Treatment of the neutropenia of Felty syndrome

Rheumatoid arthritis: A review of the cutaneous manifestations

“…63,178 This association has been attributed to the neutropenia, splenic dysfunction, relatively aggressive rheumatoid disease, and increased susceptibility to Epstein-Barr viral infection seen in patients with Felty syndrome. 63,178,179 Felty patients have more familial RA genetic linkage than RA control subjects, 176 with a significant HLA-DR4 contribution (96.4% versus 36.2% in RA controls), specifically of the DQw3 variant, 3b. 176 Lab studies show high RF titers and circulating immune complexes, 66,145 as well as antinuclear antibody positivity in 80% of patients.…”

Esplenomegalia gigante por síndrome de Felty

“…Por tratarse de un síndrome raro, se torna difícil realizar estudios clínicos controlados y randomizados sobre su manejo clínico. Entre las opciones terapéuticas se destacan el metotrexate, el factor estimulador de colonias de granulocitos, además de la [12][13][14] esplenectomía.…”

“…Rashba et al relataron que es una buena opción y que tiene una incidencia baja de efectos colaterales. El número total de neutrófilos aumenta en la misma proporción que ocurre disminución de las 12 infecciones.…”

Outcomes of splenectomy in T-cell large granular lymphocyte leukemia with splenomegaly and cytopenia

“…Among 118 cases reported of FS treated by surgical splenectomy, immediate hematological resolution of neutropenia was reported in 100% of the patients. However, the response was not persistent, with 20% of patients relapsing within first 6 months [23]. Clinically, splenectomy is beneficial in relieving the gastrointestinal related symptoms of fullness, nausea, early satiety and pain related to splenomegaly.…”