Treatment of spinal hydatid disease: A single center experience

Sengul, Goksin; Kadıoğlu, Hakan Hadi; Kayaoğlu, Çetin Refik; Aktas, Sarper; Akar, Ali; Aydin, İsmail Hakkı

doi:10.1016/j.jocn.2007.03.015

Cited by 14 publications

(6 citation statements)

References 11 publications

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“…The location and the extent of the lesion(s) determine the surgical approach and the necessary surgical procedure (table 2). After resection of affected bone, a wide spectrum of techniques has been employed to stabilize the vertebral column (including bone grafts [17], [25]–[43], dorsal stabilisation by pedicle screw systems [9], [26], [27], [37], [44]–[48], Harrington- [9], [27], [36], [39], [49]–[51] and Luque- [9], [45], [50], [51] rods, vertebral body replacement by titanium cage implantation [44], [52], [53], plating [25], [35], [52], [54], bone cement [26], [55], [56]). However, in the absence of evidence no recommendations regarding the use of a specific technique can be given besides possibly bone grafting.…”

Section: Discussionmentioning

confidence: 99%

Spinal Cystic Echinococcosis – A Systematic Analysis and Review of the Literature: Part 2. Treatment, Follow-up and Outcome

et al. 2013

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Bone involvement in human cystic echinococcosis (CE) is rare, but affects the spine in approximately 50% of cases. Despite significant advances in diagnostic imaging techniques, surgical treatment and introduction of pharmacological therapy, spinal echinococcosis remains associated with a high degree of morbidity, disability and mortality.We systematically reviewed the published literature of the last five decades to update and summarize the currently existing data on treatment, follow-up and outcome of spinal CE.

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Section: Discussionmentioning

confidence: 99%

Spinal Cystic Echinococcosis – A Systematic Analysis and Review of the Literature: Part 2. Treatment, Follow-up and Outcome

et al. 2013

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“…Surgery, when feasible, and long-term chemotherapy are currently the treatments of choice for these cases, although outcomes may vary. 3,12,[27][28][29][30] Benzimidazoles (mebendazole 40-50 mg/kg/day and albendazole 10-15 mg/kg/day) are the drugs of choice for the medical treatment of cystic hydatid disease. Serum drug levels may vary widely in individual patients and thus correlation between oral doses and drug efficacy is inconsistent.…”

Section: Discussionmentioning

confidence: 99%

“…Bone involvement, especially of the spine and pelvis, is very difficult to treat and has a poor prognosis. 28,30 In addition, albendazole penetration in bone is probably low. Thus, response to therapy in these three patients was possibly not only secondary to antiparasitic drugs, but caused by a combination of drug therapy and specific disease localization.…”

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confidence: 99%

Evaluation of Nitazoxanide for the Treatment of Disseminated Cystic Echinococcosis: Report of Five Cases and Literature Review

Pérez‐Molina

Díaz‐Menéndez²,

Gallego³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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We aimed to evaluate the effectiveness of nitazoxanide in disseminated cystic echinococcosis (DCE) that failed to respond to surgical and antiparasitic therapy. We report on seven patients (five of them with bony involvement): two cases from the literature and five patients who were included in a compassionate trial of nitazoxanide therapy in our hospital. Median follow-up time until nitazoxanide therapy was 12 years and all patients had received prior medical treatment and extensive surgery. Nitazoxanide (500 mg/12 h) in combination with albendazole, with/without praziquantel, was administered for 3–24 months. Three patients improved: one with muscle involvement (clinico-radiological response), one with lung involvement (radiological response), and another with soft tissue and bony involvement (clinico-radiological response of soft tissue cysts). There was one discontinuation after 15 days of starting therapy. Nitazoxanide combination therapy could have a role in the treatment of DCE when there is no bony involvement. Long-term safety profile seems to be favorable.

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“…At present, the most widely recognized and accepted method of spine reconstruction was bone transplantation 17 . Most commonly used method were titanium cage interbody graft 18 or cage interbody fusion 19 and polymethylmethacrylate 20 to ll bone defects. All patients in this study received operation, but one patient recurred and refused treatment, nally died during the follow up time.…”

Section: Discussionmentioning

confidence: 99%

Surgical treatment in nervous system echinococcosis in Qinghai-Tibet Plateau

Du¹,

Li²,

Zhang³

et al. 2020

Preprint

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Purpose: To summarize the experience of diagnosis and treatment of echinococcosis in nervous system in Qinghai-Tibet Plateau.Methods: Patients with echinococcosis of nervous system treated in Qinghai Provincial People's Hospital from January 2010 to September 2018 were selected. All patients were examined by enzyme linked immunosorbent assay and imaging examination. During the hospital, all patients received surgery. After operation, patients exanimated regularly and followed up for one year.Results: A total of 13 patients were included in this study. The average age was 38.8±13.7 and seven cases (54%) were male. Among these patients, six cases had cystic echinococcosis and seven cases with alveolar echinococcosis, meanwhile, eight patients had cerebral echinococcosis and five patients with spinal echinococcosis. The enzyme linked immunosorbent assay indicated positive results in 8 cases and one patient was misdiagnosed as vertebral metastases by imaging examination before operation. One patient recurred after operation but refused treatment. After follow-up for one year, the mRS (Modified Rankin Scale) of cerebral echinococcosis improved from 3.3±0.5 to 2.1±0.4, four cases of spinal echinococcosis improved in ASIA (American Spinal Injury Association).Conclusion: Current evidence indicated that early surgical treatment and oral albendazole might improve the outcome of patients with nervous system echinococcosis in short time.

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Treatment of spinal hydatid disease: A single center experience

Cited by 14 publications

References 11 publications

Spinal Cystic Echinococcosis – A Systematic Analysis and Review of the Literature: Part 2. Treatment, Follow-up and Outcome

Spinal Cystic Echinococcosis – A Systematic Analysis and Review of the Literature: Part 2. Treatment, Follow-up and Outcome

Evaluation of Nitazoxanide for the Treatment of Disseminated Cystic Echinococcosis: Report of Five Cases and Literature Review

Surgical treatment in nervous system echinococcosis in Qinghai-Tibet Plateau

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