Treatment of Schistosome-Induced Glomerulonephritis

Immunopathology of Schistosoma mansoni infection.

“…The eluted IgG bound strongly to adult worm gut and reacted weakly with the outer tegument of the worm (195). Localization of GASP/CAA in the mesangium and capillary basement membrane of patients with membranoproliferative glomerulonephritis and end-stage renal failure indicates a role for this antigen in schistosome-specific nephropathy (211,256). Glomerular lesions affecting the mesangial areas could also be produced in heavily infected experimental animals.…”

“…Renal tissues of humans obtained by biopsy or at autopsy were examined for determining the presence of immunoglobulins, complement components, parasite antigens, and IC deposits. By direct or indirect IF, lumpy deposits of IgM, IgG, occasionally IgA and IgE, Clq, and C3 were observed in the mesangial areas and capillary walls in kidneys undergoing proliferative glomerulonephritis (11,96,129,165,188,211,252). The presence of specific antibodies was confirmed by acidic elution of homogenized renal tissue.…”

Immunopathology of Schistosoma mansoni infection

“…Antigen M was found in the blood, milk, and urine of infected patients and hamsters (58)(59)(60)249) and appears to be related to CCA (201); its occurrence also correlates with the intensity of infection. Demonstration of soluble egg antigens (SEA) in kidney extracts from infected baboons (167) but not mice (121) and of parasite deoxyribonucleic acid in the glomeruli of hamsters (160) (211,256). Glomerular lesions affecting the mesangial areas could also be produced in heavily infected experimental animals.…”