Treatment of Severe Drug Overdosage With Charcoal Hemoperfusion

Mc, Gelfand; Jf, Winchester; Jh, Knepshield; Km, Hanson; Sl, Cohan; Bs, Strauch; Kl, Geoly; Ac, Kennedy; Ge, Schreiner

doi:10.1097/00002480-197700230-00160

Cited by 68 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If these comatous patients do not respond to intensive supportive care with repeated charcoal thera py, hemodialysis or hemoperfusion should be considered. Using charcoal particles coated with an acrylic hydrogel polymer, Gelfand et al achieved a phénobarbital removal rate of 640 mg/h [7], With our present technique, a removal rate for phénobarbital as high as 592 mg/h can be obtained! Our preliminary clinical experiences have shown that although all our critically poisoned patients were hemodynamically unstable, CAVHP went smoothly, and relevant amounts of the drugs could be removed.…”

Section: Discussionmentioning

confidence: 66%

Continuous Arteriovenous Hemoperfusion in Acute Poisoning

Lin

Lim²

1994

Blood Purif

View full text Add to dashboard Cite

We have investigated the efficacy of a pumpless hemoperfusion technique, continuous arteriovenous hemoperfusion (CAVHP) in 3 cases of acute intoxications with meprobamate, theophylline and phenobarbital. Dramatic responses were noted in both hemodynamic unstable and comatous patients. With this technique, a blood flow of 120cm³/ min could be achieved in severe hypotension. Moreover, with the restoration of blood pressure, blood flow increased to 150-400 cm³/ min. Our preliminary experience has shown that CAVHP allows an exceptionally high solute elimination. Hemoperfusion clearances of meprobamate, phenobarbital and theophylline were 198 ± 5.6 cm³/min, 290.25 ± 25.33 cm³/ min and 192.79 ± 55 cm³/ min, respectively. Our present results suggest that CAVHP is a simple, safe, effective and less costly alterative of conventional hemoperfusion.

show abstract

Section: Discussionmentioning

confidence: 66%

Continuous Arteriovenous Hemoperfusion in Acute Poisoning

Lin

Lim²

1994

Blood Purif

View full text Add to dashboard Cite

show abstract

“…These will be discussed in more detail in a later section of this chapter. The results of these clinical trials have led to the routine use of this approach around the world for the treatment of drug poisoning (Better et al, 1979;Biberstein et al, 1983;Cohan et al, 1982;Verpooten et al, 1984;Gelfand et al, 1977;Gibson et al, 1978;Lorch and Garella, 1979;Winchester, 1996;Diaz-Buxo et al, 1978;Sideman and Chang, 1980b;Piskin and Chang, 1982;Chang and Zheng, 1983;Chang and Ho, 1985;Chang and Nicolaev, 1987;Chang and Odaka, 1991;Klinmann et al, 1990;Kawasaki, 2000;Lin et al, 2002;Lopez-Lago et al, 2002;Peng et al, 2004;Chinese Symposium on Hemoperfusion, 2005, also chapters in this book). The exact method of preparing artificial cells containing adsorbent has been published in reproducible detail for all to use (Chang, 1972a.…”

Section: Treatment Of Patients With Severe Accidental or Suicidal Poimentioning

confidence: 99%

First Design and Clinical Use in Patients of Surface Modified Sorbent Hemoperfusion Based on Artificial Cells for Poisoning, Kidney Failure, Liver Failure and Immunology

Chang¹

2017

Hemoperfusion, Plasmaperfusion and Other Clinical Uses of General, Biospecific, Immuno and Leucocyte Adsorbents

View full text Add to dashboard Cite

“…Previously, standard haemodialysis was limited to removal of low molecular weight, water-soluble drugs such as lithium and methanol. Intoxication with protein-bound drugs such as theophylline, phenobarbitone and carbamazepine generally required treatment with activated charcoal haemoperfusion 53,54 . However, haemoperfusion is associated with adverse effects such as thrombocytopenia, leucopenia and hypocalcaemia.…”

Section: Blood Purification In Toxicologymentioning

confidence: 99%

An Introduction to Extracorporeal Blood Purification in Critical Illness

Lim

Tan

2012

Proceedings of Singapore Healthcare

View full text Add to dashboard Cite

Critical care nephrology is an emerging sub-specialty with rapid technological advancement and a growing body of dedicated literature in blood purification techniques. Their applications have been extended to improve morbidity and survival in multiple organ dysfunctions. Novel techniques have also allowed us to push the frontiers in transplant medicine, giving high-immunological risk patients a chance at a kidney transplant where this was previously precluded by hyperacute antibody-mediated rejection. We aim to review the myriad extracorporeal blood purification techniques now available for treating various critical illnesses in our clinical practice. Some of these techniques will still require further clinical research to determine the optimal timing and dose in order to achieve significant improvement in clinical outcomes.

show abstract

Treatment of Severe Drug Overdosage With Charcoal Hemoperfusion

Cited by 68 publications

References 0 publications

Continuous Arteriovenous Hemoperfusion in Acute Poisoning

Continuous Arteriovenous Hemoperfusion in Acute Poisoning

First Design and Clinical Use in Patients of Surface Modified Sorbent Hemoperfusion Based on Artificial Cells for Poisoning, Kidney Failure, Liver Failure and Immunology

An Introduction to Extracorporeal Blood Purification in Critical Illness

Contact Info

Product

Resources

About