Treatment of Strongyloidiasis with Mebendazole-Long Term Eradication and New Trials

Shikiya, K; Kuniyoshi, T; Uechi, Hiroyuki; Oyakawa, Tominori; Kinjo, Fukunori; Saitô, Atsushi; Ikema, Minoru; Nakamura, Hiroshi; Yamashiro, Masato; Asato, Ryuji

doi:10.11150/kansenshogakuzasshi1970.65.433

Cited by 6 publications

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“…Thiabendazole is strongly active in eradicating the organism, but it is well known that the rate of severe side effects is extremely high (4)(5)(6). Mebendazole is also active against S. ster coralis (7,8), but a high incidence of liver disfunction was shown in our previous studies (9,10). Ivermectin (IVM) has recently been found to be safe and effective for treatment of human onchocerciasis (ll-14) and lymphatic filariasis (15), but there are only two published reports concerning the efficacy of IVM against S. ster coralis in humans (16, 17).…”

Section: Introductionmentioning

confidence: 92%

“…We then treated 47 patients for 5 day periods, repeating the treatment at 1, 3 and 4 weeks following the initial 5 day treatment. The eradication rate was 100% , but liver disfunction still occurred in 48.9% of the patients (10). IVM is a semisynthetic macrocyclic lactone (a fer mentation product of an actinomycete, Streptomyces avermitilis).…”

Section: Antiparasitic Effectmentioning

confidence: 99%

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Efficacy of Ivermectin against Strongyloides Stercoralis in Humans.

et al. 1992

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Okinawa Prefecture is an endemic area of Strongyloides stercoralis infection. Since treat ment of this infection remains unsatisfactory, we evaluated the efficacy of ivermectin. Twenty three patients were treated with a single oral dose of ivermectin (mean ± SD, 105.5 ± 20.8 meg/ kg of body weight), followed by a second dose two weeks later. The rate of cure was 85.7% at 2 weeks after the first treatment, and 90.5% at 2 weeks after the second treatment. Side effects occurred in 2 patients (8.7%), but they were mild and transient. The results indicate that ivermectin might be useful and relatively safe for the therapy of Strongyloides stercoralis infection as an alternative to thiabendazole or mebendazole. (Internal Medicine 31: 310-312, 1992)

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Section: Introductionmentioning

confidence: 92%

Section: Antiparasitic Effectmentioning

confidence: 99%

Efficacy of Ivermectin against Strongyloides Stercoralis in Humans.

et al. 1992

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RETRACTED ARTICLE: Development of a safe antiparasitic against scuticociliates (Miamiensis avidus) in olive flounders: new approach to reduce the toxicity of mebendazole by material remediation technology using full-overlapped gravitational field energy

Seo

Kim²,

Jeon³

et al. 2018

Parasitol Res

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The olive flounder (Paralychthys olivaceus) is a representative farmed fish species in South Korea, which is cultured in land-based tanks and accounts for approximately 50% of total fish farming production. However, farmed olive flounder are susceptible to infection with parasitic scuticociliates, which cause scuticociliatosis, a disease resulting in severe economic losses. Thus, there has been a longstanding imperative to develop a highly stable and effective antiparasitic drug that can be rapidly administered, both orally and by bath, upon infection with scuticociliates. Although the efficacy of commercially available mebendazole (MBZ) has previously been established, this compound cannot be used for olive flounder due to hematological, biochemical, and histopathological side effects. Thus, we produced material remediated mebendazole (MR MBZ), in which elements comprising the molecule were remediated by using full-overlapped gravitational field energy, thereby reducing the toxicity of the parent material. The antiparasitic effect of MR MBZ against scuticociliates in olive flounder was either similar to or higher than that of MBZ under the same conditions. Oral (100 and 500 mg/kg B.W.) and bath (100 and 500 mg/L) administrations of MBZ significantly (p < 0.05) increased the values of hematological and biochemical parameters, whereas these values showed no increase in the MR MBZ administration group. In addition, there were no histopathological side effects, such as atrophic degeneration or hyaline droplet degeneration, whereas these were observed when MBZ was administered. Thus, we report that the material remediation method using full-overlapped gravitational field energy can be used to reduce drug toxicity.

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