Treatment of vaginitis caused by non-albicans Candida species

Sobel, Jack D.

doi:10.1080/14787210.2024.2347953

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Cited by 2 publications

References 76 publications

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Anti-biofilm activity of carvacrol-thymoquinone nanocarriers on vulvovaginal candidiasis isolates

Hajiaghaalizadeh,

Sheikharabi,

Jazi

et al. 2025

Diagnostic Microbiology and Infectious Disease

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Anti-biofilm activity of carvacrol-thymoquinone nanocarriers on vulvovaginal candidiasis isolates

Hajiaghaalizadeh,

Sheikharabi,

Jazi

et al. 2025

Diagnostic Microbiology and Infectious Disease

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Vaginal Microbiome and Inflammation Among Chinese Women

Yichan,

Ina,

Huarui

et al. 2024

Preprint

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Human papillomavirus (HPV) infection, cervical intraepithelial neoplasia (CIN), pelvic organ prolapse (POP), cervical polyps (CP), abnormal uterine bleeding (AUB), and vaginitis are common conditions encountered in gynecological practice. In this study, we collected vaginal secretions from patients diagnosed with these diseases (n = 310) and from healthy donors (n = 112) to analyze their vaginal microbiome using 16S rRNA sequencing and cytokine expression using a cytometric bead array (CBA). Our findings revealed that the vaginal microbiome in POP patients exhibited higher complexity compared to other groups. Regarding cytokine expression, levels of IL-1α, IL-1β, IL-6, IL-8, MCP-1, and MIG were significantly elevated in HPV and CIN patients. Analysis of microbial associations showed that Lactobacillus crispatus and Lactobacillus iners were significantly negatively correlated with IL-1α and IL-1β expression. In contrast, non-Lactobacillus bacteria, including Bifidobacterium breve, Prevotella bivia, Gardnerella vaginalis, Sneathia amnii, Sneathia sanguinegens, Prevotella amnii, Escherichia coli, and Chlamydia trachomatis, were positively correlated with IL-1α, IL-1β, IL-6, IL-8, MCP-1, and MIG levels. Furthermore, Lactobacillus iners exhibited a significant negative effect in the HPV and CIN patient groups.

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Treatment of vaginitis caused by non-albicans Candida species

Cited by 2 publications

References 76 publications

Anti-biofilm activity of carvacrol-thymoquinone nanocarriers on vulvovaginal candidiasis isolates

Anti-biofilm activity of carvacrol-thymoquinone nanocarriers on vulvovaginal candidiasis isolates

Vaginal Microbiome and Inflammation Among Chinese Women

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