Treatment of Tetanus With Curarisation, General Anæsthesia, and Intratracheal Positive-Pressure Ventilation

Lassen, H. C. A.; Bjørneboe, M.; Ibsen, B; Neukirch, F

doi:10.1016/s0140-6736(54)90604-2

Cited by 84 publications

(17 citation statements)

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“…But not necessarily so: there were E.C.G. changes in both our patients who survived, and in one of the cases reported by Lassen et al (1954) the patient had E.C.G. changes of supraventricular paroxysmal tachycardia yet recovered.…”

Section: Discussionmentioning

confidence: 55%

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Total Paralysis Regime in Severe Tetanus

Alhady¹,

Bowler²,

Reid³

et al. 1960

BMJ

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Section: Discussionmentioning

confidence: 55%

“…In Case 7. however, microscopy revealed an acute toxic myocarditis. Lassen et al (1954) recorded histological evidence of myocarditis in one of their four patients treated by I.P.P.R. But the patient had septicaemia.…”

Section: Discussionmentioning

confidence: 99%

Total Paralysis Regime in Severe Tetanus

Alhady¹,

Bowler²,

Reid³

et al. 1960

BMJ

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“…Similar experiences and poor responses to treatment with antibiotics and steroids have been reported from other centres (Clifton, 1964;Adams et al, 1966;Clark and Taylor, 1966;Macrae, 1967). It has also been suggested that toxic myocarditis could be a cause of hypotension in tetanus (Lassen et al, 1954;Alhady et al, 1960;Stirnemann, 1966;Macrae, 1967). There was no evidence from the electrocardiograms of our patients to suggest myocarditis and the central venous pressure did not rise as in heart failure.…”

Section: Discussionmentioning

confidence: 99%

Hypotension in Tetanus

Corbett¹,

Spalding²,

Harris³

1973

BMJ

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SummaryThree patients with severe tetanus had episodes of profound arterial hypotension lasting from minutes to hours. The blood pressure was recorded continuously for 13, 19, and six days respectively by an intra-arterial catheter, and other measurements Included heart rate, central venous pressure, cardiac output, and blood gases.The hypotension was distinguished from that of "shock", for there was no clinical evidence of peripheral vasoconstriction and no tachycardia. It could not be attributed to disturbances of salt and water balance. During episodes of hypotension the blood pressure feil as low as 32/16 mm Hg, the heart rate fell from a mild tachycardia to normal values or a mild bradycardia, and the central venous pressure did not rise. The onset lnd the end of such episodes was often abrupt and the hypotension was often produced in response to a stimulus. In one patient extreme hypotension foilowed the aspiration of secretions from the trachea. These changes may represent another effect of tetanus on autonomic nervous activity, including impairment of baroreceptor reflexes.

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“…Tetanus is a serious disease, the mortality of which was as high as 70% before Lassen et al (1954) described the use of total paralysis and intermittent positive-pressure ventilation.…”

Section: Commentmentioning

confidence: 99%