Treatment of the brain-dead lung donor with aprotinin and nitric oxide

The implications of brain death in donor lung injury: investigation and blockade of the endothelin axis

“…Avlonitis et al investigated inhaled NO administered to BD rodent donors prior to lung transplantation. [193] This study observed that, contrary to previous living donor experiments, NO worsened oxygenation without improving systemic markers of inflammation. The authors concluded that NO administration to BD organ donors was of no benefit, and could actually lead to harm.…”

“…[193] TNF-α levels initially rose and then decreased by five hours, though it remained above baseline. [193] Zhu et al showed that gradual induction of brain death lead to steady elevation of IL-1β over 24…”

“…[129,192] Animal models have shown that serum levels of IL-1β and TNF-α may be influenced by the rate of induction of brain death. [41,193] Avlonitis et al reported that explosive brain death induced a rapid increase in IL-1β, with significantly elevated levels detectable within one hour and remaining so throughout the duration of the study. [193] TNF-α levels initially rose and then decreased by five hours, though it remained above baseline.…”

“…[41,193] Avlonitis et al reported that explosive brain death induced a rapid increase in IL-1β, with significantly elevated levels detectable within one hour and remaining so throughout the duration of the study. [193] TNF-α levels initially rose and then decreased by five hours, though it remained above baseline. [193] Zhu et al showed that gradual induction of brain death lead to steady elevation of IL-1β over 24…”

“…The authors concluded that NO administration to BD organ donors was of no benefit, and could actually lead to harm. [193] Similar to NO, research into inhaled prostacyclin therapy for lung preservation has focussed on preventing IRI. Consequently, animal models have used non-BD donors.…”