Treatment of Sickle Cell Disease in Sub-Saharan Africa: We have come a long way, but still have far to go

Akinsete, Annette

doi:10.51496/jogm.v2.79

Cited by 3 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…health resources and weak healthcare systems impede individuals' access to adequate healthcare. [4][5][6][7] SCD is intricately associated with a broad spectrum of acute complications, including painful crises, splenic sequestration and acute chest syndrome, alongside chronic complications such as chronic anaemia, SCD nephropathy, pulmonary hypertension and avascular necrosis of the femoral head. 8 9 Typically, SCD-related complications manifest from infancy, persisting across the life course and potentially impacting multiple organs.…”

Section: Open Accessmentioning

confidence: 99%

“…The Global Burden of Disease study of 2021 ranked SCD as the 12th leading cause of mortality 3. Despite its pervasive distribution, SCD’s impact is particularly severe in developing countries, notably in sub-Saharan Africa, the Middle East and parts of India, where constrained health resources and weak healthcare systems impede individuals’ access to adequate healthcare 4–7…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Self-management needs, strategies and support for sickle cell disease in developing countries: a scoping review protocol

Druye,

Boso,

Amoadu

et al. 2024

BMJ Open

View full text Add to dashboard Cite

IntroductionSickle cell disease (SCD) poses a significant global health burden, particularly affecting individuals in developing countries with constrained healthcare resources. While research on self-management in the context of SCD is emerging, it has predominantly focused on primary studies, and there is a notable dearth of evidence synthesis on SCD self-management in developing countries. This scoping review aims to identify and map self-management needs of individuals living with SCD, the strategies they employed to meet those needs, and the support systems available to them.Methods and analysisThe review will be conducted following the Arksey and O’Malley’s (2005) 29 framework to comprehensively examine the landscape of SCD self-management research. Searches will be performed in PubMed, Scopus, Embase and Dimensions AI, with additional searches in other databases and grey literature. Indexed literature published in English from inception to January 2024 will be included. Reference list from included studies will also be searched manually. Two teams will be constituted to independently screen titles, abstracts and full text against the eligible criteria. Data will be extracted from included studies onto a customised data extraction form.Ethics and disseminationEthical approval is not required for this review due to the fact that it synthesises information from available publications. The findings will be disseminated through publication in a peer-reviewed journal. Also, the findings will possibly be presented at relevant international and national conferences. This protocol has already been registered with the Open Science Framework. The study characteristics such as design and setting will be descriptively analysed and presented as graphs, tables and figures. Thematic analysis will also be conducted based on the study objectives and presented as a narrative summary.

show abstract

Section: Open Accessmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Self-management needs, strategies and support for sickle cell disease in developing countries: a scoping review protocol

Druye,

Boso,

Amoadu

et al. 2024

BMJ Open

View full text Add to dashboard Cite

show abstract

Self-management needs, strategies and support for individuals with sickle cell disease in developing countries: a scoping review

Druye,

Amoadu,

Boso

et al. 2024

BMJ Open

View full text Add to dashboard Cite

IntroductionSickle cell disease (SCD) poses a significant global health burden, particularly affecting individuals in developing countries with constrained healthcare resources. While research on self-management in the context of SCD is emerging, it has predominantly focused on primary studies. The aim of the scoping review was to identify and map self-management needs of individuals living with SCD, the strategies they employed to meet those needs, and the support interventions available to them.Methods and analysisThe review was conducted following the Askey and O’Malley’s framework to examine the landscape of SCD self-management research. Searches were conducted in PubMed, Scopus, Embase and Dimensions AI, with additional searches in other databases from inception to June 2024 included. Evidence from 14 studies was synthesised to identify self-management needs, strategies and interventions for individuals with SCD.ResultsThe review identified diverse self-management needs among individuals with SCD, including knowledge deficits, emotional challenges, physical limitations and barriers to healthcare access. Various self-management strategies were reported, such as nutritional management, psychological coping techniques and proactive healthcare management. Self-management interventions, predominantly delivered by healthcare professionals, focused on providing education, skills training and support to individuals with SCD. The outcomes of self-management interventions consistently demonstrated significant improvements across various dimensions, including self-efficacy, knowledge enhancement, self-care practices and psychological well-being among individuals with SCD.ConclusionThis scoping review underscores the importance of addressing the diverse self-management needs of individuals with SCD through tailored interventions and support systems to enhance overall well-being and disease management. Healthcare professionals should prioritise the implementation of multidisciplinary self-management interventions that encompass medical, emotional and social aspects of care to effectively support individuals with SCD in managing their condition. Future research should focus on longitudinal studies to assess the long-term effectiveness of self-management interventions in improving patient outcomes.

show abstract

Evolving Landscape of Sickle Cell Anemia Management in Africa: A Critical Review

Musuka,

Iradukunda,

Mano

et al. 2024

TropicalMed

View full text Add to dashboard Cite

Sickle cell disease (SCD) is a prevalent inherited blood disorder, particularly affecting populations in Africa. This review examined the disease’s burden, its diverse clinical presentations, and the challenges associated with its management in African settings. Africa bears a significant burden of SCD, with prevalence varying across countries and age groups. Newborn screening programs have highlighted the high prevalence of SCD at birth, emphasizing the need for early diagnosis and intervention. The clinical manifestations of SCD in Africa are multifaceted, encompassing acute complications like vaso-occlusive crises, acute chest syndrome, and stroke, as well as chronic complications such as organ damage and leg ulcers. Biological factors, including fetal hemoglobin levels, and demographic factors, like age and sex, influence disease severity and outcomes. The management of SCD in Africa faces numerous challenges. Limited access to resources, including diagnostic tools, medications, and trained healthcare professionals, hinders optimal care. The high cost of advanced therapies further restricts patient access. Cultural stigma and a lack of awareness create additional barriers to effective management. To address these challenges, early diagnosis through newborn screening programs and point-of-care testing is crucial. Comprehensive care models, including hydroxyurea therapy, pain management, and patient education, are essential for improving outcomes. Collaboration with international networks and leveraging local resources can enhance the sustainability of SCD programs. In conclusion, SCD significantly impacts African populations. Overcoming the challenges associated with its management requires addressing resource limitations, affordability issues, and cultural barriers. Early diagnosis, comprehensive care models, and ongoing research focused on affordability and accessibility are crucial for improving the lives of individuals living with SCD in Africa.

show abstract

Treatment of Sickle Cell Disease in Sub-Saharan Africa: We have come a long way, but still have far to go

Cited by 3 publications

References 14 publications

Self-management needs, strategies and support for sickle cell disease in developing countries: a scoping review protocol

Self-management needs, strategies and support for sickle cell disease in developing countries: a scoping review protocol

Self-management needs, strategies and support for individuals with sickle cell disease in developing countries: a scoping review

Evolving Landscape of Sickle Cell Anemia Management in Africa: A Critical Review

Contact Info

Product

Resources

About