Treatment of the Mayer–Rokitansky–Küster–Hauser syndrome with autologous in vitro cultured vaginal tissue: descriptive study of long‐term results and patient outcomes

Abstract

Vaginoplasty using in vitro vaginal tissue ensures a satisfactory sexual function and improves quality of life.

Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome: a comprehensive update

“…Surgical procedures include vaginoplasties using various autografts such as McIndoe vaginoplasty (split-skin graft covering a mold placed in the dissected pouch between the rectum and bladder), Baldwin vaginoplasty (bowel graft), Davydov vaginoplasty (peritoneal graft), and Williams vulvavaginoplasty (labia majora flaps) [ 128 – 131 ]. More recently, vaginoplasties using cultured autologous vulvar tissue [ 132 , 133 ] and tissue-engineered biomaterial [ 134 ] have been suggested. An alternative surgical procedure is the laparoscopic Vecchietti vaginoplasty in which a surgical traction device is placed on the anterior abdominal wall with subperitoneal threads attached to a mold in the vagina [ 135 , 136 ].…”

Psychological impact and health-related quality-of-life outcomes of Mayer–Rokitansky–Küster–Hauser syndrome: A systematic review and narrative synthesis

“…Of these 22 studies, 16 (73%) were quantitative, 2 (9%) were qualitative, and 4 (18%) used a mixed-methods design. Six studies (27%) focused on the outcomes of specific treatments, mainly surgical procedures (Carrard et al, 2012; Cheikhelard et al, 2018; Gatti et al, 2010; Labus et al, 2011; Leithner et al, 2015; Sabatucci et al, 2019). Most of these studies examined not only sexual function but also women’s body image and genital perception, sense of femininity, self-esteem, as well as psychological symptoms and QoL.…”

“…Two studies were conducted out of Europe, specifically in North America (Ernst et al, 2016) and Australia (Kimberley et al, 2011), and one study involved both Italy and Bangladesh (Gatti et al, 2010). Only one study reported longitudinal findings (Sabatucci et al, 2019). Two articles (Ernst et al, 2016; Patterson et al, 2016) described findings from qualitative studies providing an in-depth exploration of women’s lived experience of MRKH syndrome, while the remaining 19 articles (86%) reported cross-sectional results.…”

Simultaneous correction of breast hypertrophy and vaginal agenesis: Aesthetic surgery to the aid of reconstructive surgery

“…This study demonstrated that vaginoplasty performed with the use of autologous vaginal tissue ensured normal sex life, and a durable improvement in QoL. Anyway, authors concluded that even if this technique is fast and does not leave scars it can only be performed in specialized centers with a cell factory that meets good manufacturing practice (GMP) requirements, and that it is necessary to coordinate the availability of the operating room with the needs of the laboratory when the tissue is ready to be transplanted . Lin et al first described the use of autologous buccal mucosa for inner neovagina lining.…”

“…Anyway, authors concluded that even if this technique is fast and does not leave scars it can only be performed in specialized centers with a cell factory that meets good manufacturing practice (GMP) requirements, and that it is necessary to coordinate the availability of the operating room with the needs of the laboratory when the tissue is ready to be transplanted. 10 Lin et al first described the use of autologous buccal mucosa for inner neovagina lining. This technique has the advantage of leaving no scar but the limit of the small amount mucosa that is possible to harvest that the authors reported to be 6-8 × 2.5 cm.…”