Treatment of Soft-Tissue Infection With Cephalexin

Page, J. W. J.

doi:10.1001/jama.1970.03170110043009

Cited by 14 publications

(2 citation statements)

References 4 publications

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“…Cephalexin, a first-generation cephalosporin, was approved by the Food and Drug Administration in 1967 for treatment of skin and soft tissue infections caused by Staphylococcus and Streptococcus based on initial studies that suggested 90% clinical improvement in cellulitis. 1 In 1981 a review of 15 small, heterogeneous clinical trials of the drug summarized the clinical cure rate at 91%, adding further support to cephalexin as a first-line oral agent for cellulitis. 2 Since then many new oral antibiotics that received indications for these infections were compared for equivalency with cephalexin.…”

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confidence: 99%

Increased Therapeutic Failure for Cephalexin versus Comparator Antibiotics in the Treatment of Uncomplicated Outpatient Cellulitis

Madaras‐Kelly

Arbogast²,

Jue

2000

Pharmacotherapy

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We reviewed records of outpatients to determine the therapeutic failure rate of cephalexin in treating uncomplicated cellulitis. Therapeutic failure was defined as an increase in antibiotic dosage, prescription renewal, or addition or substitution of another antibiotic. Demographics, physical characteristics, risk factors, intervention, and outcome data were collected. Twenty-seven percent of patients failed therapy with an oral antibiotic. The failure rate for cephalexin was 40% versus 20% for comparator antibiotics (p=0.02, odds ratio [OR] 2.62, 95% confidence interval [CI] 1.18-5.75). We identified no statistically significant variables related to cephalexin failure. Concomitant acid suppressive therapy was administered with cephalexin in 42% of failures and 20% of nonfailures (p=0.11, OR 2.78, 95% CI 0.77-9.87). These data suggest that cephalexin's efficacy was less than that of other antimicrobials in treating cellulitis, possibly related to concurrent acid suppression.

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confidence: 99%

Increased Therapeutic Failure for Cephalexin versus Comparator Antibiotics in the Treatment of Uncomplicated Outpatient Cellulitis

Madaras‐Kelly

Arbogast²,

Jue

2000

Pharmacotherapy

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“…Procedure was as follows: (1) Ten miligrams dry cephalexin in powder was dissolved in 10 ml sterile distilled water for comparative cephalexin standard. (2) The basic concentration was diluted with sterile distilled water to concentrations of 10, 5, 2.5, 1.25, 0.63, 0.32, 0.16, 0.08, and 0.04 p.g/ml, and 1 ml of each concentration of cephalexin was pipetted with sterile pipettes into sterile, capped tubes. Two controls were set up; one control with 1 ml sterile distilled water only, the second control with cephalexin at a concentration of 10 pg/ml.…”

Section: Range Of Bacterial Organisms Encounteredmentioning

confidence: 99%

A Clinical Study of Cephalexin

Roberts¹

1973

The Journal of Clinical Pharmacology and New Drugs

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Effectiveness and tolerance of cephalexin in children

1972

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Abstract. Oral cephalexin was used in 45 children, aged 3 weeks to 14 years in a medium dose of 27.4 mg/kg repeated every 6--8 hrs in 19 cases of pyelonephritis, 11 cases of pulmonary infection and 15 cases of various infections for an average of 14--21 days. Clinical and bacteriological results were excellent in UTI, favourable in the other groups, as far as to be objectivatcd. During the first hours of therapy blood and urine concentrations were measured. 1VIaximum concentrations in serum after a single dose were reached by children older than 1 year after 1 hr with 25.15 meg/ml, in infants only after 2 hrs with only 9.82 mcg/ml. Urine concentrations exceeded 1000 mcg/ml in 38 out of 42 patients. WBC and neutrophils were disminished, SGOT, SGPT and blood urea elevated, but remained within normal limits.

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Treatment of Soft-Tissue Infection With Cephalexin

Cited by 14 publications

References 4 publications

Increased Therapeutic Failure for Cephalexin versus Comparator Antibiotics in the Treatment of Uncomplicated Outpatient Cellulitis

Increased Therapeutic Failure for Cephalexin versus Comparator Antibiotics in the Treatment of Uncomplicated Outpatient Cellulitis

A Clinical Study of Cephalexin

Effectiveness and tolerance of cephalexin in children

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