Treatment of sebaceous cysts in keloids: Ultrapulse mode‐fractionated carbon dioxide lasers combined with injection of low‐concentration triamcinolone acetonide and 5‐fluorouracil

Liu, Yue; Su, Xueshang; Hu, Jintian; Zhan, Sien; Wang, Meng; Wang, Lianzhao

doi:10.1111/jocd.14593

Cited by 3 publications

(4 citation statements)

References 7 publications

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“…For keloid, which is already soft but still red, that is, the III stage in this study, the treatment should focus on inhibiting vascular dysplasia and dilatation. According to the treatment experience of our team, for keloids initially entering a flat and soft state, if the injection of TAC + FU is suddenly replaced by a single injection of a lower concentration of FU, the recurrence rate can be as high as 90% 8,9 . Although increasing the concentration of FU injection can reduce the recurrence rate to a certain extent, it will also increase the risk of ulceration and necrotic scab in the injection area, and there is no much benefit after weighing the pros and cons.…”

Section: Discussionmentioning

confidence: 99%

“…According to the treatment experience of our team, for keloids initially entering a flat and soft state, if the injection of TAC + FU is suddenly replaced by a single injection of a lower concentration of FU, the recurrence rate can be as high as 90%. 8,9 Although increasing the concentration of FU injection can reduce the recurrence rate to a certain extent, it will also increase the risk of ulceration and necrotic scab in the injection area, and there is no much benefit after weighing the pros and cons. Therefore, in this study, it is possible to proceed from Stage I to Stage III treatment, that is, keloids receiving a single FU injection need to receive local electron irradiation (Stage II treatment) beforehand.…”

Section: F I G U R E 2 (A)mentioning

confidence: 99%

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A modified nonsurgical treatment of keloids: Cocktail therapy

Liu

Cao

et al. 2023

J of Cosmetic Dermatology

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BackgroundThe high recurrence rate after nonsurgical treatment of keloid is a major challenge for clinicians. Although there are many existing treatment options, how to optimize and upgrade the existing options and make a reasonable combination of utilization is our concern. The aim of this study is to provide a comprehensive non‐surgical treatment for keloid—cocktail therapy.MethodsAccording to the different changes of keloid with treatment, the treatment was divided into four stages, and different treatment schemes were adopted for each stage. The incidence of side effects of keloid at each stage and the effective rate and cure rate 16 months after the end of treatment were analyzed.ResultsAll patients completed this study on time, and were followed up 16 months after the end of treatment, the treatment effective rate was 100%, and the cure rate was up to 92.8%.ConclusionCocktail therapy can achieve a higher cure rate of keloid, and is worthy of clinical promotion.

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Section: Discussionmentioning

confidence: 99%

Section: F I G U R E 2 (A)mentioning

confidence: 99%

A modified nonsurgical treatment of keloids: Cocktail therapy

Liu

Cao

et al. 2023

J of Cosmetic Dermatology

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“…Laser therapy for both ECs and keloid tissue, combined with or without ILCs therapy, can be considered for patients with surgical contraindications after excluding focal infection. In addition, Liu and colleagues 22 reported the effectiveness of ultrapulse mode-fractionated carbon dioxide lasers combined with intralesional injection of low-concentration TAC and 5-fluorouracil in treating the coexistence of ECs and keloids, with minimal irritation to keloids.…”

Section: Discussionmentioning

confidence: 99%

Effect of Epidermoid Cysts on the Efficacy of Intralesional Corticosteroid Therapy for Hypertrophic Scars and Keloids: A Prospective Pilot Study

Xu,

Bao,

Liu

et al. 2023

Dermatol Surg

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BACKGROUND Patients with hypertrophic scars (HSs) or keloids occasionally have epidermoid cysts (ECs), and the effect of ECs on the effectiveness of intralesional corticosteroids (ILCs) treatment in these patients has not been reported. OBJECTIVE This study aims to evaluate the influence of ECs on the outcomes of ILCs treatment in patients with HSs or keloids. MATERIALS AND METHODS This prospective study included 572 patients with keloids (n = 461) or HSs (n = 111). Patients received intralesional triamcinolone acetonide injection (0.05 mL/injection) at a concentration of 40 mg/mL and every 28 days for 4 sessions, with a 1-year follow-up. RESULTS A higher incidence of ECs was observed in keloid patients (16.92%) compared with HSs patients (7.21%). Keloid patients with ECs were older (p = .008) and had a longer disease duration (p = .0148), higher Vancouver scar scale (VSS) scores (p = .04), and greater thickness (p = .006). Keloid patients with ECs showed less improvement in VSS scores (p < .0001) and thickness (p < .0001) after ILCs treatment, with a higher recurrence rate (p < .0001). The overall complication rate in keloid patients with ECs after ILCs treatment was 49.51%. CONCLUSION Epidermoid cysts under keloids were associated with a poor response to ILCs therapy. Therefore, it is recommended to incorporate ultrasonography as a routine examination for keloid patients to aid in better decision making in clinical practice.

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“…Its pharmacological mechanism is to inhibit the phagocytosis of antigens by macrophages, inhibit the transformation of beta (β) cells into plasma cells and achieve the purpose of immunity by interfering with body fluids; it also inhibits the growth of white blood cells and macrophages in the periphery of blood vessels and reduces the incidence of inflammation. The content of α-globulin collagenase inhibitor decreases rapidly and a large number of collagenase synthesis occurs, thereby promoting the decomposition between fibers, achieving flattening of the skin surface, thinning of the epidermis and reducing the gaps between collagen fibers [7] . The use of triamcinolone acetonide injection is strictly regulated because when the concentration is too low, the curative effect is poor and when the concentration is too high, it is easy to accumulate in the skin and cause adverse reactions such as pigmentation decline and ulceration.…”

Section: Scorementioning

confidence: 99%

Evaluation of Adverse Reactions and Effects of Triamcinolone Acetonide Combined with Compound Betamethasone in Keloid

Zhang¹,

Shen²,

Zeng³

2023

IJPS

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Effects of Triamcinolone Acetonide Combined with Compound Betamethasone in KeloidTo explore the drug effect and adverse reaction of triamcinolone acetonide combined with compound betamethasone in keloid is the objective of the study. 100 patients were randomly divided into study group and control group (50 patients in each group). The research group received sequential treatment with triamcinolone acetonide injection combined with compound betamethasone injection and the control group received compound betamethasone injection. Both groups had 3 courses of treatment and each course of treatment lasted for 3 w. The Vancouver scar scale score, treatment effect and adverse reactions were compared between the two groups and the recurrence rate was followed up for 1 y after the end of medication. Before treatment, there was no significant difference in Vancouver scar scale scores between the two groups but after medication, the study group was better than that of the control group (p<0.05). The total effective rate of the study group (82 %) was higher than that of the control group (54 %, p<0.05). The total incidence of adverse drug reactions in the study group was 8 % while in the control group it was 6 % and the comparison between the two groups was not statistically significant. The recurrence rates of the study group and the control group were 28 % and 34 % 6 mo after the end of medication and 32 % and 42 % after 12 mo. There was a significant difference between the two groups. The sequential injection of triamcinolone acetonide combined with compound betamethasone is effective in the treatment of keloids, with high safety and low recurrence rate, which is worthy of clinical recommendation.

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Treatment of sebaceous cysts in keloids: Ultrapulse mode‐fractionated carbon dioxide lasers combined with injection of low‐concentration triamcinolone acetonide and 5‐fluorouracil

Cited by 3 publications

References 7 publications

A modified nonsurgical treatment of keloids: Cocktail therapy

A modified nonsurgical treatment of keloids: Cocktail therapy

Effect of Epidermoid Cysts on the Efficacy of Intralesional Corticosteroid Therapy for Hypertrophic Scars and Keloids: A Prospective Pilot Study

Evaluation of Adverse Reactions and Effects of Triamcinolone Acetonide Combined with Compound Betamethasone in Keloid

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