Treatment of Relapsed or Refractory Non-Hodgkin’s Lymphoma (NHL) or Hodgkin’s Disease (HD) with High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation (HSCT) Using a Novel Mitoxantrone-Containing Preparative Regimen.
Abstract:High-dose chemotherapy with autologous HSCT is potentially curative in patients (pts) with relapsed or refractory lymphoma. However, the optimal pre-HSCT conditioning regimen is not known. Mitoxantrone, an antineoplastic agent that inhibits DNA synthesis by inhibition of topoisomerase II and by intercalation into the DNA molecule, has shown activity in several hematological malignancies, including NHL and HD. Recent evidence suggests that mitoxantrone may be more cardiotoxic than previously recognized. We eval… Show more
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