Treatment of Stage IV Malignant Rhabdoid Tumor of the Kidney (MRTK) With ICE and VDCy

Yamamoto, Masaki; Suzuki, Nobuhiro; Hatakeyama, Naoki; Mizue, Nobuo; Hori, Tsukasa; Kuroiwa, Yuki; Hareyama, Masato; Oda, Takanori; Kudoh, Tooru; Nui, Akihiro; Matsuno, Takashi; Hirama, Toshinori; Yokoyama, Shigeaki; Dome, Jeffrey S.; Tsutsumi, Hiroyuki

doi:10.1097/01.mph.0000212901.84146.5a

Cited by 30 publications

(27 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Oxaliplatin has not proven to be effective in patients with refractory Rhabdoid tumors (20). Surgical radicality seems to be of prognostic value in RT of the kidney and AT/RT (12,19). Although in our population, this factor did not show any significant difference in outcome, future strategies should aim to complete surgical removal of the tumor.…”

Section: Discussionmentioning

confidence: 63%

“…Chemotherapeutic regimens should include drugs that were formerly regarded as effective like anthracyclines and alkylating agents. The combination of ifosfamide, carboplatinum and etoposide is efficient against RT of the kidney (19) and AT/RT (18). Recent unpublished chemotherapy strategies in North America and Germany prefer intensive multi-drug protocols including topoisomerase I inhibitors in combination with the 'classic' drugs.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Rhabdoid tumors in children: Prognostic factors in 70 patients diagnosed in Germany

Reinhard¹,

Reinert²,

Beier³

et al. 2008

Oncol Rep

View full text Add to dashboard Cite

Abstract.We retrospectively analysed the data of 70 patients (41 boys and 29 girls) with Rhabdoid tumors (RT) regardless of localisation, recorded in the German Childhood Cancer Registry (GCCR) from 1984 to 1999. The primary tumor was located in the kidney in 32 cases, in the central nervous system (CNS) in 13 cases and in the soft tissue in 25 cases. Variables examined were tumor stage, sex, age at diagnosis, surgical radicality, radiotherapy and chemotherapeutic regimens. Metastatic disease at diagnosis was observed in 18 of the 70 individuals. Outcome of this group was very poor with a 5-year overall survival of 11%. There were no differences in survival between males and females, or younger and older children. Chemotherapeutic regimens were mainly given according to the primary site of the tumor. Radiotherapy was given in 28 of the 70 patients with a mean dose of 35 Gray, though this did not improve the outcome. Overall survival of the whole cohort was 27% at 5 years and there was no significant difference in prognosis regarding the different locations of the tumor (kidney 24%, soft tissue 30%, CNS 29%). In conclusion, RT in infants and children has a dismal prognosis, independent from localisation. The presence of metastasis at diagnosis seems to be the only prognostic factor of outcome.

show abstract

Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Rhabdoid tumors in children: Prognostic factors in 70 patients diagnosed in Germany

Reinhard¹,

Reinert²,

Beier³

et al. 2008

Oncol Rep

View full text Add to dashboard Cite

show abstract

“…There are no effective or standard treatment strategies that are currently available for these tumors and prognosis is poor (1,2). The majority of RTs arise because of loss of heterozygosity (LOH) at the INI1/hSNF5 gene locus and harbor recurrent biallelic alterations (deletions and point mutations) in the gene irrespective of tissue or origin of the tumors (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Aurora AIs a Repressed Effector Target of the Chromatin Remodeling Protein INI1/hSNF5 Required for Rhabdoid Tumor Cell Survival

et al. 2011

View full text Add to dashboard Cite

Rhabdoid tumors (RT) are aggressive pediatric malignancies with poor prognosis. INI1/hSNF5 is a component of the chromatin remodeling SWI/SNF complex and a tumor suppressor deleted in RT. Previous microarray studies indicated that reintroduction of INI1/hSNF5 into RT cells leads to repression of a high degree of mitotic genes including Aurora Kinase A (Aurora A, STK6). Here, we found that INI1/SNF5 represses Aurora A transcription in a cell-type-specific manner. INI1-mediated repression was observed in RT and normal cells but not in non-RT cell lines. Chromatin immunoprecipitation (ChIP) assay indicated that INI1/hSNF5 associates with Aurora A promoter in RT and normal cells but not in non-RT cells. Real-time PCR and immunohistochemical analyses of primary human and mouse RTs harboring mutations in INI1/hSNF5 gene indicated that Aurora A was overexpressed/derepressed in these tumor cells, confirming that INI1/hSNF5 represses Aurora A in vivo. Knockdown of Aurora A impaired cell growth, induced mitotic arrest and aberrant nuclear division leading to decreased survival, and increased cell death and caspase 3/7-mediated apoptosis in RT cells (but not in normal cells). These results indicated that Aurora A is a direct downstream target of INI1/hSNF5-mediated repression in RT cells and that loss of INI1/hSNF5 leads to aberrant overexpression of Aurora A in these tumors, which is required for their survival. We propose that a high degree of Aurora A expression may play a role in aggressive behavior of RTs and that targeting expression or activity of this gene is a novel therapeutic strategy for these tumors. Cancer Res; 71(9); 3225-35. Ó2011 AACR.

show abstract

“…Показано, что на выживаемость влияет использование высоких доз алкилирующих агентов, в том числе антрациклино-вых антибиотиков и актиномицина D [9,80]. Также отмечено влияние альтернирующих курсов терапии в комбинации с такими препаратами, как винкри-стин, циклофосфамид, доксорубицин (VDC) и ифос-фамид, карбоплатин, этопозид (ICE) на метастати-ческую форму заболевания [81,82]. На протяжении длительного времени в лечении ЗРО почек и мягких тканей использовались различные протоколы те-рапии (SIOP и NWTS/IRS III, UKW2), основанные на комбинации данных терапевтических агентов.…”

Section: результаты лечения злокачественных рабдоидных опухолейunclassified

Malignant rhabdoid tumors of soft tissues in children. Literature review

Телешова¹

2017

Ross. ž. det. gematol. onkol.

View full text Add to dashboard Cite

Treatment of Stage IV Malignant Rhabdoid Tumor of the Kidney (MRTK) With ICE and VDCy

Cited by 30 publications

References 10 publications

Rhabdoid tumors in children: Prognostic factors in 70 patients diagnosed in Germany

Rhabdoid tumors in children: Prognostic factors in 70 patients diagnosed in Germany

Aurora AIs a Repressed Effector Target of the Chromatin Remodeling Protein INI1/hSNF5 Required for Rhabdoid Tumor Cell Survival

Malignant rhabdoid tumors of soft tissues in children. Literature review

Contact Info

Product

Resources

About