Treatment of Venous Thrombosis With Anticoagulants Review of 1135 Cases

Marks, John W.; Truscott, Brian McN.; Withycombe, J. F. R.

doi:10.1016/s0140-6736(54)92504-0

Cited by 36 publications

(7 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hyaluronidase does not in our experience alter the local pain or bruising of subcutaneous heparin, with the exception that it diminishes the local irritant burning pain of strong heparin solution. Marks et al (1954) claim that bruising with intramuscular heparin therapy can be prevented by hyaluronidase, but the short period of administration (16 hours) may have been the preventive factor in their series. We have shown that just a small saline injection into a muscle, when the clotting-time is prolonged, can produce a large haematoma.…”

Section: Discussionmentioning

confidence: 99%

“…However, Bauer et al (1950) and Wynn and Goodwin (1952) noted that intramuscular haematomata occurred quite often with such treatment, and in the latter series forced cessation of therapy in 25% of cases. Marks et al (1954) gave intramuscular heparin mixed with hyaluronidase four-hourly for four doses, and state that the hyaluronidase overcomes the disadvantages of pain, local bruising, and variable absorption found with intramuscular heparin alone.…”

Section: House-physician University College Hospitalmentioning

confidence: 99%

See 1 more Smart Citation

Subcutaneous Heparin With and Without Hyaluronidase

Hollman¹,

Nagle²

1957

BMJ

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Section: House-physician University College Hospitalmentioning

confidence: 99%

Subcutaneous Heparin With and Without Hyaluronidase

Hollman¹,

Nagle²

1957

BMJ

View full text Add to dashboard Cite

“…It is likely that the concomitant spread of the use of heparin may have contributed to the popularity of early ambulation, thanks to its anti‐inflammatory/analgesic effect and the associated large decrease in mortality . Since then, bed rest has been shortened, being recommended only during heparin treatment (~ 10 days) or even only as long as the pain lasts . However, in the absence of clear evidence of its harmlessness, most physicians remained reluctant to recommend immediate mobilization, for fear of thrombus migration.…”

Section: The Modern Era: Ambulatory Management Of Dvt and The Developmentioning

confidence: 99%

The history and historical treatments of deep vein thrombosis

Galanaud

Laroche

Righini

2013

Journal of Thrombosis and Haemostasis

View full text Add to dashboard Cite

To cite this article: Galanaud J-P, Laroche J-P, Righini M. The history and historical treatments of deep vein thrombosis. J Thromb Haemost 2013; 11: 402-11.Summary. Deep vein thrombosis (DVT) is a common disease. However, unlike that of varicose veins, which have been depicted since antiquity in art and literature, its description was more recent in the history of medicine. The first well-documented case of DVT was reported during the Middle Ages: in 1271, Raoul developed a unilateral edema in the ankle, which then extended to the leg. The number of reported DVT cases steadily increased thereafter, particularly in pregnant and postpartum women. During the first half of the 20th century, well before the discovery of anticoagulants, many therapeutic approaches were used, and arose from the pathologic hypotheses that prevailed at their time. Despite the development of anticoagulants, and the fact that they were thought to dramatically decrease DVT mortality, numerous complementary treatments have also been developed during the last 50 years: they include vena cava clips and surgical thrombectomy, and are intended to decrease mortality or to prevent late complications. Most of these treatments have now been abandoned, or even forgotten. In this review, we recall also the discovery and the use of vitamin K antagonists and heparin, which have constituted the mainstay of treatment for decades. We also bring some perspective to historical aspects of this disease and its treatment, notably regarding elastic compression and early mobilization, but also abandoned and complementary treatments. In these times of change regarding DVT treatment, mainly marked by the arrival of new oral anticoagulants, efforts of physicians through the ages to treat this common disease provide a beautiful example of the history of knowledge.

show abstract

“…Tables 3 and 4 show pooled data on outcomes in historical series of untreated and treated patients with DVT and recognized PE. The overall risks of fatal PE in untreated recognized PE and treated recognized PE were 26.6 and 2.6%, respectively [43, 55–67]; corresponding figures for PDVT were 16.2 and 0.7% [58–60, 62, 65, 67–74]. The series reported by Hermann et al.…”

Section: Historical Series Of Patients With Treated and Untreated Vtementioning

confidence: 99%