Treatment of Syringoma Using an Ablative 10,600-nm Carbon Dioxide Fractional Laser: A Prospective Analysis of 35 Patients

Abstract

The use of CO(2) FS can have a positive therapeutic effect on periorbital syringomas.

Treatment of periorbital syringoma by the pinhole method using a carbon dioxide laser in 29 Asian patients

“…In a previous investigation, we demonstrated that CO 2 fractional lasers offered positive therapeutic effects in 35 Korean patients with periorbital syringomas (6). In our study, two sessions of CO 2 fractional laser treatment at one-month intervals with the laser settings of a pulse energy of 100 mJ and a density of 200-300 spots/cm 2 resulted in marked to near-total clinical improvement in 51.5% of the participants (6).…”

“…Therefore, to more safely deliver higher pulse energy to a larger area, CO 2 lasers with fractional irradiation technology have been used (10). however, as shown in our previous study, the percent coverage of CO 2 fractional lasers was usually limited to 10-30% of the treated area; moreover, improvement scores seemed to decrease with time after CO 2 fractional laser treatment alone, necessitating repeated treatments to achieve satisfactory outcomes in patients with refractory syringoma lesions (6).…”

“…In addition to the direct destructing effect of CO 2 lasers on dermal neoplasms, thermal stimulation to the surrounding tissues is also known to induce neocollagenesis and remodeling of the dermal matrix (11). Therefore, CO 2 -laser-induced realignment and regeneration of dermal tissues as well as fibrous tissues, which surround syringoma lesions, can result in clinical improvement of skin texture (5,6). Nevertheless, pinhole methods require longer procedure times for the treatment of numerous syringoma lesions across a large area.…”

“…In our study, two sessions of CO 2 fractional laser treatment at one-month intervals with the laser settings of a pulse energy of 100 mJ and a density of 200-300 spots/cm 2 resulted in marked to near-total clinical improvement in 51.5% of the participants (6). In addition, Park et al (7) retrospectively reviewed 11 patients with syringomas treated by making multiple holes in each lesion with a CO 2 laser for a mean number of 2.2 treatment sessions at four-to six-week intervals, and reported that all of the participants presented good to excellent cosmetic outcomes.…”

Periocular syringomas – Successful treatment with fractional CO2 laser

“…Syringomas are eccrine benign tumors of skin occurring A B [16] * BoTN -Botulinum toxin most frequently in the head and neck area. As suggested by our own experience, fractional CO 2 laser may be an effective and safe tool to improve facial appearance for the treatment of multiple periocular syringomas that poorly respond to ablative CO 2 laser.…”