Treatment of thin endometrium with autologous platelet-rich plasma: a pilot study

Abstract

Endometrium is one of the main factors in pregnancy. During assisted reproductive technology (ART) treatments, some cycles are cancelled due to inadequate endometrial growth. This study was conducted to evaluate the effectiveness of platelet-rich plasma (PRP) in the treatment of thin endometrium. Ten patients with history of inadequate endometrial growth in frozen-thawed embryo transfer (FET) cycles were recruited into the study. Intrauterine infusion of PRP was performed. Endometrial thickness was assessed. Chemical and clinical pregnancies were reported. In all patients, endometrial thickness increased after PRP and embryo transfer was done in all of them. Five patients were pregnant. According to this study, it seems that PRP was effective for endometrial growth in patient with thin endometrium.

A Case Series on Platelet-Rich Plasma Revolutionary Management of Poor Responder Patients

“…Regarding the reproduction system, there have been reports stating its treating potential, especially intrauter- ine PRP treatment has been shown to promote the endometrial growth in patients with thin endometrium, improving the assisted reproduction outcome [25,[41][42][43]. In humans, PRP has been employed in an autologous ovarian transplantation in order to improve the vascularization and quality of the implant.…”

Platelet-rich plasma therapy and reproductive medicine

“…A similar report was recently published on the use of PRP to improve endometrial thickness in a series of 10 patients with history of frozen-thawed embryo transfer (FET) cancelations due to poor endometrial growth [15]. All 10 patients presented an endometrial thickness above 7 mm after PRP administration and five became pregnant after FET.…”

“…The authors concluded that PRP was effective in inducing endometrial development in patients with thin, poor endometrium. Despite the encouraging results, it is difficult to draw a single conclusion from these two reports, as one study showed the comparison of endometrial growth between different cycles (cycles without PRP and cycle with PRP administration [13]) and the second study showed the effect in the same cycle, as PRP was gradually administered [15]. In both situations, endometrial thickness improved for all patients to or above 7 mm.…”

“…In both situations, endometrial thickness improved for all patients to or above 7 mm. However, some patients received one [13] or two PRP infusions [13,15], and progesterone support was started when, endometrium reached the adequate thickness for embryo transfer [15]. Thus, it is not clear how the intrauterine administration of PRP may act to affect endometrial thickness.…”

Cellular therapies for the endometrium: An update

“…Moreover, eSC eVs increase blastomere count and VEGF release in co‐culture with murine embryos . One approach to this has been the use of platelet‐rich plasma in clinical trials for intrauterine infusion . These trials reported increased endometrial thickness and enhanced implantation and pregnancy rates with platelet‐rich plasma treatment.…”