Treatment of the Fluoroquinolone‐Associated Disability: The Pathobiochemical Implications

Michalak, Krzysztof Piotr; Sobolewska-Włodarczyk, Aleksandra; Włodarczyk, Marcin; Sobolewska, Justyna; Woźniak, Piotr; Sobolewski, Bogusław

doi:10.1155/2017/8023935

Cited by 53 publications

(44 citation statements)

References 107 publications

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“…Fluoroquinolones are a group of broad-spectrum antibiotics that can effectively kill or stop the growth of gram-negative and gram-positive bacteria [1]. For this reason, they are routinely prescribed by internists, family practitioners, specialists, subspecialists and surgeons [2].…”

Section: Introductionmentioning

confidence: 99%

Relationship between fluoroquinolones and the risk of aortic diseases: a meta-analysis of observational studies

Dai

Yang

Ma³

et al. 2020

BMC Cardiovasc Disord

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Background: Our aim was to determine the relationship between the use of fluoroquinolones and the risk of aortic diseases. Methods: PubMed, EMBASE and the Web of Science were searched from inception to July 6, 2019, to identify observational studies that evaluated the risk of aortic diseases associated in users of fluoroquinolones compared with nonusers or users of other antibiotics. The primary outcome was the first occurrence of aortic diseases. We used the GRADE approach to rate the strength of evidence. We used the inverse variance method random-effect model to estimate the odds ratios (ORs) with 95% CIs, and statistical heterogeneity was assessed by the I 2 statistic. Results: This meta-analysis enrolled 2,829,385 patients reported the relationship between fluoroquinolones and the risk of aortic diseases. Compared with nonusers or users of other antibiotics, users of fluoroquinolone had a significantly increased risk of aortic diseases (adjusted OR, 2.10; 95% CI, 1.65-2.68; P = .000, I 2 = 16.4%). The quality of evidence was moderate, and the number needed to harm (NNH) for aortic diseases among patients was estimated to be 1301. Conclusions: The fluoroquinolone use in patients significantly increases the risk of new-onset aortic diseases. Clinicians need to pay attention to these severe adverse events when considering fluoroquinolone use.

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Section: Introductionmentioning

confidence: 99%

Relationship between fluoroquinolones and the risk of aortic diseases: a meta-analysis of observational studies

Dai

Yang

Ma³

et al. 2020

BMC Cardiovasc Disord

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“…The forms of long-term affections are problematic (fatigue, problems with concentration, neuropathy, anxiety, depression, insomnia, fits of panic, depersonalization, suicidal thoughts), beginning days after the commencement of fluoroquinolones administration and outlasting even months after termination of administration. Effective therapy of these chronic conditions turned out to be complicated (Kaur et al 2016, Michalak et al 2017. No study of the effect of fluoroquinolones restriction on decreased unwanted effects has been published for the time being.…”

Section: Paterova Et Al: Effect Of Fluoquinolone Restriction On Bactmentioning

confidence: 99%

Effects of Fluoroquinolone Restriction In the hospital on the Development Of sensitivity of Selected Bacterial Pathogens

Paterová¹,

Ryšková²,

Fajfr³

et al. 2020

Mil. Med. Sci. Lett.

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Introduction: Fluoroquinolones are a frequently prescribed class of antibiotics, which has been blacklisted in recent years because of a growing evidence of the connection with serious undesirable effects, infections Clostridioides difficile, and a connection with the occurrence of multiresistant strains. Methods: In the University Hospital Hradec Kralove in the course of the years 2009-2019, several antibiotic stewardship restrictive and educational interventions were performed by the Antibiotic Centre aiming to decrease quinolone antibiotics administration. The data of the consumption of quinolone antibiotics were retrospectively evaluated and correlated with the development of sensitivity and occurrence of multiresistance of selected bacteria in the hospital. Results: In the period under investigation, consumption of fluoroquinolone antibiotics significantly decreased (p<0.001) in 10 years by 71.8% to 26.7 DDD/1000 patient day. Sensitivity of Escherichia coli and Pseudomonas aeruginosa to fluoroquinolones in the period under investigation increased by 4.8% (respectively by 15%); on the other hand, sensitivity of Staphylococcus aureus decreased by 4.2% to 85.5% share of sensitive strains. The incidence of the multiresistant isolates Pseudomonas aeruginosa decreased by 8.1%, but the occurrence of ESBL-producing Klebsiella pneumoniae was increased in the period under investigation. The occurrence of methicillin-resistant Staphylococcus aureus did not show a stable trend and finally it was moderately increased by 2.9%. Paterova et al.: Effect of fluoquinolone restriction on bacterial sensitivity IN PRESS Conclusion: Implementation of programmes of antimicrobial stewardship for hospitalized patients resulted in a decrease and a rationalization of fluoroquinolone administration. The reduction of their consumption in our hospital resulted in a statistically insignificant increase in the sensitivity of Escherichia coli and Pseudomonas aeruginosa, but not Staphylococcus aureus.

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“…Fluoroquinolones are a group of broad-spectrum antibiotics that can effectively kill or stop the growth of gram-negative and gram-positive bacteria. [1] For this reason, they are routinely prescribed by internists, family practitioners, specialists, subspecialists and surgeons. [2] However, several studies have reported serious adverse events, such as aortic aneurysm and aortic dissection, [3,4] in patients using fluoroquinolones.…”

Section: Introductionmentioning

confidence: 99%

Relationship between fluoroquinolones and the risk of aortic diseases: a meta-analysis of observational studies

Dai

Yang

et al. 2020

Preprint

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Background. Our aim was to determine the relationship between the use of fluoroquinolones and the risk of aortic diseases.Methods. PubMed, EMBASE and the Web of Science were searched from inception to July 6, 2019, to identify observational studies that evaluated the risk of aortic diseases associated in users of fluoroquinolones compared with nonusers or users of other antibiotics. The primary outcome was the first occurrence of aortic diseases. We used the GRADE approach to rate the strength of evidence. We used the inverse variance method random-effect model to estimate the odds ratios (ORs) with 95% CIs, and statistical heterogeneity was assessed by the I2 statistic.Results. This meta-analysis enrolled 2,829,385 patients reported the relationship between fluoroquinolones and the risk of aortic diseases. Compared with nonusers or users of other antibiotics, users of fluoroquinolone had a significantly increased risk of aortic diseases (adjusted OR, 2.10; 95% CI, 1.65-2.68; P=.000, I2=16.4%). The quality of evidence was moderate, and the number needed to harm (NNH) for aortic diseases among patients was estimated to be 1301.Conclusions. The fluoroquinolone use in patients significantly increases the risk of new-onset aortic diseases. Clinicians need to pay attention to these severe adverse events when considering fluoroquinolone use.

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Treatment of the Fluoroquinolone‐Associated Disability: The Pathobiochemical Implications

Cited by 53 publications

References 107 publications

Relationship between fluoroquinolones and the risk of aortic diseases: a meta-analysis of observational studies

Relationship between fluoroquinolones and the risk of aortic diseases: a meta-analysis of observational studies

Effects of Fluoroquinolone Restriction In the hospital on the Development Of sensitivity of Selected Bacterial Pathogens

Relationship between fluoroquinolones and the risk of aortic diseases: a meta-analysis of observational studies

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