Resources

About