Treatment of the Nasal Carrier of Staphylococcus Aureus With Framycetin and Other Antibacterials

Stratford, Bryan C.; Rubbo, SydneyD.; Christie, Robert W.; Dixson, Shirley

doi:10.1016/s0140-6736(60)92417-x

Cited by 26 publications

(5 citation statements)

References 6 publications

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“…Nasal disinfection was shown by Gould & Cruickshank (1957) to be effective in preventing staphylococcal skin lesions amongst nasal carriers outside hospital. Stratford, Rubbo, Christie & Dixson (1960) recommended the use of a framycetin nasal spray for the treatment and prevention of nasal carriage in hospital, and the present work confirms the value of this procedure. Its routine use in dermatological practice is justified by a reduction in the incidence of autogenous infections.…”

Section: Discussionsupporting

confidence: 77%

The mechanism and prevention of cross-infection in dermatological wards

Selwyn

1965

J. Hyg.

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Much of the extensive work on hospital cross-infection has of necessity been opportunist associated with the occurrence of sporadic outbreaks of infection. Investigations concentrated on such outbreaks cannot give a true picture of the general problem, and the value of any counter-measures which may have been introduced is not easily assessed.A pilot study, carried out in a large dermatology department, revealed an ideal model for the planned, long-term investigation of hospital infection (Selwyn, 1963). An endemic situation was uncovered in which the extensive skin lesions of in-patients were readily colonized by the abundant pathogenic bacteria present in the environment. Many of the infected patients became in their turn prolific dispersers of pathogens. A detailed study of these processes was facilitated by the long periods of hospital treatment which many patients with skin diseases require. Further work was therefore carried out in this neglected field to investigate the dynamic relationship which exists between the bacterial flora of these patients and that of their environment. The effect of simple anti-bacterial measures upon this relationship was also studied during two of the four stages of the investigation. The principal aim here was to assess the relative importance of nasal carriers and patients with infected lesions in the aetiology of hospital infection. MATERIALS AND METHODS Sampling proceduresThe investigation was carried out over a 2-year period in three dermatological wards. These are housed in a relatively modern pavilion, within a large teaching hospital. The two main wards, situated on different floors, are 68 ft. long, 28 ft. wide and 12 ft. high; each contains sixteen beds. The third ward, containing eight beds, is 32 ft. long; the width and height are as in the main wards.The degree of bacterial contamination was measured on two days of the week at representative sites in each ward, and in the adjacent day-room and bathroom. Air counts were performed with pairs of 3-5 in. Petri dishes containing blood agar and 7 5 % salt-milk agar respectively. These were exposed for 2 hr. periods as 'settle plates' and during each period similar plates were exposed in a 'Casella' slit sampler (but this could not be operated in the bathrooms). Solid surfaces were examined by contact-transfer using self-adhesive cellulose tape in a similar manner to that used by Thomas (1961) for swabbing skin. Direct impressions

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Section: Discussionsupporting

confidence: 77%

The mechanism and prevention of cross-infection in dermatological wards

Selwyn

1965

J. Hyg.

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“…These results are in marked contrast to those reported by Stratford et al (1960), who showed 100% success in the treatment of nasal carriers with framycetin. Their assessment of the carrier state in the framycetin-treated group of patients by deep nasal swabbing does not take into account, however, the possibility of vestibular carriage in these patients.…”

Section: A Comparison Of the Data Included Incontrasting

confidence: 99%

“…These attempts, however, have been only partially successful in the elimination of nasal carriage and in the prevention of infection (Henderson and Williams, 1961). The report from Australia of Stratford et al (1960) that framycetin sulphate (" soframycin ") spray (containing framycetin 1.25% and gramicidin 0.005%) rapidly and completely cleared staphylococci from the nose suggested that an effective method of treating nasal carriage was available. Some of the findings in this report, however, differ from those of other workers.…”

mentioning

confidence: 99%

“…Some of the findings in this report, however, differ from those of other workers. Stratford et al (1960) used deep nasal swabs to detect the presence of the carrier state and to assess the results of treatment with topical antibiotics. This technique was employed because a survey of 103 patients had indicated that deep swabbing was 17% more effective than superficial swabbing in the detection of nasal carriers.…”

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confidence: 99%

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Effect of Topical Framycetin on Staphylococcal Nasal Carriage

Porter¹,

McNeill²,

Miller³

et al. 1963

BMJ

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“…Isolation of the infected patient and treatment of the nasal carrier would therefore seem to be the prime steps in the control of such endemic staphylococcal infection. Recent reports indicate the facility with which control of nasal carriage may be achieved by such topical antibiotics as framycetin sulphate (" soframycin ") (Stratford et al, 1960).…”

Section: Summary Ad Condusionsmentioning

confidence: 99%

Long-term Results of Split-skin Grafting in Finger-tip Injuries

Moynihan¹

1961

BMJ

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Treatment of the Nasal Carrier of Staphylococcus Aureus With Framycetin and Other Antibacterials

Cited by 26 publications

References 6 publications

The mechanism and prevention of cross-infection in dermatological wards

The mechanism and prevention of cross-infection in dermatological wards

Effect of Topical Framycetin on Staphylococcal Nasal Carriage

Long-term Results of Split-skin Grafting in Finger-tip Injuries

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