Aim - to analyze the results of the use of 3D modeling and computer navigation in the treatment of benign tumors and tumor-like diseases of long bones. Materials and methods. The study included 19 patients with benign tumors and tumor-like diseases. The main group consisted of 10 patients. In the preoperative planning stage, in addition to X-ray and computed tomography these patients had 3D-models of the affected bone segment constructed. Surgical treatment was carried out with the use of the navigation system. The control group consisted of 9 patients who underwent radiography and computed tomography of the affected bone segment in the preoperative planning stage. Results. The application of the new method made possible to reduce the operation time by 40 min, intraoperative blood loss by 350 ml, and the intensity of pain on a visual analog scale by more than 2 points. This result was achieved by intuitively simple for the operator dimensional orientation in the operative field in real time, the possibility of more accurate surgical procedures due to a more precise calculation of the level of necessary transplant. It minimizes the trauma of the donor area, exerting a positive influence on the reduction of postoperative pain. Conclusion. The use of 3D modeling and computer navigation for the treatment of patients with benign tumors and tumor-like diseases of long bones managed to improve noticeably the results of surgical treatment, and consequently, to speed up social and functional adaptation of patients and to enhance social and economic outcome.