Treatment of vaginitis caused by Candida glabrata: use of topical boric acid and flucytosine

Sobel, Jack D.; Chaim, Walter; Nagappan, Viji; Leaman, Deborah

doi:10.1067/s0002-9378(03)00726-9

Cited by 171 publications

(98 citation statements)

References 13 publications

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“…Resistance with respect to the species showed C. albicans to have a high resistance of 84.62% to fluconazole. Previous work by some authors reported a resistance range of 17.7% -27% [4]. However no resistance to fluconazole was reported in a study done in US, among women with vaginal candidiasis [10].…”

Section: Discussionmentioning

confidence: 99%

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Isolation and antifungal sensitivity to Candida isolates in young females

Adesiji¹,

Ndukwe

Okanlawon

2011

Open Medicine

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AbstractA survey of 104 sexually active young females tested on on cervico-vaginal swabs showed that 26 of the females (25%) had vulvovaginal candidiasis with a species distribution of Candida isolates accounting for 13 (50%) with C. albicans, 6 (23%) with C. glabrata, 1 (4%) with C. krusei, and 6 (23%) with C. tropicalis. Of the 26 (25 %) subjects that were positive for VVC, 8 (7.8 %) were symptomatic and 18 (18.8 %) were asymptomatic. However, distribution among different age groups revealed an increase in the 23–27 age group. The comparative analysis of sensitivity of the given fungi to the number of antimycotic preparations used revealed the following: in fluconazole, 2 (7.8%) isolates were sensitive, 5 (19.2%) were susceptible and dose dependent, and 19 (73%) were resistant. For voriconazole, 4 (18.4%) isolates were sensitive, 6 (23.1%) were susceptible and dose dependent, and 16 (61.5%) were resistant. For nystatin, 5 (19.2%) isolates were sensitive, 10 (38.5%) were susceptible and dose dependent, and 11 (42.3%) were resistant. It appears that Candida isolates have a variable resistance response, but 19 (73%) had maximum resistance of the isolated fungi of the genus Candida to fluconazole. Therefore, further studies on the evaluation of combination therapy should be considered for a better outcome in treatment of vulvovaginal candidiasis.

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Section: Discussionmentioning

confidence: 99%

“…Vaginal candidiasis has been treated with topical azole antifungal medications in single or short term doses [3]. It has been well documented that most candida isolates demonstrate both intrinsically low susceptibility to the azoles, as well as the ability to develop resistance [4].…”

Section: Introductionmentioning

confidence: 99%

Isolation and antifungal sensitivity to Candida isolates in young females

Adesiji¹,

Ndukwe

Okanlawon

2011

Open Medicine

View full text Add to dashboard Cite

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“…It may also lead to colonisation with less susceptible Candida spp or development of resistance among usually susceptible Candida albicans strains and ultimately to refractory candidiasis [11,145]. The fact that there is no cure even after such a prolonged treatment course, with 60-70% having a recurrent episode within two months [94,116], may lead to frustration among the patients who may not accept and/or use antifungals for the next episode. Martinez [146] reported that the frequent and/or long-term antifungal therapy may predispose to bacterial vaginosis [146], and Patel et al [52] observed that young women with bacterial vaginosis may have an increased risk of genital candidiasis [52].…”

Section: Discussionmentioning

confidence: 99%

“…Have positive microscopy but fail to respond to the standard therapy i.e. with azole antifungals [94,110,111].…”

Section: Diagnosismentioning

confidence: 99%

“…The genetic polymorphic nature of the organisms is considered a major factor in its virulence [93]. The fungistatic mode of action of the azole compounds used to treat VVC and RVVC contributes to fungal recalcitrance to clearance [94], hence the vaginal relapses. There have been concerns that the repeated treatment might induce drug resistance, as well as shift the spectrum of the causative Candida spp increasing the chances of non-albicans spp [95,96,97].…”

Section: Microbial Factorsmentioning

confidence: 99%

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