Treatment of Retinoblastoma With Argon Laser Photocoagulation

The results of this pre-clinical study suggest verteporfin may be activated in the rabbit retina with the indirect delivery system and the 690 nm laser unit (i.e., Indirect PDT). Using verteporfin, treatment effects were observed at 40-50 mW/cm in the rabbit retina, while photocoagulation was achieved at 75 mW/cm and higher power levels. Fundoscopic and histopathologic examination of treated areas showed circumscribed areas of retinal damage and a lack of generalized ocular toxicity, suggesting that this modality may represent a safe and localized method for treating intraocular retinoblastoma.

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Proton Beam Irradiation for Treatment of Experimental Human Retinoblastoma

Svitra

Budenz

Albert

et al. 1991

European Journal of Ophthalmology

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Proton beam irradiation was used to treat human retinoblastoma (Y-79 cell line) grown subcutaneously in the athymic "nude" mouse. Thirty-four tumors were included in the experimental groups, of which twenty-three were irradiated and eleven served as controls. Tumors were irradiated with protons produced at the 160 megavolts Harvard cyclotron. The dose delivered to the tumor ranged from 7.5 to 27.5 proton gray in a single treatment, and 25.0 proton gray delivered in two fractions separated by 24 hours. Reduction of tumor growth was significantly greater than controls (p less than 0.001) with treatment doses greater than or equal to 17.5 proton gray. Histologic examination revealed a marked decrease of mitotic activity in all specimens examined 48 hours after treatment at these higher doses. Total regression without evidence of remaining malignant cells was noted in three tumors treated at 17.5 proton gray or above. Our results indicate that human retinoblastoma in a murine host, with a tumor mass similar to that seen in a clinical setting, is sensitive to radiation by high energy protons.

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Treatment of Retinoblastoma With Argon Laser Photocoagulation

Cited by 4 publications

References 1 publication

Modification of an Ophthalmic Laser for Use in Sedated, Reclining Children

Modification of an Ophthalmic Laser for Use in Sedated, Reclining Children

Rabbit model of ocular indirect photodynamic therapy using a retinoblastoma xenograft

Proton Beam Irradiation for Treatment of Experimental Human Retinoblastoma

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