Treatment of severe oral mucositis in a pediatric patient undergoing chemotherapy

Ribeiro, Isabella Lima Arrais; Valença, Ana Maria Gondim; Bonan, Paulo Rogério Ferreti

doi:10.1590/1981-863720150003000143007

Cited by 8 publications

(12 citation statements)

References 20 publications

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“…In the present study, an increase in the platelet count above the reference level was identified as a risk factor for the occurrence of SOM. This finding is controversial in the literature because, according to some reports, the occurrence of oral mucositis is associated with thrombocytopenia [7,20,21]. A possible explanation for this discrepancy is that some patients with thrombocytopenia received platelet concentrate transfusions to help them recover a normal platelet count.…”

Section: Discussionmentioning

confidence: 99%

Severe Oral Mucositis in Pediatric Cancer Patients: Survival Analysis and Predictive Factors

Damascena

Lucena

Ribeiro

et al. 2020

IJERPH

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This paper investigates the occurrence of severe oral mucositis and associated factors in blood and solid cancer pediatric patients subjected to cancer treatment, using a survival analysis. A longitudinal, descriptive, observational and inductive study of 142 pediatric patients aged from 0 to 19 years was conducted from 2013 to 2017. Data were collected using a form to record the sociodemographic characteristics and health-related aspects of patients and the modified Oral Assessment Guide (OAG). Survival analysis was performed using the Kaplan–Meier method and Cox semiparametric model. The median times to occurrence of severe oral mucositis were 35.3 and 77.1 days for patients with hematologic malignancies and solid tumors, respectively. The Cox model showed that white cell changes and platelet counts as well as the use of natural chemotherapeutic agents are risk factors for the occurrence of oral mucositis among patients with hematologic malignancies. Nonetheless, among patients with solid tumors, the occurrence of oral mucositis was associated with female sex, mixed ethnicity, the presence of metastasis, abnormal creatinine levels, a combination of chemotherapy, radiotherapy, and surgery, and the administration of chemotherapeutic agents included in the miscellaneous group. The time to occurrence of severe oral mucositis and its associated factors varied according to cancer type.

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Section: Discussionmentioning

confidence: 99%

Severe Oral Mucositis in Pediatric Cancer Patients: Survival Analysis and Predictive Factors

Damascena

Lucena

Ribeiro

et al. 2020

IJERPH

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“…O protocolo de tratamento para as lesões de mucosite oral grave utilizado no setor de pediatria do Hospital Napoleão Laureano inclui a utilização diária (4x/dia) de bochecho com 10ml de uma solução para mucosite formulada com: Soro Fisiológico, Nistatina, Decadron, Difenidramina, Morfina, Lidocaína 2% e Complexo B, manipulada no próprio hospital, diariamente e a aplicação de laser de baixa potência calibrado para um comprimento de onda de 670nm, uma potência de 40-60mW e uma dose de 4J/cm 2 , aplicada de forma pontual por 30 segundos nas regiões avermelhadas e ulceradas com ou sem pseudomembrana 13 .…”

Section: Discussionunclassified

Associação terapêutica no manejo da mucosite oral quimioinduzida em pacientes pediátricos

Costa¹,

Limeira²,

Carvalho³

et al. 2018

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O objetivo deste trabalho foi discutir casos de mucosite oral grave quimioinduzida, tratados com solução oral para bochecho associado a laseterapia de baixa potência em pacientes pediátricos oncológicos. As patologias apresentadas pelos pacientes que apresentaram a mucosite foram: Leucemia Linfoblástica Aguda (LLA), Osteossarcoma e Tumor de Wilms. As lesões se apresentaram nos seguintes sítios anatômicos: vermelhão do lábio, mucosa labial, e língua. O tempo médio para regressão das lesões foi de 6,8 ± 3,9 dias. O protocolo de tratamento consistiu na utilização da solução para mucosite oral utilizada no Hospital Napoleão Laureano, João Pessoa/PB. Concomitante ao uso da solução oral, iniciou-se a terapia fotodinâmica com laser de baixa potência (ECCO Fibras e Dispositivos; n/s–040401; modelo–BM0004A), calibrado para um comprimento de onda de 670 nm, potência de 40mW e densidade de energia de 4 J/cm2. Todos os pacientes tiveram remissão das lesões de mucosite oral em até 14 dias após o início da intervenção terapêutica. Concluiu-se que o protocolo utilizado, com o uso da laserterapia de baixa potência aliado à solução de mucosite oral mostrou-se eficaz no tratamento da mucosite oral em pacientes pediátricos em tratamento antineoplásico.

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“…16 Pro-inflammatory cytokines such as TNF and IL-1β are expressed within the oral mucosa in patients developing mucositis after receiving radiotherapy for head and neck cancer. 20 Two studies by Bossi et al from Milan, Italy, and Curra et al from Brazil found a significant correlation between oral mucositis and TNF-α. The contradictory results of the aforementioned studies from our studies are probably due to the larger involvement of healthy volunteers, other types of malignancy, sample size, and enrollment of the control group.…”

Section: Stage Of Mucositismentioning

confidence: 97%

Evaluation of oral mucositis in pediatric cancer patients in Hiwa Hospital in Sulaymaniyah city, Kurdistan Region, Iraq

Abdullah¹,

Mohammad²,

Rawi

et al. 2021

Zanco J. Med. Sci.

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Background and objective: Oral mucositis is caused by the destruction of the oral mucosal epithelium and suppression of its growth secondary to antineoplastic treatment in the form of chemotherapeutic drugs, substances, or radiotherapy. This study aimed to evaluate oral mucositis in pediatric cancer patients because it is one of the common side effects of cancer therapy that influences the outcome. Methods: This is a cross-sectional study that enrolled 100 pediatric patients with both hematological and non-hematological cancer. The age of the patients ranged from 1-18 years, involving both genders. Cases admitted to Hiwa hospital were clinically evaluated for oral mucositis, and ethical permission was taken from parents. Risk factors were assessed, including age, sex, cancer type, type of chemotherapy, radiotherapy, number of cycles, complete blood count, interleukin-1 beta, interleukin-6, tumor necrosis factor-alpha, and tumor necrosis factor-beta. Results: Baseline serum cytokines levels showed significant correlation between Interleukin-6 and intensity of the oral mucositis (P = 0.003, rho = 0.314) and no correlation between severity of oral mucositis with tumor necrosis factor-alpha, tumor necrosis factor-beta nor interleukin-1 beta (P = 0.140 and rho = 0.258, P = 0.463 and rho = -0.079, and P = 0.706 and rho = -0.041, respectively). There was significant relationship between Hemoglobin level, neutropenia and type of non-hematological cancer with the intensity of oral mucositis respectively (P ≤0.001 and rho = -0.352, P = 0.027 and rho = -0.221, and P = 0.035 and rho = 0.095, respectively). Correlation between age, gender, white blood cell count, platelet count, type of hematological malignancy and past history with the intensity of the oral mucositis did not show significant result. Conclusion: Intensity of oral mucositis increased with anemia, neutropenia, high interleukin-6 level, and the type of non-hematological cancer. It is recommended to treat anemic, neutropenic patients as soon as possible before exacerbating the mucositis. Methotrexate is the most aggressive drug alone and in combined chemotherapy agents, which may cause mucositis and needs prophylaxis like topical nystatin suspension or other methods. Keywords: Oral mucositis; Pediatric cancer; Non-hematological; Hematological; Sulaymaniyah.

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Treatment of severe oral mucositis in a pediatric patient undergoing chemotherapy

Abstract: ABSTRACT

Cited by 8 publications

References 20 publications

Severe Oral Mucositis in Pediatric Cancer Patients: Survival Analysis and Predictive Factors

Severe Oral Mucositis in Pediatric Cancer Patients: Survival Analysis and Predictive Factors

Associação terapêutica no manejo da mucosite oral quimioinduzida em pacientes pediátricos

Evaluation of oral mucositis in pediatric cancer patients in Hiwa Hospital in Sulaymaniyah city, Kurdistan Region, Iraq

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