Treatment of uncomplicated meconium ileus by gastrografin enema: A preliminary report

Noblett, Helen R.

doi:10.1016/0022-3468(69)90390-x

Cited by 183 publications

(63 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The gastrographin enema was initially described as the primary treatment for meconium ileus in 1969 by Nobretts [7]. It was believed that its hyperosmolarity would draw fluid into the bowel, causing stimulation of peristalsis, reducing viscosity and washing out the meconium.…”

Section: Introductionmentioning

confidence: 99%

Iopamidol enema treatment for meconium obstruction of prematurity in extremely low-birth weight infants: a safe and effective method

et al. 2009

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Iopamidol enema treatment for meconium obstruction of prematurity in extremely low-birth weight infants: a safe and effective method

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Several complications have been reported following Gastrografin enema like perforation, necrotizing enterocolitis, shock and occasional death [4]. Therefore, Noblett set some criteria to be fulfilled before performing this procedure [3]. Copeland et al also reported diminishing role of the contrast enema [4].…”

Section: Introductionmentioning

confidence: 99%

“…Uncomplicated meconium ileus can be treated with therapeutic contrast enemas as described by Noblett [3]. Several complications have been reported following Gastrografin enema like perforation, necrotizing enterocolitis, shock and occasional death [4].…”

Section: Introductionmentioning

confidence: 99%

Comparison of T Tube Ileostomy and Bishop Koop Ileostomy for the Management of Uncomplicated Meconium Ileus

et al. 2017

View full text Add to dashboard Cite

Background: Meconium ileus is a common cause of neonatal intestinal obstruction. Various surgical procedures are in practice for uncomplicated meconium ileus. Bishop Koop ileostomy allows distal passage of gut content and uses the distal absorptive area. T tube ileostomy avoids the need for gut resection and formal closure of stoma. The aim of this prospective interventional study was to compare the outcome of T-tube ileostomy and Bishop Koop ileostomy for the treatment of uncomplicated meconium ileus.

show abstract

“…However, it is important to note that this study was not powered to detect such important adverse effects of the intervention. The role of contrast agents such as barium enema is currently limited to evacuation of the meconium plug in neonates [38,39,40,41]. Cuenca et al [38] have reported a spontaneous resolution of 97% of cases of meconium plug with rectal stimulation or contrast barium enema treatment.…”

Section: Discussionmentioning

confidence: 99%

Meconium Evacuation for Facilitating Feed Tolerance in Preterm Neonates: A Systematic Review and Meta-Analysis

2016

View full text Add to dashboard Cite

Background: A delayed passage of meconium is considered as a risk factor for feed intolerance in preterm neonates. Objectives: The aim of this study was to review the effects of different therapeutic agents for meconium evacuation on feed tolerance in preterm neonates. Methods: A systematic review of randomised controlled trials (RCTs) of different therapeutic agents for meconium evacuation in preterm neonates (gestation <32 weeks and/or birth weight <1,500 g) using the Cochrane systematic review methodology was undertaken. Databases including Google Scholar were searched in January 2016. The primary outcome was the time to reach full feeds (TFF; ≥120 ml/kg feeds with stoppage of parenteral nutrition >24 h). Secondary outcomes included necrotising enterocolitis (NEC), weight at discharge and adverse effects. The results were summarised as per the GRADE guidelines. Results: Six RCTs (2 each of glycerine suppository and enema, 1 normal saline enema and 1 oral osmotic contrast agent; n = 442) with a low or unclear risk of bias were included. The pooled estimate (random effects model) showed no reduction in TFF [mean difference (MD) -0.03, 95% CI -2.47, 2.41, p = 0.98; level of evidence: low]. No differences in NEC [risk ratio (RR) 1.71, 95% CI 0.63, 4.65, p = 0.30; level of evidence: low] and weight at discharge (MD -0.08, 95% CI -0.30, 0.15, p = 0.50; level of evidence: low) were found. The trial assessing oral osmotic contrast agents reported a trend towards a higher incidence of NEC ≥ stage II. There were no other adverse effects. Conclusion: Limited low-quality evidence indicates that prophylactic glycerine suppository, small volume glycerine/normal saline enema or oral osmotic contrast agents to evacuate meconium did not reduce TFF in preterm neonates. Large, well-designed trials are essential to study this clinically significant issue.

show abstract

Treatment of uncomplicated meconium ileus by gastrografin enema: A preliminary report

Cited by 183 publications

References 7 publications

Iopamidol enema treatment for meconium obstruction of prematurity in extremely low-birth weight infants: a safe and effective method

Iopamidol enema treatment for meconium obstruction of prematurity in extremely low-birth weight infants: a safe and effective method

Comparison of T Tube Ileostomy and Bishop Koop Ileostomy for the Management of Uncomplicated Meconium Ileus

Meconium Evacuation for Facilitating Feed Tolerance in Preterm Neonates: A Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About