Treatment of synchronous adenocarcinoma and lymphoma of the stomach: A case report

Weng, Chien‐Hsiang; Wang, Ren‐Ching; Wu, Cheng‐Chung; Lin, Tseng‐Hsi

doi:10.3892/mco.2016.1044

Cited by 6 publications

(5 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similarly, 57 patients were reported in a review of such cases by Namikawa et al for a study period from 1990 to 2013 in 2014 [ 12 ]. Subsequently, similar individual cases were reported by Weng CH et al in 2016 [ 13 ] and Meng et al in 2019 [ 14 ]. Synchronous primary gastric triple-hit high-grade B-cell lymphoma and gastric adenocarcinoma were reported by Claudia C et al in 2021 [ 15 ], and a case of T-cell lymphoma and gastric adenocarcinoma was reported by Narcisa G et al in 2021 [ 16 ].…”

Section: Discussionsupporting

confidence: 80%

Synchronous Adenocarcinoma Stomach With Marginal Zone Lymphoma: A Sporadic Occurrence and Review of Literature

Upadhyay¹,

Shekhar²,

Pandey³

et al. 2023

Cureus

View full text Add to dashboard Cite

Synchronous adenocarcinoma of the stomach with lymphoma is extremely rare. We report a case of a 65-year-old male patient with synchronous adenocarcinoma of the stomach with nodal marginal zone lymphoma. Initial endoscopic biopsy suggested invasive moderately differentiated adenocarcinoma and a locoregional disease, per contrast-enhanced computed tomography (CECT) scans. The patient was started on neo-adjuvant chemotherapy with the 5FU, leucovorin, oxaliplatin, docetaxel (FLOT) regime and, after response evaluation, underwent radical gastrectomy. Histopathology and immunohistochemistry suggested synchronous adenocarcinoma of the stomach with marginal zone lymphoma in perigastric lymph nodes. This case is probably the first such synchronous malignancy case reported from India. The prognosis of multiple primary malignancies is usually poor because no standard guidelines are available regarding optimum treatment and sequencing of available treatment modalities. The frequency of synchronous primary cancers has been increasing in recent years, probably due to better diagnostic modalities, and second primary in patients with cancer should be considered as one of the differential diagnoses.

show abstract

Section: Discussionsupporting

confidence: 80%

Synchronous Adenocarcinoma Stomach With Marginal Zone Lymphoma: A Sporadic Occurrence and Review of Literature

Upadhyay¹,

Shekhar²,

Pandey³

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…1). [12–262] The data were extracted from the abstract in 34 articles, [17,37–39,64,75,76,78,81,94,97,103,129,134,151,162,166,170,174,176,192,195,212,221,222,229,232,234,251,252,256,260–262] of which 21 were in English, 5 in Japanese, 3 in Spanish, 2 in French, 2 in Chinese, and 1 in Czech.…”

Section: Resultsmentioning

confidence: 99%

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

et al. 2022

View full text Add to dashboard Cite

Background: The presence of a lymphoma associated with a solid synchronous neoplasm or collision neoplasm has been rarely in the literature, and a detailed characterization of these cases is lacking to date.Objective: To describe the main clinicopathological features of synchronous/collision tumors.Methods: A systematic search in PubMed, Scielo, and Virtual Health Library literature databases for cases or case series of synchronous or collision lymphoma and other solid neoplasms reported up to March 2021 was performed. Three reviewers independently screened the literature, extracted data, and assessed the quality of the included studies. The systematic review was performed following the Preferred Reporting Items for Systematic Meta-Analyses guidelines.Results: Mean age of patients was 62.9 years (52.9% men). A total of 308 cases were included (62% synchronous and 38% collision). The most frequent location of both synchronous and collision tumors was the gastrointestinal tract with the most common solid neoplasm being adenocarcinoma, and the most frequent lymphoma diffuse large B-cell lymphoma (21.7%) and mucosa-associated lymphoid tissue lymphoma (20.4%). Of the total number of mucosa-associated lymphoid tissue lymphomas and gastric adenocarcinomas, the presence of Helicobacter pylori infection was documented in 47.3% of them. Only 2% of all cases had a previous history of lymphoma. Thus, in most cases (98%), lymphoma was discovery incidentally. In addition, nodal lymphoma was associated with metastasis in 29 (9.4%) cases as collision tumor, most commonly (90%) in locoregional lymph nodes of the solid neoplasm. Conclusions:The frequent association of some type of B-cell lymphoma and adenocarcinoma in synchronous/collision tumors of the gastrointestinal tract points to common pathogenic mechanisms in both neoplasia, particularly related to chronic inflammation in this location. In most cases, lymphoma identified in locoregional lymph nodes or distant of a carcinoma seems to represent an incidental finding during the carcinoma diagnostic/therapeutic approach. A synergy between carcinoma and lymphoma (involving inflammation and immunosuppression mechanisms) may favor tumor progression and dissemination. A better understating of the interactions lymphoma/carcinoma in the setting of synchronous/collision tumors may help to improve patient management and prognosis.

show abstract

“…Synchronous multiple primary cancers are defined as two or more tumors occurring within 6 months of each other [7], and among them, synchronous gastric cancer and primary extranodal DLBCL are rare. To the best of our knowledge, 13 cases of synchronous gastric cancer and primary gastric DLBCL and two cases of synchronous gastric cancer and primary small intestinal DLBCL have been reported in English [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. Particularly, the patient in this case report is the first reported case of synchronous gastric cancer and primary adrenal DLBCL in the English literature.…”

Section: Discussionmentioning

confidence: 99%

Synchronous gastric cancer and primary lymphoma of right adrenal gland: a case report

Fukuda

Wakasa

Hanamoto

et al. 2021

Clin J Gastroenterol

View full text Add to dashboard Cite

This report presents an extremely rare case of synchronous gastric cancer and primary adrenal diffuse large B-cell lymphoma (DLBCL). An 82-year-old man underwent computed tomography, which revealed a heterogeneous appearing and hypodense adrenal mass and a gastric mass with no enlarged lymph nodes in the neck, mediastinum, abdomen, and inguinal region. Upper gastrointestinal endoscopy revealed a protruding gastric tumor. The specimens obtained from endoscopic biopsy were histologically confirmed to be adenocarcinoma. The hormonal findings eliminated functional adrenal tumor. The patient underwent distal gastrectomy with regional lymph node resection for gastric cancer and incisional biopsy of the adrenal mass. Based on the pathological findings, diagnoses of mixed mucinous and tubular adenocarcinomas of the stomach and adrenal DLBCL were confirmed. Postoperation, the patient received rituximab combined with low-dose doxorubicin, cyclophosphamide, vincristine, and prednisone (R-miniCHOP). Six courses of R-miniCHOP were planned, but were completed in only one course at the patient’s request. The patient died 2 months after surgery.

show abstract

Treatment of synchronous adenocarcinoma and lymphoma of the stomach: A case report

Cited by 6 publications

References 24 publications

Synchronous Adenocarcinoma Stomach With Marginal Zone Lymphoma: A Sporadic Occurrence and Review of Literature

Synchronous Adenocarcinoma Stomach With Marginal Zone Lymphoma: A Sporadic Occurrence and Review of Literature

Synchronous or collision solid neoplasms and lymphomas: A systematic review of 308 case reports

Synchronous gastric cancer and primary lymphoma of right adrenal gland: a case report

Contact Info

Product

Resources

About