Treatment of Restless Legs Syndrome With Levodopa Plus Benserazide

Akpinar, S

doi:10.1001/archneur.1982.00510230065027

Cited by 225 publications

(102 citation statements)

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“…3,9 Another hypothesis is that the region of the motor activity is at the level of the spinal cord. 14 This is supported by several observations: (1) Dopamine containing neurons have been demonstrated in the spinal cord, 7,15,16 (2) RLS occurring after myelitis, 17 (3) by the e ective treatment with DA drugs, 12 and (4) by the appearance of abnormal movements in spinal cord injured patients. 4,18 Finally, the association of RLS with pregnancy, venous insu ciency, peripheral embolism, and relief of symptoms with vasodilators point to a vascular mechanism in some patients.…”

Section: Discussionmentioning

confidence: 81%

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Restless legs syndrome: an unusual cause for a perplexing syndrome

Glasauer

Egnatchick

1999

Spinal Cord

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Restless legs syndrome (RLS) is a well-de®ned symptom complex, occurring either as idiopathic RLS or in association with many other disorders. Although no de®nite etiology is known for this condition, several pathophysiological mechanisms have been proposed. There is supportive evidence that RLS is a central nervous system (CNS) dysfunction, suggesting involvement of the descending dopaminergic (DA) pathways, but it can also occur with spinal disorders. We present a patient su ering from RLS who eventually was diagnosed with a foramen magnum tumor. Based on the available evidence, we attempt to correlate the location of the tumor with the patient's symptoms of RLS.

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Section: Discussionmentioning

confidence: 81%

“…The latter are inhibitory in¯uences on pyramidal tract function. 12,13 Others suggest a disturbance of the inhibitory reticulospinal pathways. 3 The locus of involuntary motor activity is likely to be subcortical, possibly at the level of the peri-aqueductal gray matter of the midbrain/diencephalon region, or the pons.…”

Section: Discussionmentioning

confidence: 99%

Restless legs syndrome: an unusual cause for a perplexing syndrome

Glasauer

Egnatchick

1999

Spinal Cord

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“…The relationship between RLS and periodic limb movements (PLMS) was established in Bologna in 1962 6 . The modern RLS treatment begun in 1982, when Sevket Akpinar suggested the use of levodopa in this condition 7 . Nowadays, RLS is increasingly recognized as a very frequent condition, affecting around 6% Brazilian adults 8 .…”

Section: Brief Historymentioning

confidence: 99%

Brazilian consensus on guidelines for diagnosis and treatment for restless legs syndrome

Fröhlich

Éckeli

Bacelar³

et al. 2015

Arq. Neuro-Psiquiatr.

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“…In 1982, Akpinar [57] published his observations in 5 patients who had benefited from levodopa/benserazide. He also reported beneficial effects with bromocriptine [57]. This opened the door for a new era of therapeutic approaches to RLS.…”

Section: Dopamine Agonists For Rlsmentioning

confidence: 99%

Treatment of Restless Legs Syndrome

Comella¹

2014

Neurotherapeutics

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Restless legs syndrome (RLS) is a common disorder diagnosed by the clinical characteristics of restlessness in the legs associated often with abnormal sensations that start at rest and are improved by activity, occurring with a diurnal pattern of worsened symptoms at night and improvement in the morning. RLS is the cause of impaired quality of life in those more severely afflicted. Treatment of RLS has undergone considerable change over the last few years. Several classes of medications have demonstrated efficacy, including the dopaminergic agents and the alpha-2-delta ligands. Levodopa was the first dopaminergic agent found to be successful. However, chronic use of levodopa is frequently associated with augmentation that is defined as an earlier occurrence of symptoms frequently associated with worsening severity and sometimes spread to other body areas. The direct dopamine agonists, including ropinirole, pramipexole, and rotigotine patch, are also effective, although side effects, including daytime sleepiness, impulse control disorders, and augmentation, may limit usefulness. The alpha-2-delta ligands, including gabapentin, gabapentin enacarbil, and pregabalin, are effective for RLS without known occurrence of augmentation or impulse control disorders, although sedation and dizziness can occur. Other agents, including the opioids and clonazepam do not have sufficient evidence to recommend them as treatment for RLS, although in an individual patient, they may provide benefit.

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Treatment of Restless Legs Syndrome With Levodopa Plus Benserazide

Cited by 225 publications

References 1 publication

Restless legs syndrome: an unusual cause for a perplexing syndrome

Restless legs syndrome: an unusual cause for a perplexing syndrome

Brazilian consensus on guidelines for diagnosis and treatment for restless legs syndrome

Treatment of Restless Legs Syndrome

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