Treatment of sinonasal undifferentiated carcinoma with neoadjuvant chemotherapy and proton therapy

Thekkedath, Eby; Mikulic, Sebastian; Kandah, Fadi; Sheffield, Sandra

doi:10.1016/j.cpccr.2020.100032

Cited by 2 publications

(3 citation statements)

References 8 publications

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“…As an example of a specific successful case, Thekkedath et al reported the case of a 31-year-old Bosnian male who presented with headaches, facial pain, and epistaxis who was found to have a very large SNUC. The patient experienced near complete resolution of his stage IVB (T4b N0 M0) SNUC after treatment with combination chemotherapy (cisplatin and gemcitabine followed by weekly cisplatin) in combination with proton therapy [31]. This illustrates the potential of proton beam therapy, however SNUC is a difficult cancer to conquer and refinements in dose delivery will help ensure similar outcomes in a larger fraction of cases.…”

Section: Discussionmentioning

confidence: 85%

A Comparison of Proton Stopping Power Measured with Proton CT and x-ray CT in Fresh Post-Mortem Porcine Structures

DeJongh,

Rykalin

et al. 2020

Preprint

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Currently, calculations of proton range in proton therapy patients are based on a conversion of CT Hounsfield Units of patient tissues to proton relative stopping power. Uncertainties in this conversion necessitate larger proximal and distal planned target volume margins. Proton CT can potentially reduce these uncertainties by directly measuring proton stopping power. We have used a prototype proton imaging system to acquire proton radiography and proton CT images of a sample of pork

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Section: Discussionmentioning

confidence: 85%

A Comparison of Proton Stopping Power Measured with Proton CT and x-ray CT in Fresh Post-Mortem Porcine Structures

DeJongh,

Rykalin

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…reported the case of a 31‐year‐old Bosnian male who presented with headaches, facial pain, and epistaxis who was found to have a very large SNUC. The patient experienced near complete resolution of his stage IVB (T4b N0 M0) SNUC after treatment with combination chemotherapy (cisplatin and gemcitabine followed by weekly cisplatin) in combination with proton therapy 33 . SNUC is a difficult cancer to conquer, and this case illustrates the potential of proton beam therapy.…”

Section: Discussionmentioning

confidence: 91%

“…The patient experienced near complete resolution of his stage IVB (T4b N0 M0) SNUC after treatment with combination chemotherapy (cisplatin and gemcitabine followed by weekly cisplatin) in combination with proton therapy. 33 SNUC is a difficult cancer to conquer, and this case illustrates the potential of proton beam therapy.Refinements in dose delivery will help ensure similar outcomes in a larger fraction of cases.…”

Section: Discussionmentioning

confidence: 96%

A comparison of proton stopping power measured with proton CT and x‐ray CT in fresh postmortem porcine structures

DeJongh

Rykalin

et al. 2021

Medical Physics

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Purpose: Currently, calculations of proton range in proton therapy patients are based on a conversion of CT Hounsfield units of patient tissues into proton relative stopping power. Uncertainties in this conversion necessitate larger proximal and distal planned target volume margins. Proton CT can potentially reduce these uncertainties by directly measuring proton stopping power. We aim to demonstrate proton CT imaging with complex porcine samples, to analyze in detail three-dimensional regions of interest, and to compare proton stopping powers directly measured by proton CT to those determined from x-ray CT scans. Methods: We have used a prototype proton imaging system with single proton tracking to acquire proton radiography and proton CT images of a sample of porcine pectoral girdle and ribs, and a pig's head. We also acquired close in time x-ray CT scans of the same samples and compared proton stopping power measurements from the two modalities. In the case of the pig's head, we obtained x-ray CT scans from two different scanners and compared results from high-dose and low-dose settings. Results: Comparing our reconstructed proton CT images with images derived from x-ray CT scans, we find agreement within 1% to 2% for soft tissues and discrepancies of up to 6% for compact bone. We also observed large discrepancies, up to 40%, for cavitated regions with mixed content of air, soft tissue, and bone, such as sinus cavities or tympanic bullae. Conclusions:Our images and findings from a clinically realistic proton CT scanner demonstrate the potential for proton CT to be used for low-dose treatment planning with reduced margins. K E Y W O R D Sdigitally reconstructed radiograph, iterative algorithm, proton computed tomography, proton imaging, proton radiography, relative stopping power 7998

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Treatment of sinonasal undifferentiated carcinoma with neoadjuvant chemotherapy and proton therapy

Cited by 2 publications

References 8 publications

A Comparison of Proton Stopping Power Measured with Proton CT and x-ray CT in Fresh Post-Mortem Porcine Structures

A Comparison of Proton Stopping Power Measured with Proton CT and x-ray CT in Fresh Post-Mortem Porcine Structures

A comparison of proton stopping power measured with proton CT and x‐ray CT in fresh postmortem porcine structures

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