Treatment of single gingival recessions using biofunctionalized collagen matrix: A case series

Abstract

BackgroundConnective tissue graft substitutes have been used widely to overcome autogenous graft limitations. Nevertheless, they do not provide comparable results in the treatment of periodontal and peri‐implant soft tissue defects. Based on the principles of tissue‐engineered materials, injectable platelet‐rich fibrin (i‐PRF) has been combined with collagen matrices (CMs) to enhance their clinical efficacy. To the best of our knowledge, this is the first case series demonstrating the use of i‐PRF for the biofunctionalization of a volume‐stable collagen matrix (VCMX) as an adjunct to coronally advanced flap (CAF) to treat single gingival recession (GR) defects.Methods & ResultsThe study included 10 patients. Bleeding on probing, probing depth, GR height, clinical attachment level, esthetics, and dentin hypersensitivity were evaluated. After 6 months, a significant GR reduction (RecRed: 2.15 ± 0.7 mm; p = 0.005) and percentage of root coverage (% RC) of 81.13% were observed. Additionally, 40% of the sites showed complete root coverage. Gingival thickness increased 0.64 mm. Patient‐centered evaluations demonstrated dentin hypersensitivity and esthetics improvements by the end of follow‐up.ConclusionVCMX biofunctionalized with i‐PRF associated with CAF technique showed promising clinical outcomes in the treatment of single RT1 GR defects.

Platelet-rich fibrin for rehydration and pre-vascularization of an acellular, collagen membrane of porcine origin

“…Furthermore, a short observation period was chosen since the focus was the early interaction. So far, multiple other groups have shown the described pro-angiogenic effects in the clinical setting [ 44 – 46 ]. The presented pre-clinical supplementary data should support clinicians in day-to-day decisions in dentoalveolar surgery.…”